Gene: ST3GAL6

10402
SIAT10|ST3GALVI
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
protein-coding
3q12.1
Ensembl:ENSG00000064225 MIM:607156 Vega:OTTHUMG00000159047 UniprotKB:Q9Y274
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.137e-1 (AD)  8.885e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NGLY10.871
LGALS80.854
C2CD50.847
C10orf880.846
DCBLD20.845
MSL30.844
SLC25A360.842
RUNDC3B0.84
ARMC80.836
RABGAP1L0.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.466
OR4F5-0.452
OR4F29-0.433
NKAIN3-0.421
AQP5-0.415
ASB4-0.405
CYP11A1-0.394
LHFPL1-0.391
HOGA1-0.383
EYA2-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ST3GAL6 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of ST3GAL6 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ST3GAL6 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL6 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ST3GAL6 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of ST3GAL6 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ST3GAL6 gene27153756
D000638AmiodaroneAmiodarone affects the expression of ST3GAL6 mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ST3GAL6 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ST3GAL6 mRNA"25351596
D001280AtrazineAtrazine results in decreased expression of ST3GAL6 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of ST3GAL6 mRNA19194470
D001553BenzbromaroneBenzbromarone affects the expression of ST3GAL6 mRNA19483382
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of ST3GAL6 mRNA19737606
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ST3GAL6 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ST3GAL6 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of ST3GAL6 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ST3GAL6 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ST3GAL6 mRNA22079614
D002994ClofibrateClofibrate affects the expression of ST3GAL6 mRNA16081524
D002994ClofibrateClofibrate affects the expression of ST3GAL6 mRNA19483382
D003042CocaineCocaine results in increased expression of ST3GAL6 mRNA12629581
D019327Copper SulfateCopper Sulfate results in decreased expression of ST3GAL6 mRNA19549813
D016578Crack CocaineCrack Cocaine results in decreased expression of ST3GAL6 mRNA12629581
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL6 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of ST3GAL6 mRNA21198554
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of ST3GAL6 mRNA]21095227
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ST3GAL6 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ST3GAL6 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of ST3GAL6 mRNA28031460
D004041Dietary FatsDietary Fats results in increased expression of ST3GAL6 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of ST3GAL6 mRNA]19030233
D002117CalcitriolCalcitriol results in increased expression of ST3GAL6 mRNA16002434
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of ST3GAL6 mRNA27638505
D005001EthionineEthionine affects the expression of ST3GAL6 mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ST3GAL6 mRNA23649840
C039281furanfuran results in decreased expression of ST3GAL6 mRNA26194646
D017313FenretinideFenretinide results in increased expression of ST3GAL6 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ST3GAL6 mRNA25613284
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ST3GAL6 mRNA25119042
C045463leflunomideleflunomide results in increased expression of ST3GAL6 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ST3GAL6 mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ST3GAL6 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST3GAL6 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ST3GAL6 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ST3GAL6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ST3GAL6 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ST3GAL6 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of ST3GAL6 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of ST3GAL6 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of ST3GAL6 mRNA19483382
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ST3GAL6 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ST3GAL6 mRNA25119042
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of ST3GAL6 mRNA28973697
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ST3GAL6 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of ST3GAL6 mRNA17426115|1830175
C006253pirinixic acidpirinixic acid affects the expression of ST3GAL6 mRNA19483382
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ST3GAL6 mRNA21334430
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ST3GAL6 mRNA20660070
D011441PropylthiouracilPropylthiouracil affects the expression of ST3GAL6 mRNA19483382
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of ST3GAL6 mRNA19194470
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of ST3GAL6 mRNA]19030233
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ST3GAL6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ST3GAL6 mRNA25351596
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of ST3GAL6 mRNA]21095227
C017947sodium arsenitesodium arsenite affects the methylation of ST3GAL6 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of ST3GAL6 mRNA22714537|2859598
D018038Sodium SeleniteSodium Selenite results in decreased expression of ST3GAL6 mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ST3GAL6 mRNA21641980
D013739TestosteroneTestosterone results in decreased expression of ST3GAL6 mRNA21669218
C004648testosterone enanthatetestosterone enanthate affects the expression of ST3GAL6 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST3GAL6 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL6 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST3GAL6 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL6 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ST3GAL6 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ST3GAL6 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ST3GAL6 mRNA20133372
D014212TretinoinTretinoin results in increased expression of ST3GAL6 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ST3GAL6 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ST3GAL6 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ST3GAL6 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ST3GAL6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ST3GAL6 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of ST3GAL6 mRNA29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of ST3GAL6 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-TAS-  
GO:0052798beta-galactoside alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0052798beta-galactoside alpha-2,3-sialyltransferase activity-IDA10206952  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-IDA10206952  
GO:0006664glycolipid metabolic process-IDA10206952  
GO:0009311oligosaccharide metabolic process-IDA10206952  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0071354cellular response to interleukin-6-IEP17944600  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016021integral component of membrane-NAS10206952  
GO:0070062extracellular exosome-HDA19199708  23533145  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27704662Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. (2016 Dec)Nio-Kobayashi JMol Reprod Dev