Gene info: ID 10381

Gene: TUBB3

GENE ID: 10381

Description: tubulin beta 3 class III

Gene type: protein-coding

Location: 16q24.3

dbXrefs: Ensembl:ENSG00000258947 MIM:602661 Vega:OTTHUMG00000138985 UniprotKB:Q13509

RefSeq: NG_027810.1

Retrived from: PubMed

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.474e-1 (AD) 7.277e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs3212369	chr16:89920352 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TUBG1	0.95
TUBB2A	0.935
FARSA	0.93
ATP6V0D1	0.929
TOMM40	0.921
TUBA4A	0.918
ATP13A2	0.914
CRMP1	0.913
OTUB1	0.91
TUBB	0.91

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.584
OR4F29	-0.52
REST	-0.46
ASB4	-0.434
RAI14	-0.43
YES1	-0.421
EBF1	-0.421
DISC1	-0.415
PARD3B	-0.411
IL18RAP	-0.402

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01873	Epothilone D	Small Molecule	189453-10-9	Experimental\|Investigational	Target
DB03010	Patupilone	Small Molecule	152044-54-7	Experimental\|Investigational	Target
DB04845	Ixabepilone	Small Molecule	219989-84-1	Approved\|Investigational	Target
DB05147	CYT997	Small Molecule	-	Investigational	Target
DB06042	ZEN-012	Small Molecule	-	Investigational	Target
DB12695	Phenethyl Isothiocyanate	Small Molecule	2257-09-2	Investigational	Target

