Gene: YAP1

10413
COB1|YAP|YAP2|YAP65|YKI
Yes associated protein 1
protein-coding
11q22.1
Ensembl:ENSG00000137693 MIM:606608 Vega:OTTHUMG00000167322 UniprotKB:P46937
NG_029530.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.763e-1 (AD)  1.498e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FERMT20.934
LRP100.919
CDC14A0.914
PALLD0.911
PDLIM50.911
PLSCR40.908
ARHGAP310.907
TGFBR30.905
MAML20.904
CYBRD10.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.591
CALHM1-0.566
SLC7A4-0.562
PPEF1-0.559
ADTRP-0.558
AGMAT-0.555
GALNT14-0.555
CACNA1F-0.544
MYOZ3-0.542
ADRA1D-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of and affects the localization of YAP1 protein"21391223
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of YAP1 protein"21391223
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"YAP1 protein modified form results in increased susceptibility to 1,4-bis(2-(3,5-dichloropyridyloxy))benzene"21391223
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in decreased phosphorylation of and affects the localization of YAP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in decreased phosphorylation of and affects the localization of YAP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of YAP1 mRNA"20816883
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of YAP1 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of YAP1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of YAP1 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of YAP1 mRNA24449571
D001151ArsenicArsenic affects the localization of YAP1 protein23942117
D001151ArsenicArsenic results in increased expression of and results in decreased phosphorylation of YAP1 protein23942117
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of YAP1 mRNA"18687144
C487081belinostatbelinostat results in decreased expression of and results in decreased phosphorylation of YAP1 protein23671600
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of YAP1 mRNA20106945
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of YAP1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of YAP1 mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of YAP1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of YAP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of YAP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YAP1 mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of YAP1 protein28903499
D002220CarbamazepineCarbamazepine affects the expression of YAP1 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of YAP1 gene20938992
C031180chrysenechrysene results in increased expression of YAP1 mRNA26377693
D019327Copper SulfateCopper Sulfate results in increased expression of YAP1 mRNA19549813
D003471CuprizoneCuprizone affects the expression of YAP1 mRNA27523638
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of YAP1 mRNA19684285
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YAP1 mRNA28628672
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased phosphorylation of and affects the localization of YAP1 protein24146755
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of YAP1 mRNA17361019
D002945Cisplatin"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in decreased phosphorylation of and affects the localization of YAP1 protein"21214929
D002945Cisplatin[Cisplatin results in increased expression of MIR630] which results in decreased expression of YAP1 mRNA21274007
D002945CisplatinCisplatin results in increased expression of YAP1 protein modified form21214929
D002945Cisplatinwortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]21214929
D002945CisplatinYAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]20947521
D002945CisplatinYAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein]20947521
D002945Cisplatin"YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
D002945CisplatinYAP1 protein results in increased susceptibility to Cisplatin20729916
D002945CisplatinYAP1 results in decreased susceptibility to Cisplatin20947521
D004041Dietary FatsDietary Fats results in decreased expression of and results in decreased activity of YAP1 protein24147051
D004041Dietary Fats[Dietary Fats results in decreased expression of and results in decreased activity of YAP1 protein] which results in decreased expression of PENK protein alternative form24147051
D004041Dietary FatsDietary Fats results in decreased expression of YAP1 mRNA24147051
D004052Diethylnitrosamine"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of and affects the localization of YAP1 protein"21391223
D004317Doxorubicin"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in decreased phosphorylation of and affects the localization of YAP1 protein"21214929
D004317DoxorubicinDoxorubicin results in increased expression of YAP1 protein modified form21214929
D004317Doxorubicinwortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form]21214929
D004317Doxorubicin"YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of YAP1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of YAP1 gene20938992
D004397FonofosFonofos results in increased methylation of YAP1 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of YAP1 mRNA23649840
C039281furanfuran results in increased expression of YAP1 protein27371368
C056507gemcitabineSFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]26894857
C056507gemcitabineYAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]26894857
C056507gemcitabineYAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein]26894857
C056507gemcitabineYAP1 protein affects the susceptibility to gemcitabine26894857
C056507gemcitabineYAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]26894857
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of YAP1 mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of YAP1 mRNA28628672
C057531jasplakinolidejasplakinolide results in decreased phosphorylation of and affects the localization of YAP1 protein24040060
C057531jasplakinolideYAP1 protein affects the reaction [jasplakinolide results in increased expression of CTGF protein]24040060
C057531jasplakinolideYAP1 protein affects the reaction [jasplakinolide results in increased expression of CYR61 protein]24040060
D048628KetolidesKetolides analog results in decreased expression of YAP1 mRNA24967691
C008261lead acetatelead acetate affects the expression of YAP1 mRNA21864555
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of YAP1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of YAP1 mRNA28001369
C000621033napabucasinnapabucasin results in decreased expression of YAP1 mRNA25605917
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of YAP1 mRNA26272509
