Gene: CACNG3

10368
-
calcium voltage-gated channel auxiliary subunit gamma 3
protein-coding
16p12.1
Ensembl:ENSG00000006116 MIM:606403 Vega:OTTHUMG00000131651 UniprotKB:O60359
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.552e-1 (AD)  9.874e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NGEF0.974
PGBD50.967
SLC8A20.962
PRKCG0.956
CAMKK20.955
KCNB10.954
C1orf1150.953
KCTD10.953
RAB3A0.951
KIAA05130.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.583
WWTR1-0.579
MYL3-0.566
YES1-0.559
SNHG18-0.551
REST-0.549
HEY2-0.541
CNN2-0.539
RAI14-0.534
KIAA0040-0.527

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CACNG3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CACNG3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CACNG3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CACNG3 mRNA20458559
D001464BariumCACNG3 protein affects the transport of Barium11313431
C006780bisphenol Abisphenol A affects the expression of CACNG3 mRNA25181051
D002211CapsaicinCapsaicin results in decreased expression of CACNG3 mRNA16278290
D002509CephaloridineCephaloridine results in increased expression of CACNG3 mRNA18500788
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CACNG3 mRNA21266533
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of CACNG3 mRNA"27840820
D005419FlavonoidsFlavonoids results in decreased expression of CACNG3 mRNA18035473
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CACNG3 mRNA"20188158
C410127PCB 180PCB 180 results in decreased expression of CACNG3 mRNA23829299
C025462sulindac sulfidesulindac sulfide results in increased expression of CACNG3 mRNA16184548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CACNG3 mRNA24680724
D014635Valproic AcidValproic Acid results in decreased expression of CACNG3 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CACNG3 gene25560391
C025643vinclozolinvinclozolin affects the expression of CACNG3 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005245voltage-gated calcium channel activity-IBA21873635  
GO:0005245voltage-gated calcium channel activity-NAS10221464  
GO:0016247channel regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-ISS-  
GO:0006816calcium ion transport-NAS10221464  
GO:0008104protein localization-ISS-  
GO:0019226transmission of nerve impulse-IBA21873635  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosome-IBA21873635  
GO:0098970postsynaptic neurotransmitter receptor diffusion trapping-IBA21873635  
GO:0099590neurotransmitter receptor internalization-IBA21873635  
GO:2000311regulation of AMPA receptor activity-IBA21873635  
GO:2000311regulation of AMPA receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005891voltage-gated calcium channel complex-NAS10221464  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0032281AMPA glutamate receptor complex-IBA21873635  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0036477somatodendritic compartment-ISS-  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-397014Muscle contractionTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS
R-HSA-5576893Phase 2 - plateau phaseTAS
R-HSA-5682910LGI-ADAM interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21169531Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)Spencer KLInvest Ophthalmol Vis Sci