Gene: PPIE

10450
CYP-33|CYP33
peptidylprolyl isomerase E
protein-coding
1p34.2
Ensembl:ENSG00000084072 MIM:602435 Vega:OTTHUMG00000009248 UniprotKB:Q9UNP9
NG_044984.2
PubMed
0   ANCO-SNPs
ND
1   
9.819e-1 (AD)  9.358e-1 (ND)   (Frontal_Cortex)
3.037e-1 (AD)  1.115e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNRNP400.873
DAP30.87
TAF110.869
PSMC20.868
NGDN0.868
PA2G40.867
EIF2B10.864
CPSF30.862
PSMA60.861
MRPL220.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.612
OR4F29-0.581
MTRNR2L6-0.353
MTRNR2L9-0.338
TTLL10-0.312
MTRNR2L10-0.299
RNF223-0.284
MTRNR2L2-0.266
OR4F16-0.262
P2RY14-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA"27188386
D001280AtrazineAtrazine results in increased expression of PPIE mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PPIE mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPIE mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of PPIE mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPIE mRNA19376846
D002945CisplatinCisplatin results in increased expression of PPIE protein16803524
D004147DioxinsDioxins affects the expression of PPIE mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PPIE mRNA29097150
D005472FluorouracilFluorouracil results in increased expression of PPIE protein16803524
D005485FlutamideFlutamide results in increased expression of PPIE mRNA24136188
D006418HemeHeme metabolite results in increased expression of PPIE mRNA19191707
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of PPIE mRNA24680724
D008345ManganeseManganese results in decreased expression of PPIE mRNA18284614
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPIE mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PPIE mRNA"20188158
C051752nefazodonenefazodone results in increased expression of PPIE mRNA24136188
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PPIE protein19954255
D053260SootSoot results in increased expression of PPIE mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPIE mRNA21570461|2468072
D013853ThioacetamideThioacetamide results in increased expression of PPIE mRNA23411599
D014415TunicamycinTunicamycin results in increased expression of PPIE mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPIE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PPIE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PPIE mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003723RNA binding-TAS11313484  
GO:0003729mRNA binding-IDA18258190  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IBA21873635  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IDA18258190  20676357  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-TAS11313484  
GO:0005515protein binding-IPI11313484  16189514  20541251  22365833  25416956  25599396  
GO:0008143poly(A) binding-IDA18258190  
GO:0016018cyclosporin A binding-IDA20676357  
GO:0051082unfolded protein binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA28076346  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0000413protein peptidyl-prolyl isomerization-IDA20676357  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006355regulation of transcription, DNA-templated-IMP11313484  
GO:0006457protein folding-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045070positive regulation of viral genome replication-IBA21873635  
GO:0045070positive regulation of viral genome replication-IMP19932913  
GO ID GO Term Qualifier Evidence PubMed
GO:0000974Prp19 complex-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IDA11313484  28076346  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA-  
GO:0034774secretory granule lumen-TAS-  
GO:0071007U2-type catalytic step 2 spliceosome-IDA28076346  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73894DNA RepairTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27903268Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). (2016 Dec 1)Chi GCEnviron Health