D010261ParaoxonParaoxon results in decreased expression of YAP1 mRNA24413757
D010278ParathionParathion results in increased methylation of YAP1 promoter22847954
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of YAP1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of YAP1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of YAP1 mRNA26272509
C513428pyrachlostrobinpyrachlostrobin results in increased expression of YAP1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of YAP1 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of YAP1 mRNA21427059
C017947sodium arsenitesodium arsenite results in increased expression of YAP1 mRNA28595984
C012568terbufosterbufos results in increased methylation of YAP1 promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of YAP1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of YAP1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of YAP1 mRNA21570461
D013806TheophyllineTheophylline results in decreased expression of YAP1 mRNA18951874
C009495titanium dioxidetitanium dioxide affects the expression of YAP1 mRNA17656681
D014241TrichloroethyleneTrichloroethylene results in decreased expression of YAP1 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of YAP1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of YAP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of YAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of YAP1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of YAP1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of YAP1 mRNA20546886|2142705
C551177vemurafenibvemurafenib affects the localization of YAP1 protein26668268
C551177vemurafenibYAP1 protein mutant form results in decreased susceptibility to vemurafenib26668268
C551177vemurafenib[YAP1 protein mutant form results in decreased susceptibility to vemurafenib] inhibits the reaction [vemurafenib results in decreased expression of MYC protein]26668268
C551177vemurafenib[YAP1 protein mutant form results in decreased susceptibility to vemurafenib] inhibits the reaction [vemurafenib results in decreased phosphorylation of MAPK1 protein]26668268
C551177vemurafenib[YAP1 protein mutant form results in decreased susceptibility to vemurafenib] inhibits the reaction [vemurafenib results in decreased phosphorylation of MAPK3 protein]26668268
C009687wortmanninwortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]21214929
C009687wortmanninwortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form]21214929
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of YAP1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0003713transcription coactivator activity-IDA18158288  18280240  20368466  25796446  
GO:0003713transcription coactivator activity-IMP20123905  
GO:0003714transcription corepressor activity-IDA18158288  
GO:0005515protein binding-IPI7644498  9202023  9305852  10562288  11278422  11278685  
12535517  15161933  15324660  16166090  17353931  17502622  
17974916  18158288  18280240  18579750  19439659  19914168  
20048001  20368466  21187284  21376238  22234184  22525271  
22863277  22921829  22948661  23245941  24211253  24255178  
24366813  24525233  24581491  24882516  24976009  25180228  
25283809  25670079  25751139  25751140  25796446  26258633  
26592798  27173435  28468127  
GO:0008022protein C-terminus binding-IEA-  
GO:0033613activating transcription factor binding-IPI20123905  20368466  
GO:0044212transcription regulatory region DNA binding-IDA18280240  
GO:0046982protein heterodimerization activity-IPI20123905  20368466  
GO:0070064proline-rich region binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IEA-  
GO:0001570vasculogenesis-IEA-  
GO:0001894tissue homeostasis-IEA-  
GO:0003015heart process-IEA-  
GO:0003143embryonic heart tube morphogenesis-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006974cellular response to DNA damage stimulus-IDA18280240  
GO:0008283cell proliferation-IDA17974916  
GO:0010837regulation of keratinocyte proliferation-IEA-  
GO:0030216keratinocyte differentiation-IEA-  
GO:0030857negative regulation of epithelial cell differentiation-IEA-  
GO:0030903notochord development-IEA-  
GO:0032570response to progesterone-IDA16772533  
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IDA16772533  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035329hippo signaling-TAS18158288  
GO:0045893positive regulation of transcription, DNA-templated-IDA20368466  
GO:0045893positive regulation of transcription, DNA-templated-IMP20123905  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA25796446  
GO:0048339paraxial mesoderm development-IEA-  
GO:0048368lateral mesoderm development-IEA-  
GO:0050767regulation of neurogenesis-IDA25433207  
GO:0050847progesterone receptor signaling pathway-IDA16772533  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060242contact inhibition-IDA17974916  
GO:0060449bud elongation involved in lung branching-IEA-  
GO:0060487lung epithelial cell differentiation-IEA-  
GO:0061026cardiac muscle tissue regeneration-IEA-  
GO:0065003protein-containing complex assembly-IDA20368466  
GO:0065003protein-containing complex assembly-IMP20123905  
GO:0071300cellular response to retinoic acid-IEA-  
GO:0071480cellular response to gamma radiation-IDA18280240  
GO:0072091regulation of stem cell proliferation-IDA25433207  
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:1902036regulation of hematopoietic stem cell differentiation-TAS-  
GO:1902459positive regulation of stem cell population maintenance-IEA-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:2000737negative regulation of stem cell differentiation-IEA-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17974916  18158288  18280240  25796446  28169360  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA17974916  18158288  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
GO:0071148TEAD-1-YAP complex-IDA20123905  
GO:0071149TEAD-2-YAP complex-IDA20368466  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1251985Nuclear signaling by ERBB4TAS
R-HSA-162582Signal TransductionTAS
R-HSA-2028269Signaling by HippoTAS
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-8940973RUNX2 regulates osteoblast differentiationIEA
R-HSA-8941326RUNX2 regulates bone developmentIEA
R-HSA-8951671RUNX3 regulates YAP1-mediated transcriptionTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26056182R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. (2015 Jul 10)Chen HYJ Clin Oncol
24621512Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). (2014)Zhao YPLoS One
25754111YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. (2015 Jun)Bora-Singhal NStem Cells
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology