Gene: CD52

1043
CDW52|EDDM5
CD52 molecule
protein-coding
1p36.11
Ensembl:ENSG00000169442 MIM:114280 Vega:OTTHUMG00000003491 UniprotKB:P31358
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
5.242e-2 (AD)  5.215e-1 (ND)   (Frontal_Cortex)
1.436e-2 (AD)  5.627e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH40.612
LMO10.582
ISLR0.538
FOXO60.529
HS3ST20.525
OLFML2B0.521
THOC60.52
GALNT140.518
GRIK30.511
KCNK20.506

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP4F11-0.362
ACBD7-0.355
RNF43-0.352
PCDHGA2-0.346
FREM2-0.339
MRO-0.332
PCDHGA3-0.331
BMPR1B-0.329
RAPSN-0.328
SSPN-0.321

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00087AlemtuzumabBiotechDrug216503-57-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CD52 mRNA"24680724
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CD52 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CD52 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of CD52 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD52 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD52 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CD52 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD52 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of CD52 mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of CD52 mRNA10673743|1576101
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of CD52 mRNA15894607
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD52 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CD52 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CD52 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CD52 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD52 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD52 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CD52 mRNA19693291
C006780bisphenol Abisphenol A results in increased expression of CD52 mRNA24586524
C006780bisphenol Abisphenol A affects the methylation of CD52 promoter27415467
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CD52 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CD52 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD52 mRNA27339419
D002509CephaloridineCephaloridine results in decreased expression of CD52 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CD52 mRNA23650126
D002737ChloropreneChloroprene results in decreased expression of CD52 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD52 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of CD52 mRNA18353800
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CD52 mRNA26033743
D003300CopperCopper deficiency results in increased expression of CD52 mRNA26033743
C014347decitabinedecitabine affects the expression of CD52 mRNA23300844
D003907DexamethasoneDexamethasone results in increased expression of CD52 mRNA21041162
D016264Dextran SulfateDextran Sulfate results in increased expression of CD52 mRNA23894361
D002945CisplatinCisplatin affects the expression of CD52 mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of CD52 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CD52 mRNA22609946
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CD52 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CD52 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD52 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD52 mRNA21041162
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD52 mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CD52 mRNA"19480007
C118739entinostatentinostat results in increased expression of CD52 mRNA27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of CD52 promoter27415467
D005472FluorouracilFluorouracil affects the expression of CD52 mRNA16584549
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CD52 mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD52 mRNA20938992
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of CD52 mRNA20846436
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CD52 mRNA15159207
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of CD52 mRNA26941288
D017313FenretinideFenretinide results in increased expression of CD52 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CD52 mRNA15761015
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD52 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD52 mRNA26941288
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD52 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD52 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CD52 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD52 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD52 mRNA"25554681
D009532NickelNickel results in increased expression of CD52 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of CD52 mRNA19167457
D010126OzoneOzone results in decreased expression of CD52 mRNA17095637
D000073878Palm OilPalm Oil results in decreased expression of CD52 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CD52 mRNA26272509
D010396PenicillaminePenicillamine results in decreased expression of CD52 mRNA19575532
C046012pentanalpentanal results in increased expression of CD52 mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of CD52 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of CD52 mRNA17426115
D059808PolyphenolsPolyphenols results in decreased expression of CD52 mRNA16293270
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CD52 mRNA19693291
C005556propionaldehydepropionaldehyde results in increased expression of CD52 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CD52 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CD52 mRNA16079270
D015474IsotretinoinIsotretinoin results in increased expression of CD52 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CD52 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of CD52 mRNA23221170
D012906SmokeSmoke affects the expression of CD52 mRNA23693141
D018038Sodium SeleniteSodium Selenite results in increased expression of CD52 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of CD52 mRNA20937368
D013739TestosteroneTestosterone results in decreased expression of CD52 mRNA19693291
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CD52 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD52 mRNA24680724|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD52 mRNA17337447
C009495titanium dioxidetitanium dioxide results in increased expression of CD52 mRNA23557971
D019772TopotecanTopotecan results in decreased expression of CD52 mRNA25729387
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of CD52 mRNA15894607
D014212TretinoinTretinoin results in increased expression of CD52 mRNA10673743|1239339
D014212TretinoinTretinoin results in increased expression of CD52 protein12393392
D014635Valproic AcidValproic Acid results in increased expression of CD52 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of CD52 gene29154799
D014640VancomycinVancomycin results in decreased expression of CD52 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of CD52 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD52 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CD52 mRNA26941288

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA8223854  
GO:0045730respiratory burst-NAS8223854  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS1711975  
GO:0031225anchored component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-TAS1711975  
GO:0097225sperm midpiece-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18540352[Update on the etiology and pathogenesis of multiple sclerosis and neuromyelitis optica]. (2008 Jun)Fujihara KNihon Rinsho