Gene: CDO1

1036
CDO-I
cysteine dioxygenase type 1
protein-coding
5q22.3
Ensembl:ENSG00000129596 MIM:603943 Vega:OTTHUMG00000128891 UniprotKB:Q16878
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.393e-1 (AD)  3.554e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJA20.933
COPS80.933
PRNP0.925
ARL30.921
OAT0.918
CCDC28A0.917
OCIAD10.916
GHITM0.914
WASL0.914
ARL8B0.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.677
OR4F29-0.611
TFPI2-0.432
KLRB1-0.428
FOLR3-0.402
TBX21-0.401
KLRF1-0.398
C9orf153-0.394
FCRL3-0.394
KCNJ15-0.392

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDO1 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of CDO1 mRNA"25768209
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDO1 mRNA"28973690
C0312853-xylene3-xylene results in decreased expression of CDO1 mRNA12815608
C0804174-octylphenol4-octylphenol results in decreased expression of CDO1 mRNA16223563
D000082AcetaminophenAcetaminophen results in increased expression of CDO1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CDO1 mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of CDO1 mRNA19103213
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDO1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDO1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDO1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of CDO1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CDO1 protein26597043
D000638AmiodaroneAmiodarone affects the expression of CDO1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDO1 mRNA16483693
C015001arsenitearsenite results in increased methylation of CDO1 promoter23974009
C015001arsenitearsenite results in decreased expression of CDO1 mRNA18191166
C547126AZM551248AZM551248 results in decreased expression of CDO1 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of CDO1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDO1 mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDO1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDO1 mRNA21839799
C038328BEP protocolBEP protocol results in increased expression of CDO1 mRNA18987330
D004958EstradiolEstradiol results in decreased expression of CDO1 mRNA20106945
D004958EstradiolEstradiol affects the expression of CDO1 mRNA16684588
D004958EstradiolEstradiol results in decreased expression of CDO1 mRNA19484750
C095105bexarotenebexarotene results in decreased expression of CDO1 mRNA16648578
C095105bexarotenebexarotene analog results in increased expression of CDO1 mRNA28689802
C006780bisphenol Abisphenol A affects the expression of CDO1 mRNA25181051
C032036bromobenzenebromobenzene results in decreased expression of CDO1 mRNA12628495
C032036bromobenzenebromobenzene results in increased expression of CDO1 mRNA15056800
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDO1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDO1 mRNA18178546
D002737ChloropreneChloroprene results in increased expression of CDO1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of CDO1 mRNA18353800
D002994ClofibrateClofibrate affects the expression of CDO1 mRNA16081524
D002994ClofibrateClofibrate affects the expression of CDO1 mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of CDO1 mRNA17602206
D003300CopperCopper results in decreased expression of CDO1 mRNA22465980
D003345CorticosteroneCorticosterone results in increased expression of CDO1 mRNA15755911
C030123coumarincoumarin affects the expression of CDO1 mRNA16963487
D003471CuprizoneCuprizone results in decreased expression of CDO1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CDO1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of CDO1 mRNA23830897
D003545CysteineCDO1 protein results in increased oxidation of Cysteine23665415
D003545Cysteine[CDO1 protein results in increased oxidation of Cysteine] which results in increased chemical synthesis of cysteine sulfinic acid23665415
C013461cysteine sulfinic acidCDO1 protein results in increased chemical synthesis of cysteine sulfinic acid16611640
C013461cysteine sulfinic acid[CDO1 protein results in increased oxidation of Cysteine] which results in increased chemical synthesis of cysteine sulfinic acid23665415
D003907DexamethasoneDexamethasone results in increased expression of CDO1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA16054899
D003907Dexamethasone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D002945CisplatinCisplatin results in decreased expression of CDO1 mRNA18246545
C000944dicrotophosdicrotophos results in decreased expression of CDO1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of CDO1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CDO1 mRNA16223563
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CDO1 mRNA28943392
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of CDO1 mRNA16223563
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CDO1 mRNA17072980
D004237DiuronDiuron results in decreased expression of CDO1 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDO1 mRNA17108234
D005001EthionineEthionine affects the expression of CDO1 mRNA19483382
D005485FlutamideFlutamide results in decreased expression of CDO1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene20938992
C039281furanfuran results in decreased expression of CDO1 mRNA25539665
D005897GlafenineGlafenine results in decreased expression of CDO1 mRNA24136188
D005978GlutathioneCDO1 protein results in increased abundance of Glutathione23665415
C003949hypotaurineCDO1 protein results in increased abundance of hypotaurine23665415
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA28628672
D007501IronIron binds to and results in increased activity of CDO1 protein16611640