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TUBB3 mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TUBB3 mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of TUBB3 mRNA"	15302862
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TUBB3 mRNA"	23146750
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA"	20865013
C440850	2,4,3',5'-tetramethoxystilbene	"2,4,3',5'-tetramethoxystilbene results in decreased expression of TUBB3 mRNA"	20490654
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TUBB3 mRNA"	23146750
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of TUBB3 mRNA"	20206263
C075773	4-phenylbutyric acid	[4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein	18497984
C075773	4-phenylbutyric acid	[4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein	18497984
C075773	4-phenylbutyric acid	4-phenylbutyric acid affects the expression of TUBB3 protein	18497984
C075773	4-phenylbutyric acid	[decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein	18497984
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of TUBB3 protein"	28073004
C048324	abamectin	abamectin results in decreased expression of TUBB3 protein	19879343
D000082	Acetaminophen	Acetaminophen affects the expression of TUBB3 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA]	28153600
D020106	Acrylamide	Acrylamide results in decreased expression of TUBB3 protein	18599177
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of TUBB3 protein	26072098
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TUBB3 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of TUBB3 protein	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of TUBB3 mRNA	12558987
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of TUBB3 protein	15255259
C406592	azaspiracid	azaspiracid results in increased expression of TUBB3 mRNA	21853993
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TUBB3 mRNA	20106945\|2231617
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TUBB3 mRNA"	20382639
D004958	Estradiol	Estradiol results in increased expression of TUBB3 mRNA	19466750\|2727128
D004958	Estradiol	Estradiol results in increased expression of TUBB3 protein	19466750\|2727128
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]	19466750
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]	19466750
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TUBB3 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of TUBB3 mRNA	27271280
C006780	bisphenol A	bisphenol A results in decreased expression of TUBB3 protein	27271280
C006780	bisphenol A	IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]	27271280
C006780	bisphenol A	IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 protein]	27271280
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB3 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of TUBB3 mRNA	24586524
C006780	bisphenol A	bisphenol A results in decreased methylation of TUBB3 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of TUBB3 mRNA	25381574\|2596372
C006780	bisphenol A	bisphenol A results in increased expression of TUBB3 mRNA	25181051
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]	25963729
C018475	butyraldehyde	butyraldehyde results in increased expression of TUBB3 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of TUBB3 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TUBB3 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TUBB3 protein	21796402
D002220	Carbamazepine	Carbamazepine affects the expression of TUBB3 mRNA	24752500
D002220	Carbamazepine	Carbamazepine results in decreased expression of TUBB3	25524013
D002235	Carbofuran	Carbofuran results in decreased expression of TUBB3 mRNA	28982980
D002509	Cephaloridine	Cephaloridine results in increased expression of TUBB3 mRNA	18500788
C473711	Chir 99021	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA"	20865013
C100187	chloropicrin	chloropicrin results in increased expression of TUBB3 mRNA	26352163\|2847649
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of TUBB3 protein	26018426
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TUBB3 mRNA	16772336
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TUBB3 protein	16772336
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TUBB3 protein	18375950
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of TUBB3 mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TUBB3 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]	25963729
D003474	Curcumin	Curcumin results in increased expression of TUBB3 mRNA	25963729
D016572	Cyclosporine	Cyclosporine results in decreased expression of TUBB3 mRNA	22147139\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of TUBB3 mRNA	20106945\|2163298
C037304	cyhalothrin	cyhalothrin promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA]	28385489
D003561	Cytarabine	Cytarabine results in decreased expression of TUBB3 protein	21198554
C017180	decamethrin	decamethrin inhibits the reaction [NGF protein results in increased expression of TUBB3 mRNA]	28385489
C014347	decitabine	decitabine affects the expression of TUBB3 mRNA	18497984
C014347	decitabine	decitabine affects the expression of TUBB3 protein	18497984
C014347	decitabine	[decitabine co-treated with 4-phenylbutyric acid] affects the expression of TUBB3 protein	18497984
D003676	Deferoxamine	Deferoxamine results in increased expression of TUBB3 mRNA	16772336
D003703	Demecolcine	Demecolcine results in decreased expression of TUBB3 mRNA	23649840
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TUBB3 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB3 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNA	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TUBB3 mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin results in increased expression of TUBB3 protein	22023808
D004008	Diclofenac	Diclofenac affects the expression of TUBB3 mRNA	24752500
D004041	Dietary Fats	Dietary Fats results in increased expression of TUBB3 mRNA	25016146
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TUBB3 mRNA	20920545
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TUBB3 protein	20920545
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TUBB3 mRNA	21527772
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of TUBB3 mRNA	22105179
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of TUBB3 mRNA	21853993\|2893901
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of TUBB3 mRNA	24690739
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of TUBB3 protein	19272428
C084101	doramectin	doramectin results in decreased expression of TUBB3 protein	19879343
C070609	EMD 53998	EMD 53998 analog results in decreased expression of TUBB3 mRNA	24977338
D004642	Emodin	Emodin results in decreased expression of TUBB3 mRNA	16045814
D000431	Ethanol	Ethanol results in decreased expression of TUBB3 mRNA	16770775
D000431	Ethanol	Ethanol results in decreased expression of TUBB3 protein	16770775
D000431	Ethanol	Ethanol results in increased expression of TUBB3 protein	19609968
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TUBB3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TUBB3 mRNA	17108234
D005472	Fluorouracil	Fluorouracil results in decreased expression of TUBB3 mRNA	19272435
D005473	Fluoxetine	Fluoxetine results in decreased expression of TUBB3 mRNA	20857517
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]	19466750
C056933	fumonisin B1	fumonisin B1 results in increased expression of TUBB3 mRNA	16221962
D005978	Glutathione	Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA]	28153600
D006533	Heptachlor	Heptachlor promotes the reaction [NGF protein results in increased expression of TUBB3 mRNA]	28385489
D017313	Fenretinide	Fenretinide results in increased expression of TUBB3 protein	17110918
C499403	icaritin	icaritin results in increased expression of TUBB3 protein	19135036
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TUBB3 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TUBB3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNA	16054899
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TUBB3 mRNA	23430699\|2683047
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TUBB3 protein	26830473
C410337	K 7174	K 7174 results in increased expression of TUBB3 mRNA	24086573
C006552	kaempferol	kaempferol results in decreased expression of TUBB3 protein	26683311
C029433	lead tetraacetate	lead tetraacetate results in decreased expression of TUBB3 mRNA	20865013
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TUBB3 mRNA	23203475
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TUBB3 mRNA	21385734
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TUBB3 protein	21385734
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of TUBB3 protein	26558463
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TUBB3 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TUBB3 promoter"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TUBB3 protein	26558463
D016686	Monocrotaline	Monocrotaline results in decreased expression of TUBB3 protein	21781985
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate affects the expression of TUBB3 mRNA"	19615344
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of TUBB3 mRNA]"	19615344
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TUBB3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TUBB3 mRNA"	25554681
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA]"	24929042
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of TUBB3 mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TUBB3 mRNA	27935865
D016877	Oxidants	Oxidants results in increased expression of TUBB3 protein	18375950
D052638	Particulate Matter	Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA]	28153600
D052638	Particulate Matter	Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA]	28153600
D052638	Particulate Matter	Particulate Matter results in decreased expression of TUBB3 mRNA	28153600
D052638	Particulate Matter	Particulate Matter results in increased expression of TUBB3 mRNA	24769257
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of TUBB3 mRNA	18593933
C073402	PD 123319	PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]	17068200
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TUBB3 protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TUBB3 protein	19954255
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of TUBB3 protein	26178269
C058305	phenethyl isothiocyanate	TUBB3 protein binds to phenethyl isothiocyanate	21838287
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of TUBB3 mRNA	27935865
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TUBB3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TUBB3 mRNA	15302862
D010938	Plant Oils	Plant Oils results in increased expression of TUBB3 mRNA	23370395
D011374	Progesterone	Progesterone results in decreased expression of TUBB3 mRNA	20726854
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TUBB3 mRNA	24780913
C009172	rhodioloside	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA]"	24929042
C009172	rhodioloside	NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 mRNA]	24929042
C009172	rhodioloside	NOG protein inhibits the reaction [rhodioloside results in increased expression of TUBB3 protein]	24929042
C009172	rhodioloside	rhodioloside results in increased expression of TUBB3 mRNA	24929042
C009172	rhodioloside	rhodioloside results in increased expression of TUBB3 protein	24929042
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBB3 mRNA	16054899
D012402	Rotenone	Rotenone affects the expression of TUBB3 mRNA	21893155
D012402	Rotenone	TRP53 affects the reaction [Rotenone affects the expression of TUBB3 mRNA]	21893155
C010327	salinomycin	salinomycin results in decreased expression of TUBB3 mRNA	19682730
D012524	Sarin	Sarin results in decreased expression of TUBB3 protein	25842371
D012524	Sarin	Sarin results in decreased expression of TUBB3 protein	28973502
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of TUBB3 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of TUBB3 mRNA	19244175
C078903	seocalcitol	seocalcitol results in increased expression of TUBB3 mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of TUBB3 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TUBB3 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TUBB3 mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in increased expression of TUBB3 mRNA	20308225
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of TUBB3 mRNA]"	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of TUBB3 mRNA	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of TUBB3 protein	22641621
C105686	SU 5402	"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA"	20865013
C061133	tamibarotene	tamibarotene results in increased expression of TUBB3	19182380
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]	19466750
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TUBB3 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TUBB3 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUBB3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TUBB3 mRNA	17942748
D019284	Thapsigargin	Thapsigargin results in decreased expression of TUBB3 mRNA	22378314
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TUBB3 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of TUBB3 protein	23396223
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to TUBB3 gene]	26655721
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to TUBB3 promoter]	26655721
D014212	Tretinoin	Tretinoin results in increased expression of TUBB3 mRNA	23903816\|2665572
D014212	Tretinoin	Tretinoin results in increased expression of TUBB3 protein	16646664
D014212	Tretinoin	ZMYND8 protein affects the reaction [Tretinoin results in increased expression of TUBB3 mRNA]	26655721
D014212	Tretinoin	AKT1 protein inhibits the reaction [Tretinoin results in increased expression of TUBB3 protein]	16613989
D014212	Tretinoin	DKK1 protein promotes the reaction [Tretinoin results in increased expression of TUBB3 protein]	17064353
D014212	Tretinoin	FGF2 protein promotes the reaction [Tretinoin results in increased expression of TUBB3 protein]	16009726
D014212	Tretinoin	Tretinoin results in increased expression of TUBB3 protein	16009726\|1661398
D014212	Tretinoin	Tretinoin results in decreased expression of TUBB3 mRNA	20488242\|2497733
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of TUBB3 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TUBB3 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of TUBB3 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of TUBB3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of TUBB3 mRNA	25979313\|2607246
D014635	Valproic Acid	Valproic Acid results in decreased expression of TUBB3	25524013
D014635	Valproic Acid	Valproic Acid results in decreased expression of TUBB3 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of TUBB3 protein	18599177
D014635	Valproic Acid	Valproic Acid results in increased expression of TUBB3 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of TUBB3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of TUBB3 mRNA	17292431\|2607246
D014635	Valproic Acid	Valproic Acid results in decreased expression of TUBB3 mRNA	24896083
D014635	Valproic Acid	Valproic Acid results in increased expression of TUBB3 mRNA	19136453
D014635	Valproic Acid	Valproic Acid affects the expression of TUBB3 protein	19460635
D000068756	Valsartan	Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]	17068200
D014750	Vincristine	Vincristine results in decreased expression of TUBB3 mRNA	23649840
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of TUBB3 mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of TUBB3 mRNA	19244175
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TUBB3 mRNA	27935865
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of TUBB3 mRNA	18593933
D015032	Zinc	Zinc deficiency results in increased expression of TUBB3 mRNA	19111725
C088658	zoledronic acid	zoledronic acid results in decreased expression of TUBB3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IEA	-
GO:0005200	structural constituent of cytoskeleton	-	IBA	21873635
GO:0005200	structural constituent of cytoskeleton	-	IEA	-
GO:0005515	protein binding	-	IPI	21044950 24021646
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IEA	-
GO:0042277	peptide binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000226	microtubule cytoskeleton organization	-	IBA	21873635
GO:0000278	mitotic cell cycle	-	IBA	21873635
GO:0000278	mitotic cell cycle	-	IEA	-
GO:0007010	cytoskeleton organization	-	IEA	-
GO:0007017	microtubule-based process	-	IBA	21873635
GO:0007017	microtubule-based process	-	IEA	-
GO:0007411	axon guidance	-	IBA	21873635
GO:0007411	axon guidance	-	IMP	20074521
GO:0030182	neuron differentiation	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IEA	-
GO:0005874	microtubule	-	IBA	21873635
GO:0005874	microtubule	-	IDA	21525035
GO:0030424	axon	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0071944	cell periphery	-	IEA	-

