Gene info: ID 10365

Gene: KLF2

GENE ID: 10365

Synonyms: LKLF

Description: Kruppel like factor 2

Gene type: protein-coding

Location: 19p13.11

dbXrefs: Ensembl:ENSG00000127528 MIM:602016 Vega:OTTHUMG00000182330 UniprotKB:Q9Y5W3

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.616e-1 (AD) 3.414e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg18473733	chr19:16437362	KLF2		1.840e-11	Maternal smoking in pregnancy	27040690
cg18473733	chr19:16437362	KLF2		5.180e-15	Maternal smoking in pregnancy	27040690
cg18473733	chr19:16437362	KLF2		2.040e-12	Maternal smoking in pregnancy	27040690
cg05906166	chr19:16437057	KLF2		2.500e-17	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KLF4	0.756
DUSP1	0.681
SOX18	0.662
RAMP2	0.651
TMEM88	0.644
LSR	0.627
CLEC14A	0.619
HSPA12B	0.618
ID1	0.615
FOXS1	0.611

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FSTL5	-0.277
OR4F29	-0.264
GRIP1	-0.248
MACROD2	-0.248
GPR52	-0.248
BEND4	-0.246
HSPA4L	-0.246
RAB27B	-0.246
HOOK1	-0.245
TENM3	-0.245