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA16054899
D0150561-Methyl-3-isobutylxanthine[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D007545IsoproterenolIsoproterenol results in increased expression of CDO1 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDO1 mRNA24796395
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDO1 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDO1 mRNA17475336|1806909
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CDO1 mRNA16809437
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDO1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of CDO1 mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of CDO1 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of CDO1 mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of CDO1 mRNA18417182
C484027oligofectamineoligofectamine results in increased expression of CDO1 mRNA14668052
D009853OmeprazoleOmeprazole affects the expression of CDO1 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CDO1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of CDO1 mRNA18042831
D010269ParaquatParaquat affects the expression of CDO1 mRNA16854511
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CDO1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDO1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CDO1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CDO1 mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CDO1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of CDO1 mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of CDO1 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDO1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDO1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of CDO1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CDO1 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid affects the expression of CDO1 mRNA19483382
D028321Plant PreparationsPlant Preparations results in increased expression of CDO1 mRNA26945725
D011192Potassium DichromatePotassium Dichromate results in increased expression of CDO1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CDO1 mRNA19162173
D011374ProgesteroneProgesterone affects the expression of CDO1 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of CDO1 mRNA20726854
D011441PropylthiouracilPropylthiouracil affects the expression of CDO1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of CDO1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CDO1 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of CDO1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA19059307
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA16054899
C089730rosiglitazone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CDO1 mRNA"16251409
C009277sodium arsenatesodium arsenate results in decreased expression of CDO1 mRNA23922661
D012969Sodium FluorideSodium Fluoride results in increased expression of CDO1 mRNA27257137
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDO1 mRNA26378955
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of CDO1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDO1 mRNA16443690|1849575
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of CDO1 mRNA16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDO1 mRNA15667827|1605489
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDO1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDO1 mRNA16054898|1846511
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CDO1 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of CDO1 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of CDO1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CDO1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CDO1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CDO1 mRNA18230668
D014212TretinoinTretinoin results in increased expression of CDO1 mRNA28689802
C012589trichostatin Atrichostatin A results in decreased expression of CDO1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of CDO1 mRNA15901671
D014415TunicamycinTunicamycin results in increased expression of CDO1 mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of CDO1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of CDO1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of CDO1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of CDO1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CDO1 mRNA15901671
C025643vinclozolinvinclozolin results in decreased expression of CDO1 mRNA20566332
C025643vinclozolinvinclozolin results in increased expression of CDO1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of CDO1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008198ferrous iron binding-IEA-  
GO:0017172cysteine dioxygenase activity-ISS-  
GO:0017172cysteine dioxygenase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000097sulfur amino acid biosynthetic process-TAS12110289  
GO:0006534cysteine metabolic process-TAS12110289  
GO:0006954inflammatory response-TAS12110289  
GO:0007595lactation-IEA-  
GO:0019448L-cysteine catabolic process-TAS-  
GO:0033762response to glucagon-IEA-  
GO:0042412taurine biosynthetic process-IEA-  
GO:0042412taurine biosynthetic process-TAS12871209  
GO:0043200response to amino acid-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0055114oxidation-reduction process-TAS12110289  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS12110289  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa00430Taurine and hypotaurine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1614558Degradation of cysteine and homocysteineTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22011669Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (2012 Jan)Kwon YJJ Thorac Oncol