Gene: PIAS3

10401
ZMIZ5
protein inhibitor of activated STAT 3
protein-coding
1q21.1
Ensembl:ENSG00000131788 MIM:605987 Vega:OTTHUMG00000013750 UniprotKB:Q9Y6X2
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.715e-1 (AD)  2.403e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNRNP2000.901
ARNT0.896
ANKFY10.894
ASXL10.891
DCAF50.891
CNOT10.89
NFATC2IP0.89
TAF10.888
FKBP150.885
NONO0.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.615
OR4F29-0.584
KLRC2-0.248
MTRNR2L6-0.227
MTRNR2L9-0.214
OR4F16-0.212
NANOGNB-0.207
MTRNR2L10-0.189
HMHB1-0.18
MOGAT2-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PIAS3 mRNA"28903501
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PIAS3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PIAS3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIAS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIAS3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PIAS3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PIAS3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PIAS3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PIAS3 mRNA19770486
D019386AlendronateAlendronate affects the expression of PIAS3 mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PIAS3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PIAS3 mRNA24449571
D001280AtrazineAtrazine results in increased expression of PIAS3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PIAS3 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of PIAS3 mRNA16029874
C006780bisphenol Abisphenol A results in increased expression of PIAS3 mRNA28196854
C006780bisphenol Abisphenol A results in decreased expression of PIAS3 mRNA12075121
C584509C646 compoundC646 compound results in decreased expression of PIAS3 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of PIAS3 mRNA25979313
D002922CiguatoxinsCiguatoxins affects the expression of PIAS3 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of PIAS3 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of PIAS3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PIAS3 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of PIAS3 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PIAS3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of PIAS3 mRNA27392435
C588213DSF-27 compoundDSF-27 compound results in increased expression of PIAS324486434
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PIAS3 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PIAS3 mRNA12075121
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PIAS3 mRNA23649840
D019833GenisteinGenistein results in decreased expression of PIAS3 mRNA12075121
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIAS3 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PIAS3 mRNA23649840
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of PIAS3 mRNA19716841
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PIAS3 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of PIAS3 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PIAS3 mRNA28903501
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PIAS3 mRNA16079270
C059514resveratrolresveratrol affects the localization of PIAS3 protein22096581
C059514resveratrolresveratrol results in increased expression of PIAS3 mRNA25061499|2643204
C059514resveratrolresveratrol results in increased expression of PIAS3 protein25061499|2643204
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of PIAS3 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIAS3 mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIAS3 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIAS3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIAS3 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PIAS3 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PIAS3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of PIAS3 mRNA25729387
D014520UrethaneUrethane results in increased expression of PIAS3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIAS3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PIAS3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PIAS3 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of PIAS3 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of PIAS3 mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PIAS3 gene25560391
C111237vorinostatvorinostat results in decreased expression of PIAS3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11060035  17066076  21965678  
GO:0008022protein C-terminus binding-IPI14715251  
GO:0008270zinc ion binding-IEA-  
GO:0015459potassium channel regulator activity-IEA-  
GO:0019789SUMO transferase activity-EXP15507434  21965678  
GO:0019899enzyme binding-IPI17087506  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0009725response to hormone-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0016925protein sumoylation-IEA-  
GO:0016925protein sumoylation-ISS-  
GO:0016925protein sumoylation-TAS-  
GO:0033234negative regulation of protein sumoylation-IDA24651376  
GO:0033235positive regulation of protein sumoylation-IDA17696781  21965678  
GO:0045671negative regulation of osteoclast differentiation-IEA-  
GO:0045838positive regulation of membrane potential-IEA-  
GO:0071847TNFSF11-mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IEA-  
GO:0030425dendrite-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04630Jak-STAT signaling pathway
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25137041Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. (2014)Pastuszak-Lewandoska DPLoS One