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of KLF2 mRNA	19933214
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of KLF2 mRNA	22193206
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of KLF2 mRNA"	18648102
C034343	4-aminobenzhydrazide	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of KLF2 mRNA]	24530881
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of KLF2 mRNA"	19815564
D000082	Acetaminophen	Acetaminophen results in increased expression of KLF2 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of KLF2 mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KLF2 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of KLF2 mRNA	26705709
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of KLF2 mRNA	15894712
C015001	arsenite	arsenite results in decreased expression of KLF2 mRNA	15894712
C006680	baicalein	baicalein results in increased expression of KLF2 mRNA	24560969
D001554	Benzene	Benzene results in decreased expression of KLF2 mRNA	19162166
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of KLF2 mRNA	26377693
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of KLF2 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KLF2 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KLF2 mRNA	20713471\|2156981
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLF2 mRNA"	20382639
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in increased expression of KLF2 mRNA	18192240
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in increased expression of KLF2 protein	18192240
C006780	bisphenol A	bisphenol A results in increased expression of KLF2 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of KLF2 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KLF2 mRNA	28628672
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of KLF2 mRNA	24356939
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of KLF2 mRNA	20847119
D020122	tert-Butylhydroperoxide	pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KLF2 mRNA]	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of KLF2 mRNA	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of KLF2 mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KLF2 mRNA]	20847119
D002104	Cadmium	Cadmium results in decreased expression of KLF2 mRNA	24084258
D002220	Carbamazepine	Carbamazepine affects the expression of KLF2 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of KLF2 mRNA	17484886
D002922	Ciguatoxins	Ciguatoxins affects the expression of KLF2 mRNA	18353800
D002994	Clofibrate	Clofibrate results in decreased expression of KLF2 mRNA	17585979
D019327	Copper Sulfate	Copper Sulfate results in increased expression of KLF2 mRNA	19549813
D003314	Corn Oil	Corn Oil affects the expression of KLF2 mRNA	16360708
C030123	coumarin	coumarin results in decreased expression of KLF2 mRNA	18480146
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of KLF2 mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF2 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF2 mRNA	19770486
C017160	cypermethrin	cypermethrin results in decreased expression of KLF2 mRNA	25424538
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of KLF2 mRNA	23914054
C014347	decitabine	decitabine affects the expression of KLF2 mRNA	23300844
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KLF2 mRNA	28628672
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA	25559859
D003907	Dexamethasone	Dexamethasone results in increased expression of KLF2 mRNA	21041162\|2273378
D003907	Dexamethasone	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA]	25559859
D002945	Cisplatin	Cisplatin affects the expression of KLF2 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of KLF2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of KLF2 mRNA	27392435
D002945	Cisplatin	KLF2 protein affects the susceptibility to Cisplatin	16217747
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of KLF2 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of KLF2 mRNA	18042831
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of KLF2 mRNA	21041162
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of KLF2 mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of KLF2 mRNA	22193206
D004237	Diuron	Diuron results in decreased expression of KLF2 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in increased expression of KLF2 mRNA	18510171
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of KLF2 mRNA	17108234
C018063	ethyl protocatechuate	ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of KLF2 protein]	24338020
C000499	ferric oxide	ferric oxide analog results in decreased expression of KLF2 mRNA	25086211
D005557	Formaldehyde	Formaldehyde results in increased expression of KLF2 mRNA	23416264
C096856	FTI 277	FTI 277 results in increased expression of KLF2 mRNA	18192240
C096856	FTI 277	FTI 277 results in increased expression of KLF2 protein	18192240
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of KLF2 mRNA]	22687549
C102521	GGTI 298	GGTI 298 results in increased expression of KLF2 mRNA	18192240
C102521	GGTI 298	GGTI 298 results in increased expression of KLF2 protein	18192240
C004312	glycidol	glycidol results in decreased expression of KLF2 mRNA	24915197
D017313	Fenretinide	Fenretinide results in increased expression of KLF2 mRNA	28973697
C013038	hydroxyhydroquinone	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of KLF2 mRNA]	24530881
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of KLF2 mRNA	24530881
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KLF2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of KLF2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA	25559859
D015056	1-Methyl-3-isobutylxanthine	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA]	25559859
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of KLF2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of KLF2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of KLF2 mRNA	23086925\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of KLF2 mRNA	24435446\|2675264
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of KLF2 mRNA]	22687549
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of KLF2 mRNA	22687549
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA	22563483
D008628	Mercury	Mercury results in decreased expression of KLF2 mRNA	19937285
D008727	Methotrexate	Methotrexate results in decreased expression of KLF2 mRNA	17400583
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of KLF2 mRNA	20713471
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KLF2 mRNA"	20188158
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA]	20493886
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of KLF2 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of KLF2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of KLF2 mRNA"	25554681\|2562005
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of KLF2 mRNA	19812364
C010463	n-hexanal	n-hexanal affects the expression of KLF2 mRNA	26880647
C028007	nickel monoxide	nickel monoxide results in decreased expression of KLF2 mRNA	19167457
C007350	nitrofen	nitrofen results in decreased expression of KLF2 mRNA	21053160
C025589	ochratoxin A	ochratoxin A results in decreased expression of KLF2 mRNA	24356939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of KLF2 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of KLF2 mRNA	18042831
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA	22563483
D010269	Paraquat	Paraquat results in decreased expression of KLF2 mRNA	22563483
D010269	Paraquat	Paraquat results in decreased expression of KLF2 mRNA	26813466
D010269	Paraquat	Paraquat results in decreased expression of KLF2 protein	26813466
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of KLF2 mRNA	18593933
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of KLF2 mRNA	23602845
D010672	Phenytoin	Phenytoin results in increased expression of KLF2 mRNA	20345932
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of KLF2 mRNA	20847119
C060836	pioglitazone	pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KLF2 mRNA]	20847119
C006253	pirinixic acid	pirinixic acid results in increased expression of KLF2 mRNA	18445702
D010938	Plant Oils	Plant Oils results in increased expression of KLF2 mRNA	23370395
C005556	propionaldehyde	propionaldehyde results in decreased expression of KLF2 mRNA	26079696
C107773	pterostilbene	MAPK7 protein affects the reaction [pterostilbene results in increased expression of KLF2 mRNA]	26443543
C107773	pterostilbene	pterostilbene promotes the reaction [KLF2 protein binds to SOD2 promoter]	26443543
C107773	pterostilbene	pterostilbene results in increased expression of KLF2 mRNA	26443543
C107773	pterostilbene	pterostilbene results in increased expression of KLF2 protein	26443543
C428725	pyridaben	pyridaben results in decreased expression of KLF2 mRNA	22563483
C059514	resveratrol	KLF2 protein promotes the reaction [resveratrol results in increased expression of NOS3 mRNA]	19815564
C059514	resveratrol	KLF2 protein promotes the reaction [resveratrol results in increased expression of NPPC mRNA]	19815564
C059514	resveratrol	KLF2 protein promotes the reaction [resveratrol results in increased expression of THBD mRNA]	19815564
C059514	resveratrol	MAP2K5 protein promotes the reaction [resveratrol results in increased expression of KLF2 mRNA]	19815564
C059514	resveratrol	resveratrol promotes the reaction [KLF2 protein binds to SOD2 promoter]	26443543
C059514	resveratrol	resveratrol results in increased expression of KLF2 mRNA	19815564\|2644354
C059514	resveratrol	resveratrol results in increased expression of KLF2 protein	26443543
C059514	resveratrol	SIRT1 protein promotes the reaction [resveratrol results in increased expression of KLF2 mRNA]	19815564
C059514	resveratrol	sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA]	19815564
C059514	resveratrol	resveratrol results in increased expression of KLF2 mRNA	25338179
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of KLF2 mRNA	21127053
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of KLF2 mRNA	20847119
C089730	rosiglitazone	ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of KLF2 protein]	24338020
D012402	Rotenone	Rotenone results in decreased expression of KLF2 mRNA	27979718
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of KLF2 mRNA	17540011
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of KLF2 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of KLF2 mRNA	19073995
C440975	silybin	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of KLF2 mRNA]	25559859
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA]	20493886
D019821	Simvastatin	Simvastatin results in increased expression of KLF2 mRNA	17428261\|2049388
D019821	Simvastatin	Simvastatin results in decreased expression of KLF2 mRNA	22305382
D020123	Sirolimus	Sirolimus results in increased expression of KLF2 mRNA	24356939
C439060	sirtinol	sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA]	19815564
C009277	sodium arsenate	sodium arsenate results in decreased expression of KLF2 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of KLF2 mRNA	20371982
C017947	sodium arsenite	sodium arsenite results in decreased expression of KLF2 mRNA	16014739\|2527062
D053260	Soot	Soot affects the expression of KLF2 mRNA	26551751
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of KLF2 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of KLF2 mRNA]	17337447
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KLF2 mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KLF2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KLF2 mRNA	20159946
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF2 mRNA	17337447\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KLF2 mRNA	23238561
C020809	tetrathiomolybdate	tetrathiomolybdate analog results in decreased expression of KLF2 mRNA	19323979
D013792	Thalidomide	Thalidomide results in decreased expression of KLF2 mRNA	28892372
C009495	titanium dioxide	titanium dioxide results in decreased expression of KLF2 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of KLF2 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of KLF2 mRNA	23228038
C032910	triadimefon	triadimefon results in decreased expression of KLF2 mRNA	26705709
C011559	tributyltin	tributyltin results in increased expression of KLF2 mRNA	24356939
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of KLF2 mRNA	20186580
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of KLF2 gene	27618143
C012589	trichostatin A	trichostatin A affects the expression of KLF2 mRNA	28542535
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KLF2 mRNA]	20847119
C057693	troglitazone	troglitazone results in decreased expression of KLF2 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased methylation of KLF2 gene	28853863
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF2 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of KLF2 gene	29154799
C025643	vinclozolin	vinclozolin affects the expression of KLF2 mRNA	19015723
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of KLF2 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IMP	22327366
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003677	DNA binding	-	IMP	22327366
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IDA	21063504
GO:0005515	protein binding	-	IPI	16617118 21382345
GO:0043565	sequence-specific DNA binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	26299712
GO:0000902	cell morphogenesis	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0032715	negative regulation of interleukin-6 production	-	IEA	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	-	IMP	23043106
GO:0040029	regulation of gene expression, epigenetic	-	IEA	-
GO:0043249	erythrocyte maturation	-	IEA	-
GO:0045429	positive regulation of nitric oxide biosynthetic process	-	IDA	21768538
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	21063504
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	20551324
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	22327366
GO:0051247	positive regulation of protein metabolic process	-	IGI	20551324
GO:0060509	type I pneumocyte differentiation	-	IEA	-
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0071347	cellular response to interleukin-1	-	IEA	-
GO:0071356	cellular response to tumor necrosis factor	-	IEA	-
GO:0071409	cellular response to cycloheximide	-	IEA	-
GO:0071498	cellular response to fluid shear stress	-	IMP	22327366
GO:0071499	cellular response to laminar fluid shear stress	-	IMP	23043106
GO:0097533	cellular stress response to acid chemical	-	IMP	26299712
GO:1901653	cellular response to peptide	-	IEA	-
GO:1903671	negative regulation of sprouting angiogenesis	-	IMP	26299712

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IMP	22327366
GO:0005634	nucleus	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22737924	[The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease]. (2012 Mar)	Liu XY	Zhongguo Ying Yong Sheng Li Xue Za Zhi
28088955	[Effect of Kruppel like zinc finger transcription factor 2 on gamma-glutamylcysteine synthetase in bronchial epithelial cells of chronic obstructive pulmonary disease]. (2017 Jan 10)	Li J	Zhonghua Yi Xue Za Zhi