Gene: ADARB1

104
ADAR2|DRABA2|DRADA2|RED1
adenosine deaminase, RNA specific B1
protein-coding
21q22.3
Ensembl:ENSG00000197381 MIM:601218 Vega:OTTHUMG00000090295 UniprotKB:P78563
NG_052015.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.563e-1 (AD)  3.311e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3788164chr21:45136301 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01716252chr21:46552605ADARB11.300e-11Smoking27651444
cg22635096chr21:46550644ADARB17.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INPP4A0.968
KIAA1549L0.962
DLG30.961
RBFOX20.959
ADD20.958
AAK10.957
UNC13A0.957
SLC12A50.957
MYT1L0.956
PAK10.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.574
HEY2-0.547
REST-0.542
SNHG18-0.541
YES1-0.538
RAI14-0.532
RAB13-0.529
COPZ2-0.52
CSAG1-0.515
ROM1-0.514

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADARB1 mRNA19933214
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of ADARB1 mRNA"21724226
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ADARB1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of ADARB1 mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADARB1 mRNA22100608
C000188alachloralachlor results in increased expression of ADARB1 mRNA12419858
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ADARB1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADARB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ADARB1 mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in decreased expression of ADARB1 mRNA16704987
C015001arsenitearsenite results in increased methylation of ADARB1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of ADARB1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADARB1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADARB1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADARB1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ADARB1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ADARB1 mRNA22576693|2927551
C006780bisphenol Abisphenol A results in increased methylation of ADARB1 gene22576693
C006780bisphenol Abisphenol A affects the expression of ADARB1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ADARB1 mRNA25181051
D002110CaffeineCaffeine results in decreased expression of ADARB1 mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADARB1 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of ADARB1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADARB1 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of ADARB1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ADARB1 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ADARB1 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of ADARB1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADARB1 mRNA17361019
D004026DieldrinDieldrin results in increased expression of ADARB1 mRNA28385952
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ADARB1 mRNA"27840820
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADARB1 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADARB1 mRNA17942748
D018683Excitatory Amino Acid AgentsADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]21320410
D018683Excitatory Amino Acid AgentsADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]21320410
D005473FluoxetineADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]21320410
D005473FluoxetineADARB1 protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]21320410
D005473FluoxetineADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]21320410
D005473FluoxetineADARB1 protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]21320410
D005473FluoxetineFluoxetine results in increased expression of ADARB1 mRNA21320410
D005473FluoxetineFluoxetine results in increased expression of ADARB1 protein21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]21320410
C069837fullerene C60fullerene C60 results in decreased expression of ADARB1 mRNA19167457
D019833GenisteinGenistein results in increased expression of ADARB1 mRNA22228119
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADARB1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ADARB1 mRNA24796395|2530787
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of ADARB1 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADARB1 mRNA20864626
C059539midostaurinmidostaurin results in decreased expression of ADARB1 mRNA20980353
D008942MitoxantroneADARB1 protein affects the susceptibility to Mitoxantrone16217747
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of ADARB1 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ADARB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADARB1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ADARB1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADARB1 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADARB1 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of ADARB1 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADARB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADARB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ADARB1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ADARB1 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADARB1 mRNA24780913
D011748PyrogallolPyrogallol results in decreased expression of ADARB1 mRNA20362636
C009277sodium arsenatesodium arsenate results in decreased expression of ADARB1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of ADARB1 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADARB1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADARB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADARB1 mRNA16962184|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADARB1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ADARB1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADARB1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ADARB1 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ADARB1 mRNA21934132
C034613triacsin Ctriacsin C results in decreased expression of ADARB1 mRNA16704987
C012589trichostatin Atrichostatin A affects the expression of ADARB1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ADARB1 mRNA27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ADARB1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of ADARB1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of ADARB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ADARB1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased methylation of ADARB1 gene29154799
D014638VanadatesVanadates results in decreased expression of ADARB1 mRNA22714537
D002762CholecalciferolCholecalciferol results in increased expression of ADARB1 mRNA16508948
D014810Vitamin EVitamin E results in decreased expression of ADARB1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003726double-stranded RNA adenosine deaminase activity-IBA21873635  
GO:0003726double-stranded RNA adenosine deaminase activity-TAS-  
GO:0003729mRNA binding-TAS9149227  
GO:0005515protein binding-IPI21847096  
GO:0008251tRNA-specific adenosine deaminase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006382adenosine to inosine editing-IBA21873635  
GO:0006382adenosine to inosine editing-IDA18178553  21289159  
GO:0006382adenosine to inosine editing-TAS-  
GO:0006396RNA processing-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO:0007274neuromuscular synaptic transmission-IEA-  
GO:0008285negative regulation of cell proliferation-IDA18178553  
GO:0021610facial nerve morphogenesis-IEA-  
GO:0021618hypoglossal nerve morphogenesis-IEA-  
GO:0021965spinal cord ventral commissure morphogenesis-IEA-  
GO:0030336negative regulation of cell migration-IDA18178553  
GO:0035264multicellular organism growth-IEA-  
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation-IDA21289159  
GO:0045070positive regulation of viral genome replication-IMP21289159  
GO:0045087innate immune response-IEA-  
GO:0050884neuromuscular process controlling posture-IEA-  
GO:0051607defense response to virus-IEA-  
GO:0051726regulation of cell cycle-IDA18178553  
GO:0060384innervation-IEA-  
GO:0060415muscle tissue morphogenesis-IEA-  
GO:0061744motor behavior-IEA-  
GO:0097049motor neuron apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA18178553  21289159  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-75064mRNA Editing: A to I ConversionTAS
R-HSA-75072mRNA EditingTAS
R-HSA-75102C6 deamination of adenosineTAS
R-HSA-77042Formation of editosomes by ADAR proteinsTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal