Gene: PEMT

10400
PEAMT|PEMPT|PEMT2|PLMT|PNMT
phosphatidylethanolamine N-methyltransferase
protein-coding
17p11.2
Ensembl:ENSG00000133027 MIM:602391 Vega:OTTHUMG00000059290 UniprotKB:Q9UBM1
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.009e-1 (AD)  9.259e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPE0.893
SIVA10.874
TMEM2080.862
TXN20.861
NDUFAF30.859
PHPT10.858
AURKAIP10.857
TMEM120A0.857
NDUFA70.856
PSENEN0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.68
OR4F29-0.632
SFTPA1-0.33
KRT73-0.326
ZC3H11B-0.322
FER1L6-0.318
PZP-0.317
SFTPB-0.312
HMCN1-0.311
MTRNR2L9-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PEMT mRNA"21346803
C0293704-toluidine4-toluidine results in decreased expression of PEMT mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of PEMT mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of PEMT mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PEMT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PEMT mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PEMT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PEMT mRNA19770486
D001151ArsenicPEMT gene SNP affects the susceptibility to Arsenic25759212
D001280AtrazineAtrazine results in decreased expression of PEMT mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PEMT mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PEMT mRNA19770486
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PEMT mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of PEMT mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PEMT mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PEMT mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PEMT mRNA23741332
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PEMT mRNA23650126
D002794CholinePEMT gene SNP affects the susceptibility to Choline17616785
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PEMT mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of PEMT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PEMT mRNA]17585979
D002995Clofibric AcidClofibric Acid affects the expression of PEMT mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PEMT mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of PEMT mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of PEMT mRNA19770486
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PEMT mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PEMT mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of PEMT mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PEMT mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PEMT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PEMT mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PEMT mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of PEMT mRNA25572481
D005557FormaldehydeFormaldehyde results in decreased expression of PEMT mRNA23649840
D007213IndomethacinIndomethacin results in increased expression of PEMT mRNA28201806
C544151jinfukangjinfukang results in increased expression of PEMT mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PEMT mRNA22904298|2343069
C410337K 7174K 7174 results in decreased expression of PEMT mRNA24086573
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of PEMT mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of PEMT mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PEMT mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PEMT mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PEMT mRNA"26251327
D015735MifepristoneMifepristone results in decreased expression of PEMT mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PEMT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PEMT mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of PEMT mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PEMT mRNA17681415
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEMT mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PEMT mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of PEMT mRNA24677778
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PEMT mRNA22714537
D017035PravastatinPravastatin results in decreased expression of PEMT mRNA27225895
D017035PravastatinPravastatin results in decreased expression of PEMT mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PEMT mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PEMT mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of PEMT mRNA20864642
D012524SarinSarin results in decreased expression of PEMT mRNA19522546
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of PEMT mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of PEMT mRNA19564919
C075117squalestatin 1squalestatin 1 results in decreased expression of PEMT mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of PEMT mRNA27225895
D013311StreptozocinStreptozocin affects the expression of PEMT mRNA18583417
D013311StreptozocinStreptozocin results in increased activity of PEMT protein16835399
D013629TamoxifenTamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA]20150657|2015065
D013629TamoxifenTamoxifen results in decreased expression of PEMT mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEMT mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PEMT gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PEMT promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEMT mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEMT mRNA16054898|1696003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEMT mRNA26232522
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PEMT mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of PEMT mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PEMT mRNA23557971
D014212TretinoinTretinoin results in decreased expression of PEMT mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PEMT mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PEMT mRNA19448997
C057693troglitazonetroglitazone results in increased expression of PEMT mRNA25572481
C057693troglitazonetroglitazone results in decreased expression of PEMT mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of PEMT mRNA12732648
D014635Valproic AcidValproic Acid affects the expression of PEMT mRNA25979313
D014810Vitamin EVitamin E results in increased expression of PEMT mRNA19244175
D015032ZincZinc results in increased expression of PEMT mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000773phosphatidyl-N-methylethanolamine N-methyltransferase activity-IEA-  
GO:0004608phosphatidylethanolamine N-methyltransferase activity-IBA21873635  
GO:0004608phosphatidylethanolamine N-methyltransferase activity-TAS-  
GO:0008429phosphatidylethanolamine binding-IEA-  
GO:0080101phosphatidyl-N-dimethylethanolamine N-methyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS9989271  
GO:0006656phosphatidylcholine biosynthetic process-IBA21873635  
GO:0006656phosphatidylcholine biosynthetic process-IEA-  
GO:0006656phosphatidylcholine biosynthetic process-TAS-  
GO:0006686sphingomyelin biosynthetic process-IEA-  
GO:0008283cell proliferation-TAS9989271  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0032259methylation-IEA-  
GO:0033273response to vitamin-IEA-  
GO:0043200response to amino acid-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0046498S-adenosylhomocysteine metabolic process-IEA-  
GO:0046500S-adenosylmethionine metabolic process-IEA-  
GO:0050747positive regulation of lipoprotein metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031526brush border membrane-IEA-  
GO:0031966mitochondrial membrane-IEA-  
GO:0042383sarcolemma-IEA-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483191Synthesis of PCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26728177Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents. (2016 Apr)Nilsson TKFASEB J
11192332Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. (2000 Dec)Lieber CSCrit Rev Clin Lab Sci