Gene: ACAA2

10449
DSAEC
acetyl-CoA acyltransferase 2
protein-coding
18q21.1
Ensembl:ENSG00000167315 MIM:604770 Vega:OTTHUMG00000132667 UniprotKB:P42765
NC_000018.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.236e-1 (AD)  8.943e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PON20.934
HADHB0.931
HSDL20.928
ALDH7A10.918
DECR10.91
BDH20.907
SLC25A200.903
TP53BP20.894
RAB310.893
ALDH6A10.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL12RB2-0.527
OSBPL10-0.525
KCNH1-0.515
GABRG3-0.514
COL19A1-0.514
PROKR2-0.513
AGMAT-0.512
KCNH5-0.512
TYRP1-0.51
CACNA1F-0.507

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole results in increased expression of ACAA2 mRNA"27665778
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACAA2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ACAA2 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACAA2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ACAA2 mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ACAA2 mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of ACAA2 protein24140754
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of ACAA2 mRNA14610520
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ACAA2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ACAA2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of ACAA2 protein11752693
D000082AcetaminophenAcetaminophen results in increased expression of ACAA2 protein21329376
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ACAA2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACAA2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACAA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACAA2 mRNA19770486
C430898AGN 194204AGN 194204 results in increased expression of ACAA2 mRNA16339527
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ACAA2 mRNA"23195993
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA16940010
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACAA2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of ACAA2 mRNA15761015
D001280AtrazineAtrazine results in decreased expression of ACAA2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACAA2 mRNA16269432
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ACAA2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACAA2 mRNA22228805|2719552
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACAA2 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACAA2 mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of ACAA2 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ACAA2 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ACAA2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ACAA2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ACAA2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ACAA2 mRNA26496021
C423844BL 11282BL 11282 results in increased expression of ACAA2 protein17458497
D002065BuspironeBuspirone results in increased expression of ACAA2 mRNA24136188
D002104CadmiumCadmium results in increased expression of ACAA2 mRNA23256528
D002104CadmiumCadmium results in increased oxidation of ACAA2 protein24496640
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACAA2 mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ACAA2 protein24527689
D019256Cadmium ChlorideCadmium Chloride affects the expression of ACAA2 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACAA2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ACAA2 mRNA15963342
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of ACAA2 mRNA16197558
C019304ciprofibrateciprofibrate results in increased expression of ACAA2 mRNA27225895
D002994ClofibrateClofibrate results in increased expression of ACAA2 mRNA19952500
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ACAA2 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ACAA2 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ACAA2 protein21338618
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACAA2 mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of ACAA2 mRNA12011481|1867016
D002994ClofibrateClofibrate results in increased expression of ACAA2 protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of ACAA2 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACAA2 mRNA24386269
D003300CopperCopper results in decreased expression of ACAA2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ACAA2 mRNA19549813
C030123coumarincoumarin affects the expression of ACAA2 mRNA16963487
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ACAA2 mRNA"19167446
D003471CuprizoneCuprizone results in increased expression of ACAA2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ACAA2 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of ACAA2 mRNA23830897
D016572CyclosporineCyclosporine results in increased expression of ACAA2 mRNA19770486
C093628cyproconazolecyproconazole results in decreased expression of ACAA2 mRNA22334560
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ACAA2 mRNA23640034
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACAA2 mRNA23428407
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACAA2 mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ACAA2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACAA2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ACAA2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ACAA2 mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of ACAA2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ACAA2 mRNA22672789
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA14656948
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ACAA2 mRNA25242112
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ACAA2 mRNA"22485181
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA25055962
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACAA2 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ACAA2 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ACAA2 protein26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ACAA2 mRNA28865727
C109476epoxiconazoleepoxiconazole results in decreased expression of ACAA2 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACAA2 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACAA2 mRNA17108234
D011345FenofibrateFenofibrate results in increased expression of ACAA2 mRNA25572481
D011345FenofibrateFenofibrate affects the expression of ACAA2 mRNA20801182
D011345FenofibrateFenofibrate results in increased expression of ACAA2 mRNA27665778
D011345FenofibrateFenofibrate results in increased expression of ACAA2 protein20118634
D018120FinasterideFinasteride results in increased expression of ACAA2 mRNA24136188
C043562flavoneflavone results in increased expression of ACAA2 protein14750173
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA14656948
D005485FlutamideFlutamide results in decreased expression of ACAA2 mRNA19442681
D005485FlutamideFlutamide results in decreased expression of ACAA2 mRNA24793618
D005485FlutamideFlutamide results in increased expression of ACAA2 mRNA21525395|2413618
C039281furanfuran binds to ACAA2 protein22240984
D015248GemfibrozilGemfibrozil affects the expression of ACAA2 mRNA12011481|2766577
D019833GenisteinGenistein results in decreased expression of ACAA2 mRNA22228119
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACAA2 mRNA23428407
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ACAA2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ACAA2 mRNA23086925
C410337K 7174K 7174 results in decreased expression of ACAA2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of ACAA2 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ACAA2 mRNA25613284
D008727MethotrexateMethotrexate results in increased expression of ACAA2 mRNA17400583
D008727MethotrexateMethotrexate affects the expression of ACAA2 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACAA2 mRNA23458150
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA]"20230807
C500085muraglitazarmuraglitazar results in increased expression of ACAA2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACAA2 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of ACAA2 mRNA24136188
D009532NickelNickel results in decreased expression of ACAA2 mRNA23195993
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA"20230807
D009538Nicotine"Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA]"20230807
C012655nimesulidenimesulide results in increased expression of ACAA2 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ACAA2 mRNA17616710
C025256nonylphenolnonylphenol results in decreased expression of ACAA2 mRNA22982499
C464660obeticholic acidobeticholic acid results in increased expression of ACAA2 mRNA27939613
D010100OxygenOxygen deficiency results in decreased expression of ACAA2 mRNA19695866
D000073878Palm OilPalm Oil results in increased expression of ACAA2 mRNA18042831
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ACAA2 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ACAA2 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACAA2 mRNA18692542|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACAA2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACAA2 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ACAA2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ACAA2 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACAA2 mRNA19162173|2851185
C031181phenanthrenephenanthrene results in increased expression of ACAA2 mRNA19457238
D010634PhenobarbitalPhenobarbital results in decreased expression of ACAA2 mRNA19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of ACAA2 mRNA12011481|1916217
D010695PhlorhizinPhlorhizin results in decreased expression of ACAA2 mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of ACAA2 mRNA16221962|1742611
C006253pirinixic acidpirinixic acid results in increased expression of ACAA2 mRNA12011481|1694001
D017035PravastatinPravastatin results in decreased expression of ACAA2 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of ACAA2 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ACAA2 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of ACAA2 mRNA21278054|2233456
C010313pseudocumenepseudocumene results in decreased expression of ACAA2 protein17337753
D011794QuercetinQuercetin results in decreased expression of ACAA2 mRNA21632981
C059514resveratrolresveratrol results in increased expression of ACAA2 protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of ACAA2 mRNA20436886
C488333Ro 65-7199Ro 65-7199 affects the expression of ACAA2 mRNA14610520
C089730rosiglitazonerosiglitazone affects the expression of ACAA2 mRNA22013433
C089730rosiglitazonerosiglitazone affects the expression of ACAA2 protein21347706
C089730rosiglitazonerosiglitazone results in increased expression of ACAA2 mRNA17245590
C089730rosiglitazonerosiglitazone results in increased expression of ACAA2 mRNA21515302
D012524SarinSarin results in decreased expression of ACAA2 mRNA19522546
D012643SeleniumSelenium results in increased expression of ACAA2 mRNA19244175
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA25055962
D019821SimvastatinSimvastatin results in decreased expression of ACAA2 mRNA25055962
C009277sodium arsenatesodium arsenate results in increased expression of ACAA2 mRNA23922661
D012969Sodium FluorideSodium Fluoride results in decreased expression of ACAA2 protein27548804
D018038Sodium SeleniteSodium Selenite results in increased expression of ACAA2 mRNA18175754
C075117squalestatin 1squalestatin 1 affects the expression of ACAA2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of ACAA2 mRNA27225895
D010042OuabainOuabain affects the expression of ACAA2 protein17268060
C501413tesaglitazartesaglitazar results in increased expression of ACAA2 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ACAA2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACAA2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACAA2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACAA2 mRNA11906171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACAA2 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACAA2 mRNA26232522
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ACAA2 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of ACAA2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACAA2 protein22609517
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ACAA2 protein22595367
D014212TretinoinTretinoin results in decreased expression of ACAA2 mRNA16788091
C011559tributyltintributyltin results in increased expression of ACAA2 mRNA23428407
C012589trichostatin Atrichostatin A results in increased expression of ACAA2 mRNA15901671
D014303TrinitrotolueneTrinitrotoluene affects the expression of ACAA2 mRNA21346803
C057693troglitazonetroglitazone results in increased expression of ACAA2 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of ACAA2 mRNA17127020
D014520UrethaneUrethane results in decreased expression of ACAA2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of ACAA2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ACAA2 mRNA15901671
D014640VancomycinVancomycin results in increased expression of ACAA2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACAA2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ACAA2 mRNA22615374
D014810Vitamin EVitamin E results in increased expression of ACAA2 mRNA19244175
D015032ZincZinc deficiency results in decreased expression of ACAA2 mRNA12672911|1567121
D015032ZincZinc deficiency results in decreased expression of ACAA2 protein15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003988acetyl-CoA C-acyltransferase activity-IBA21873635  
GO:0003988acetyl-CoA C-acyltransferase activity-NAS8241273  
GO:0003988acetyl-CoA C-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI18371312  
GO ID GO Term Qualifier Evidence PubMed
GO:0006635fatty acid beta-oxidation-IBA21873635  
GO:0006635fatty acid beta-oxidation-TAS-  
GO:0006695cholesterol biosynthetic process-NAS8241273  
GO:0071456cellular response to hypoxia-IDA18371312  
GO:1901029negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway-IDA18371312  
GO:1902109negative regulation of mitochondrial membrane permeability involved in apoptotic process-IDA18371312  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA18371312  
GO:0005739mitochondrion-NAS8241273  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00062Fatty acid elongation
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28550509Possible involvement of ACSS2 gene in alcoholism. (2017 Sep)Ribeiro AFJ Neural Transm (Vienna)