Gene: IFITM3

10410
1-8U|DSPA2b|IP15
interferon induced transmembrane protein 3
protein-coding
11p15.5
Ensembl:ENSG00000142089 MIM:605579 Vega:OTTHUMG00000165542 UniprotKB:Q01628
NG_032755.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.815e-1 (AD)  3.390e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17990365chr11:319718IFITM32.000e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IFITM20.938
RHOC0.901
PXDC10.891
TMBIM10.885
TAGLN20.884
TNFRSF1A0.879
MYL12A0.874
RAB130.873
VAMP50.87
LTBR0.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.589
PPEF1-0.578
NEUROD6-0.56
SLC7A4-0.557
ADRA1D-0.55
MARCH4-0.545
GPR61-0.543
XKR4-0.541
CALHM1-0.54
NXPH2-0.537

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IFITM3 mRNA"19162173
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of IFITM3 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFITM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFITM3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IFITM3 mRNA22230336|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of IFITM3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IFITM3 mRNA]17585979
C430898AGN 194204AGN 194204 results in decreased expression of IFITM3 mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IFITM3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IFITM3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of IFITM3 mRNA20458559
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of IFITM3 mRNA26271895
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of IFITM3 protein26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFITM3 mRNA19770486
D004958EstradiolEstradiol results in increased expression of IFITM3 mRNA19484750
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IFITM3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of IFITM3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IFITM3 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of IFITM3 mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of IFITM3 mRNA14729362|1500399
C584509C646 compoundC646 compound results in increased expression of IFITM3 mRNA26191083
D002104CadmiumCadmium results in increased expression of IFITM3 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IFITM3 mRNA21457566
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IFITM3 mRNA25993096
C459604candoxincandoxin results in decreased expression of IFITM3 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IFITM3 mRNA17484886
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of IFITM3 mRNA]"22079312
C100187chloropicrinchloropicrin results in decreased expression of IFITM3 mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of IFITM3 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of IFITM3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IFITM3 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of IFITM3 mRNA24386269
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of IFITM3 mRNA15467011
D003471CuprizoneCuprizone results in increased expression of IFITM3 mRNA26577399
C014347decitabinedecitabine results in increased expression of IFITM3 mRNA19151715
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IFITM3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IFITM3 mRNA28628672
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of IFITM3 mRNA26271895
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of IFITM3 protein26271895
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of IFITM3 mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of IFITM3 mRNA"22079312
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IFITM3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of IFITM3 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of IFITM3 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of IFITM3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of IFITM3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of IFITM3 mRNA18503570
D004237DiuronDiuron metabolite results in increased expression of IFITM3 mRNA24172598
D004237DiuronDiuron results in decreased expression of IFITM3 mRNA25152437
C118739entinostatentinostat results in increased expression of IFITM3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFITM3 mRNA"27188386
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of IFITM3 mRNA27720938
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IFITM3 mRNA17557909
D015025ZearalenoneZearalenone results in decreased expression of IFITM3 mRNA19371625
D018120FinasterideFinasteride results in decreased expression of IFITM3 mRNA24136188
D005492Folic AcidFolic Acid results in decreased expression of IFITM3 mRNA11723236
D019833GenisteinGenistein results in decreased expression of IFITM3 mRNA19371625
D005897GlafenineGlafenine results in increased expression of IFITM3 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of IFITM3 mRNA14729362
C492448ICG 001ICG 001 results in increased expression of IFITM3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IFITM3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IFITM3 mRNA28628672
C051890irinotecanirinotecan results in increased expression of IFITM3 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IFITM3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IFITM3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IFITM3 mRNA23086925
D008727MethotrexateMethotrexate results in decreased expression of IFITM3 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IFITM3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IFITM3 mRNA"25554681
D009532NickelNickel results in increased expression of IFITM3 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of IFITM3 mRNA22110744
C025589ochratoxin Aochratoxin A results in increased acetylation of IFITM3 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of IFITM3 promoter] which results in increased expression of IFITM3 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of IFITM3 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IFITM3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IFITM3 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IFITM3 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of IFITM3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of IFITM3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IFITM3 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IFITM3 mRNA]17655762
D000073878Palm OilPalm Oil results in decreased expression of IFITM3 mRNA18042831
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of IFITM3 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of IFITM3 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IFITM3 mRNA]17655762
D010416PentachlorophenolPentachlorophenol results in increased expression of IFITM3 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of IFITM3 protein26178269
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of IFITM3 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IFITM3 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of IFITM3 mRNA19159669
C006253pirinixic acidpirinixic acid results in decreased expression of IFITM3 mRNA17950772|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of IFITM3 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of IFITM3 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of IFITM3 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IFITM3 mRNA27029645
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of IFITM3 mRNA25905778
C059514resveratrolresveratrol results in decreased expression of IFITM3 mRNA19228061
D012643SeleniumSelenium results in increased expression of IFITM3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IFITM3 mRNA25895662
D012834SilverSilver results in decreased expression of IFITM3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of IFITM3 mRNA12727804
D012999SomanSoman results in increased expression of IFITM3 mRNA19281266
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of IFITM3 mRNA25905778
D013467SulindacSulindac results in decreased expression of IFITM3 mRNA24136188
C025462sulindac sulfidesulindac sulfide results in decreased expression of IFITM3 mRNA16184548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFITM3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFITM3 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IFITM3 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of IFITM3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IFITM3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IFITM3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IFITM3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of IFITM3 mRNA23724009
C011559tributyltintributyltin results in increased expression of IFITM3 mRNA21683754
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IFITM3 mRNA17982090
C406224valdecoxibvaldecoxib results in increased expression of IFITM3 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of IFITM3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of IFITM3 mRNA24935251|2718838
D014635Valproic AcidValproic Acid results in increased methylation of IFITM3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IFITM3 mRNA24896083
D014640VancomycinVancomycin results in decreased expression of IFITM3 mRNA18930951
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of IFITM3 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of IFITM3 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IFITM3 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IFITM3 gene25560391
C025643vinclozolinvinclozolin affects the expression of IFITM3 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of IFITM3 mRNA23034163
D014810Vitamin EVitamin E results in increased expression of IFITM3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18486613  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-TAS1906403  
GO:0009615response to virus-IDA20943977  21253575  22479637  
GO:0032897negative regulation of viral transcription-IDA20943977  
GO:0034341response to interferon-gamma-IBA21873635  
GO:0034341response to interferon-gamma-IDA21253575  
GO:0035455response to interferon-alpha-IBA21873635  
GO:0035455response to interferon-alpha-IDA22479637  
GO:0035456response to interferon-beta-IBA21873635  
GO:0035456response to interferon-beta-IDA21253575  
GO:0045071negative regulation of viral genome replication-IBA21873635  
GO:0045071negative regulation of viral genome replication-IDA20943977  21253575  
GO:0046597negative regulation of viral entry into host cell-IBA21873635  
GO:0046597negative regulation of viral entry into host cell-IDA20943977  21253575  
GO:0046597negative regulation of viral entry into host cell-IMP23358889  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IDA21478870  
GO:0060337type I interferon signaling pathway-IBA21873635  
GO:0060337type I interferon signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20943977  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031902late endosome membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147396Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)Cheong SCOral Oncol