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04540	Gap junction
hsa05130	Pathogenic Escherichia coli infection

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-157858	Gap junction trafficking and regulation	IEA
R-HSA-157858	Gap junction trafficking and regulation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-190828	Gap junction trafficking	IEA
R-HSA-190828	Gap junction trafficking	TAS
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	TAS
R-HSA-190861	Gap junction assembly	IEA
R-HSA-190861	Gap junction assembly	TAS
R-HSA-190872	Transport of connexons to the plasma membrane	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-373760	L1CAM interactions	TAS
R-HSA-373760	L1CAM interactions	IEA
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	IEA
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	IEA
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	IEA
R-HSA-389977	Post-chaperonin tubulin folding pathway	IEA
R-HSA-390466	Chaperonin-mediated protein folding	IEA
R-HSA-391251	Protein folding	IEA
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-437239	Recycling pathway of L1	TAS
R-HSA-437239	Recycling pathway of L1	IEA
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620924	Intraflagellar transport	TAS
R-HSA-5626467	RHO GTPases activate IQGAPs	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-597592	Post-translational protein modification	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	IEA
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS
R-HSA-983189	Kinesins	TAS
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24994038	Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer. (2014 Dec)	Deng LL	J Cancer Res Clin Oncol
27988838	Polymorphisms of Genes Encoding Multidrug Resistance Proteins as a Predictive Factor for Second-Line Docetaxel Therapy in Advanced Non-small Cell Lung Cancer. (2017 Jul)	Szczyrek M	Pathol Oncol Res
25366782	Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer. (2014 Oct 31)	Han Y	Genet Mol Res