Gene: CDX2

1045
CDX-3|CDX2/AS|CDX3
caudal type homeobox 2
protein-coding
13q12.2
Ensembl:ENSG00000165556 MIM:600297 Vega:OTTHUMG00000016640 UniprotKB:Q99626
NC_000013.11
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.320e-2 (AD)  8.880e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCAF8L20.591
ZG160.522
HTN30.519
OR5M110.512
OR52N10.512
UGT2A30.511
OR10G30.503
LINC004300.499
OR10J30.497
CDX40.496

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM180B-0.284
INHA-0.277
SOX3-0.274
ZNF98-0.272
ACOT6-0.264
ACOT1-0.264
HSD17B8-0.263
HPDL-0.262
PBLD-0.259
MPV17L-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]15350541
C0259463-methyladenine3-methyladenine results in increased expression of CDX2 mRNA21681844
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the expression of CDX2 mRNA"25670856
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]"27783115
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of CDX2 mRNA"27783115
C1118556-formylindolo(3,2-b)carbazole"[Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA"27783115
C1118556-formylindolo(3,2-b)carbazole"[Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA"27783115
D019342Acetic AcidAcetic Acid affects the expression of CDX2 protein21296659
D000143AcidsAcids results in decreased methylation of CDX2 mRNA16990345
D000143Acids[Acids results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNA16990345
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDX2 mRNA18164116
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of CDX2 protein21127259
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of CDX2 mRNA25973022
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 mRNA]28780155
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 protein]28780155
C006780bisphenol Abisphenol A results in decreased expression of CDX2 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of CDX2 protein21296659
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of CDX2 mRNA20818264
D002793Cholic AcidsCholic Acids results in decreased methylation of CDX2 mRNA16990345
D002793Cholic Acids[Cholic Acids results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNA16990345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDX2 gene20938992
C551788CL 075"6-formylindolo(3,2-b)carbazole promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]"27783115
C551788CL 075CL 075 results in increased expression of CDX2 mRNA27783115
C551788CL 075indole-3-carbinol promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]27783115
C551788CL 075Tetrachlorodibenzodioxin promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]27783115
D003474CurcuminCurcumin results in increased expression of CDX2 mRNA27237783
D003474CurcuminCurcumin results in increased expression of CDX2 mRNA18299980
C014347decitabine[decitabine co-treated with CDX2 protein] results in increased expression of KRT20 mRNA18845559
C014347decitabine[decitabine co-treated with CDX2 protein] results in increased expression of RETNLB mRNA18845559
C014347decitabine[decitabine co-treated with CDX2 protein] results in increased expression of SLC26A3 mRNA18845559
C014347decitabine[decitabine co-treated with CDX2 protein] results in increased expression of SLC9A2 mRNA18845559
C014347decitabine[decitabine results in decreased methylation of CDX2 mRNA] which results in increased expression of CDX2 mRNA16990345
C014347decitabinedecitabine results in decreased methylation of CDX2 promoter16990345
C014347decitabinedecitabine results in increased expression of CDX2 mRNA16990345|1884555
C014347decitabineMethyl Methanesulfonate inhibits the reaction [decitabine results in increased expression of CDX2 mRNA]16990345
C014347decitabinetrichostatin A promotes the reaction [decitabine results in increased expression of CDX2 mRNA]16990345
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CDX2 mRNA28286118
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDX2 mRNA18164116
D005419FlavonoidsFlavonoids results in increased expression of CDX2 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of CDX2 protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDX2 gene20938992
C039281furanfuran results in increased expression of CDX2 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDX2 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]27783115
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDX2 mRNA26752646
D008070LipopolysaccharidesCDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D008070Lipopolysaccharides"[Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA"27783115
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA27783115
D008070LipopolysaccharidesCDX2 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]21131441
D008070LipopolysaccharidesCDX2 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]21131441
D008070LipopolysaccharidesCDX2 protein results in increased susceptibility to Lipopolysaccharides21131441
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDX2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CDX2 mRNA20864626
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CDX2 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CDX2 mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate inhibits the reaction [decitabine results in increased expression of CDX2 mRNA]16990345
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDX2 mRNA16990345
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the localization of CDX2 protein27037955
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDX2 mRNA27037955
D052638Particulate MatterParticulate Matter results in decreased expression of CDX2 protein20525899
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDX2 mRNA18692542
D010672PhenytoinPhenytoin results in increased expression of CDX2 mRNA20345932
D011070Poly I-C"[Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA"27783115
D011070Poly I-C[Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA27783115
C034912puag-haadbisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 mRNA]28780155
C034912puag-haadbisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of CDX2 protein]28780155
C034912puag-haadpuag-haad results in increased expression of CDX2 mRNA28780155
C034912puag-haadpuag-haad results in increased expression of CDX2 protein28780155
C009166retinol acetateretinol acetate results in increased expression of CDX2 mRNA16772331
D020123SirolimusSirolimus results in increased expression of CDX2 mRNA21681844
D013749TetrachlorodibenzodioxinCDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D013749Tetrachlorodibenzodioxin[Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA27783115
D013749Tetrachlorodibenzodioxin[Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [CL 075 results in increased expression of CDX2 mRNA]27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDX2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDX2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDX2 mRNA20558275
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDX2 mRNA27237783
C012589trichostatin Atrichostatin A promotes the reaction [decitabine results in increased expression of CDX2 mRNA]16990345
D014635Valproic AcidValproic Acid results in increased methylation of CDX2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CDX2 mRNA27237783|2769348
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CDX2 protein20525899
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDX2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA15677472  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA15677472  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS9459001  
GO:0003714transcription corepressor activity-IEA-  
GO:0008327methyl-CpG binding-IDA28473536  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15677472  
GO:0001568blood vessel development-IEA-  
GO:0001829trophectodermal cell differentiation-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9459001  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008333endosome to lysosome transport-IEA-  
GO:0009887animal organ morphogenesis-IBA21873635  
GO:0009887animal organ morphogenesis-TAS9052785  
GO:0009948anterior/posterior axis specification-IBA21873635  
GO:0014807regulation of somitogenesis-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IEA-  
GO:0045597positive regulation of cell differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0060575intestinal epithelial cell differentiation-ISS-  
GO:0060711labyrinthine layer development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0017053transcriptional repressor complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28411367Serum 25(OH)D concentration, common variants of the VDR gene and lung cancer occurrence. (2017 Jul 15)Gromowski TInt J Cancer
26677401MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma-a step towards personalized therapy. (2015)Garajova IClin Epigenetics
22221671Squamous cell carcinoma in Barrett's esophagus: field effect versus metastasis. (2012 Sep-Oct)Streppel MMDis Esophagus
24342438Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms. (2014 Feb)Elias KMGynecol Oncol
27258560The Role of SATB2 as a Diagnostic Marker of Sinonasal Intestinal-type Adenocarcinoma. (2018 Feb)Skalova AAppl Immunohistochem Mol Morphol
23887294KRAS mutational analysis and immunohistochemical studies can help distinguish pancreatic metastases from primary lung adenocarcinomas. (2014 Feb)Krasinskas AMMod Pathol
19667145The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. (2009 Sep)Kostner KAnticancer Res
22242137Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. (2011)Hama TPLoS One