Gene: CPQ

10404
LDP|PGCP
carboxypeptidase Q
protein-coding
8q22.1
Ensembl:ENSG00000104324 Vega:OTTHUMG00000164690 UniprotKB:Q9Y646
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.595e-1 (AD)  2.192e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12675345chr8:96673363 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HDAC10.869
GSN0.862
ATP6V0E10.855
MTMR100.853
SYPL10.851
QKI0.851
DERA0.848
PMP220.846
PTTG1IP0.846
CYP27A10.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.526
CALHM1-0.525
GABRG3-0.523
PRSS12-0.518
ADRA1D-0.517
FBLN7-0.515
RTP1-0.511
GPR68-0.51
MCHR1-0.509
KCNB2-0.504

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of CPQ mRNA"17070881
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CPQ mRNA"19162173
C0353141-nitropropane1-nitropropane results in decreased expression of CPQ mRNA17070881
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of CPQ mRNA"17070881
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CPQ mRNA"21346803
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of CPQ mRNA"17070881
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CPQ mRNA"21346803
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of CPQ mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of CPQ mRNA17070881
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CPQ mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPQ mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of CPQ mRNA17070881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPQ mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CPQ mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CPQ protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CPQ mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CPQ mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CPQ protein26597043
D000638AmiodaroneAmiodarone affects the expression of CPQ mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CPQ mRNA16483693
D001280AtrazineAtrazine results in increased expression of CPQ mRNA18522720
D001280AtrazineAtrazine results in increased expression of CPQ mRNA22982499
C547126AZM551248AZM551248 results in decreased expression of CPQ mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of CPQ mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPQ mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPQ mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPQ mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of CPQ protein28279065
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CPQ mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CPQ mRNA17484886
D002994ClofibrateClofibrate affects the expression of CPQ mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of CPQ mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CPQ mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of CPQ mRNA19770486
D000069439DasatinibDasatinib results in increased expression of CPQ mRNA20579391
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CPQ mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CPQ mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CPQ mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CPQ mRNA19041683|1963824
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CPQ mRNA25380136
D005001EthionineEthionine affects the expression of CPQ mRNA19483382
D005419FlavonoidsFlavonoids results in decreased expression of CPQ mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of CPQ mRNA17070881
C039281furanfuran results in decreased expression of CPQ mRNA25539665
C039281furanfuran results in increased methylation of CPQ gene22079235
D005839GentamicinsGentamicins results in decreased expression of CPQ protein22061828
C010176halofuginonehalofuginone results in decreased expression of CPQ mRNA17180598
D017313FenretinideFenretinide results in decreased expression of CPQ mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPQ mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CPQ mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CPQ mRNA23086925
D007657Ketone BodiesKetone Bodies results in decreased expression of CPQ mRNA16807920
D007854LeadLead affects the expression of CPQ mRNA28903495
C523799MRK 003MRK 003 results in decreased expression of CPQ mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPQ mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPQ mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CPQ mRNA25380136
D009532NickelNickel results in decreased expression of CPQ mRNA24768652
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of CPQ protein19716841
D009853OmeprazoleOmeprazole affects the expression of CPQ mRNA19483382
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CPQ mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPQ mRNA"27188386
C006253pirinixic acidpirinixic acid affects the expression of CPQ mRNA19483382
D011374ProgesteroneCPQ gene SNP affects the susceptibility to Progesterone25622337
D011441PropylthiouracilPropylthiouracil affects the expression of CPQ mRNA19483382
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CPQ mRNA27029645
D011794QuercetinQuercetin results in decreased expression of CPQ mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPQ mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of CPQ mRNA22561333
C016104sodium bichromatesodium bichromate results in decreased expression of CPQ mRNA25993096
C016104sodium bichromatesodium bichromate results in increased expression of CPQ mRNA22561333
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CPQ mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPQ mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPQ mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPQ mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of CPQ mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of CPQ mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CPQ mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of CPQ gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CPQ mRNA28001369
D015032ZincZinc deficiency results in increased expression of CPQ mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004180carboxypeptidase activity-IEA-  
GO:0042803protein homodimerization activity-IDA12675526  
GO:0046872metal ion binding-IEA-  
GO:0070573metallodipeptidase activity-IBA21873635  
GO:0070573metallodipeptidase activity-IDA10206990  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IDA10206990  
GO:0006590thyroid hormone generation-IBA21873635  
GO:0006590thyroid hormone generation-ISS-  
GO:0042246tissue regeneration-ISS-  
GO:0043171peptide catabolic process-IBA21873635  
GO:0043171peptide catabolic process-IDA10206990  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA10206990  
GO:0005737cytoplasm-IDA10206990  
GO:0005764lysosome-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005794Golgi apparatus-IDA-  
GO:0005794Golgi apparatus-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal