Gene: TESK2

10420
-
testis associated actin remodelling kinase 2
protein-coding
1p34.1
Ensembl:ENSG00000070759 MIM:604746 Vega:OTTHUMG00000007680 UniprotKB:Q96S53
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.602e-1 (AD)  3.812e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTYH20.853
COL4A50.844
PHLDB10.841
SEMA6A0.836
TMTC20.833
HSPA20.826
FNBP10.824
SHC40.822
ZBED30.818
CREB50.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPYS-0.342
PRTN3-0.326
KLK5-0.324
GPR153-0.313
TCERG1L-0.304
PNOC-0.303
KCNK3-0.301
HCN4-0.301
TWIST2-0.3
OR4F29-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TESK2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of TESK2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TESK2 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TESK2 mRNA16483693
D001151ArsenicArsenic affects the expression of TESK2 mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TESK2 mRNA22316170
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TESK2 mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of TESK2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased methylation of TESK2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of TESK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TESK2 gene28505145
D004390ChlorpyrifosChlorpyrifos results in increased expression of TESK2 mRNA20691718
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TESK2 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of TESK2 mRNA23811191
D016572CyclosporineCyclosporine results in decreased expression of TESK2 mRNA19770486
D004026DieldrinDieldrin results in increased expression of TESK2 mRNA28385952
D004041Dietary FatsDietary Fats results in increased expression of TESK2 mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TESK2 mRNA20938992
D017313FenretinideFenretinide results in decreased expression of TESK2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of TESK2 mRNA28973697
C051890irinotecanirinotecan affects the expression of TESK2 mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TESK2 mRNA22904298|2479639
C045463leflunomideleflunomide results in decreased expression of TESK2 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TESK2 mRNA20938992
C025589ochratoxin Aochratoxin A results in increased expression of TESK2 mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TESK2 mRNA25729387
D010634PhenobarbitalPhenobarbital results in increased expression of TESK2 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TESK2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TESK2 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TESK2 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of TESK2 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TESK2 mRNA19770486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TESK2 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of TESK2 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TESK2 mRNA"26743178
D014520UrethaneUrethane results in increased expression of TESK2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TESK2 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS10512679  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0004712protein serine/threonine/tyrosine kinase activity-IEA-  
GO:0004713protein tyrosine kinase activity-IEA-  
GO:0005515protein binding-IPI22939624  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0048041focal adhesion assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci