Gene: WFDC2

10406
EDDM4|HE4|WAP5|dJ461P17.6
WAP four-disulfide core domain 2
protein-coding
20q13.12
Ensembl:ENSG00000101443 MIM:617548 Vega:OTTHUMG00000032594 UniprotKB:Q14508
NC_000020.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.348e-2 (AD)  9.579e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMC90.746
ASS10.743
FNDC40.741
MARCH90.739
PPM1J0.736
PTGES20.733
ARF50.731
SDHAF10.729
NCBP2-AS20.729
PIN10.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.497
OR4F29-0.443
CTNNA3-0.345
KIAA0754-0.343
TRPV5-0.333
REST-0.318
FYCO1-0.309
RAI14-0.305
CRYBG3-0.288
YES1-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of WFDC2 mRNA"21354444
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of WFDC2 mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of WFDC2 mRNA26821219
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of WFDC2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of WFDC2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of WFDC2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WFDC2 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WFDC2 mRNA16483693
D001151ArsenicArsenic affects the methylation of WFDC2 gene25304211
D001194AsbestosAsbestos affects the expression of WFDC2 mRNA17297452
C547126AZM551248AZM551248 results in decreased expression of WFDC2 mRNA22323515
C487081belinostatbelinostat results in increased expression of WFDC2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of WFDC2 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WFDC2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WFDC2 mRNA27195522
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of WFDC2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of WFDC2 mRNA15289156|1948475
C006780bisphenol Abisphenol A affects the expression of WFDC2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of WFDC2 mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WFDC2 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of WFDC2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of WFDC2 mRNA17553155
C018021cobaltous chloridecobaltous chloride results in decreased expression of WFDC2 mRNA24386269
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of WFDC2 mRNA15467011
C014347decitabinedecitabine affects the expression of WFDC2 mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of WFDC2 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of WFDC2 gene22964155
D002945CisplatinCisplatin affects the expression of WFDC2 mRNA23300844
D002945CisplatinWFDC2 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats affects the expression of WFDC2 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of WFDC2 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of WFDC2 mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of WFDC2 mRNA15171707
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of WFDC2 mRNA15289156
D002117CalcitriolCalcitriol results in increased expression of WFDC2 mRNA26485663
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of WFDC2 mRNA25380136
D004237DiuronDiuron results in decreased expression of WFDC2 mRNA21551480
C118739entinostatentinostat results in increased expression of WFDC2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D000431EthanolEthanol results in increased expression of WFDC2 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WFDC2 mRNA17555576
D004397FonofosFonofos results in increased methylation of WFDC2 promoter22847954
D019833GenisteinGenistein results in increased expression of WFDC2 mRNA15289156
D006533HeptachlorHeptachlor results in decreased expression of WFDC2 mRNA23153324
D017313FenretinideFenretinide results in increased expression of WFDC2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WFDC2 mRNA25613284
D007559IvermectinIvermectin results in decreased expression of WFDC2 mRNA26443706
D007854LeadLead affects the expression of WFDC2 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of WFDC2 mRNA27339419
D015122MercaptopurineMercaptopurine results in decreased expression of WFDC2 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of WFDC2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WFDC2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of WFDC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased secretion of WFDC2 protein"25598225
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of WFDC2 mRNA26821219
D000073878Palm OilPalm Oil affects the expression of WFDC2 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of WFDC2 mRNA26272509
D010278ParathionParathion results in increased methylation of WFDC2 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of WFDC2 protein17520064
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of WFDC2 mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of WFDC2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of WFDC2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of WFDC2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of WFDC2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of WFDC2 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of WFDC2 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of WFDC2 mRNA23811191
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of WFDC2 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of WFDC2 mRNA21540246
D011374ProgesteroneProgesterone results in decreased expression of WFDC2 mRNA19690047
C045950propiconazolepropiconazole results in decreased expression of WFDC2 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of WFDC2 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of WFDC2 mRNA25626140
C059514resveratrolresveratrol results in increased expression of WFDC2 mRNA17257620
D012643SeleniumSelenium results in increased expression of WFDC2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of WFDC2 mRNA25895662
D012906SmokeSmoke results in decreased expression of WFDC2 mRNA21095227
D012906SmokeSmoke affects the expression of WFDC2 mRNA23693141
C013698tallowtallow affects the expression of WFDC2 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of WFDC2 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of WFDC2 mRNA25123088
C021751tanshinonetanshinone results in increased expression of WFDC2 mRNA15849732
C012568terbufosterbufos results in increased methylation of WFDC2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WFDC2 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WFDC2 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WFDC2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WFDC2 mRNA25613284
D014050TolueneToluene results in decreased expression of WFDC2 mRNA22967744
D014212TretinoinTretinoin results in increased expression of WFDC2 mRNA16249480
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of WFDC2 mRNA24935251|2627250
D014501UraniumUranium affects the expression of WFDC2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of WFDC2 mRNA15672453
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WFDC2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WFDC2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WFDC2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of WFDC2 gene29154799
D014640VancomycinVancomycin results in decreased expression of WFDC2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of WFDC2 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of WFDC2 protein17520064
C025643vinclozolinvinclozolin affects the expression of WFDC2 mRNA19015723
D014810Vitamin EVitamin E results in increased expression of WFDC2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS1686187  
GO:0004867serine-type endopeptidase inhibitor activity-IDA23139753  
GO:0004869cysteine-type endopeptidase inhibitor activity-IEA-  
GO:0019828aspartic-type endopeptidase inhibitor activity-IDA23139753  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-TAS1686187  
GO:0007283spermatogenesis-TAS1686187  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS1686187  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27224553HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure. (2017 Jan)Piek AJ Card Fail