Gene: HMG20A

10363
HMGX1|HMGXB1
high mobility group 20A
protein-coding
15q24.3
Ensembl:ENSG00000140382 MIM:605534 Vega:OTTHUMG00000143729 UniprotKB:Q9NP66
NC_000015.10
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.335e-1 (AD)  6.865e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD13C0.942
CDC270.941
RTF10.94
ATAD10.938
ARL10.938
IMPAD10.936
NUDT210.935
PWP10.934
ACTR20.933
EXOC10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.651
OR4F29-0.608
MTRNR2L6-0.319
WDR38-0.318
CCDC102A-0.306
MTRNR2L9-0.306
EVC2-0.3
C7orf61-0.294
FOXJ1-0.291
CSAG1-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of HMG20A mRNA21420995
D001280AtrazineAtrazine results in increased expression of HMG20A mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of HMG20A mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HMG20A mRNA22228805
C006780bisphenol Abisphenol A affects the methylation of HMG20A promoter27334623
C006780bisphenol Abisphenol A affects the expression of HMG20A mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of HMG20A mRNA20106945
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HMG20A mRNA17555576
D005839GentamicinsGentamicins results in increased expression of HMG20A mRNA22061828
C016517indole-3-carbinolindole-3-carbinol affects the expression of HMG20A mRNA21396975
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HMG20A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HMG20A mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HMG20A mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HMG20A mRNA18593933
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HMG20A mRNA19710929
D013629TamoxifenTamoxifen affects the expression of HMG20A mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMG20A mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HMG20A mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of HMG20A gene27618143
D014635Valproic AcidValproic Acid affects the expression of HMG20A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HMG20A mRNA19101580|2317975
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HMG20A mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-NAS10773667  
GO:0003700DNA-binding transcription factor activity-NAS10773667  
GO:0005515protein binding-IPI16189514  21258344  23275563  25416956  26496610  26871637  
27107014  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006325chromatin organization-NAS10773667  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS10773667  
GO:0033234negative regulation of protein sumoylation-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS10773667  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal