Gene info: ID 10451

Gene: VAV3

GENE ID: 10451

Synonyms: -

Description: vav guanine nucleotide exchange factor 3

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000134215 MIM:605541 Vega:OTTHUMG00000010995 UniprotKB:Q9UKW4

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.034e-1 (AD) 7.590e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPP1R3D	0.678
FGD6	0.669
SLC4A4	0.663
GABRA2	0.654
AK4	0.653
ELOVL2	0.649
SLC15A2	0.647
AHCYL2	0.645
SLC1A3	0.644
MSI2	0.637

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM139	-0.329
ANXA13	-0.328
OR4F5	-0.324
ARHGAP22	-0.312
DYNAP	-0.304
BTBD16	-0.298
CHRM5	-0.297
HMSD	-0.296
PTPRH	-0.289
FAM178B	-0.283

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of VAV3 mRNA"	20453058
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of VAV3 mRNA	19933214
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in increased expression of VAV3 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of VAV3 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of VAV3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of VAV3 mRNA	23630614
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of VAV3 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of VAV3 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of VAV3 mRNA	20458559
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of VAV3 mRNA"	18687144\|2535159
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of VAV3 mRNA	21635667
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of VAV3 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of VAV3 mRNA	21635667
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of VAV3 mRNA	26314263
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of VAV3 mRNA	20064835\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of VAV3 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of VAV3 mRNA	20713471
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of VAV3 mRNA"	26238291
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of VAV3 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of VAV3 mRNA	19619570
C006780	bisphenol A	bisphenol A affects the expression of VAV3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of VAV3 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of VAV3 mRNA	26314263
D001966	Bromine	Bromine results in decreased expression of VAV3 mRNA	18790026
C018475	butyraldehyde	butyraldehyde results in decreased expression of VAV3 mRNA	26079696
D002737	Chloroprene	Chloroprene results in increased expression of VAV3 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of VAV3 mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in increased expression of VAV3 mRNA	26314263
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of VAV3 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of VAV3 mRNA	21632981\|2556210
D013759	Dronabinol	Dronabinol results in increased expression of VAV3 mRNA	18454173
D002945	Cisplatin	VAV3 protein affects the susceptibility to Cisplatin	16217747
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in decreased expression of VAV3 mRNA	21852083
D002117	Calcitriol	Calcitriol results in decreased expression of VAV3 mRNA	16002434
D004237	Diuron	Diuron results in increased expression of VAV3 mRNA	21551480
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of VAV3 mRNA	26865667
C082360	fipronil	fipronil results in increased expression of VAV3 mRNA	23962444
D005472	Fluorouracil	Fluorouracil results in decreased expression of VAV3 mRNA	16557594
D019833	Genistein	Genistein results in decreased expression of VAV3 mRNA	26865667
C004312	glycidol	glycidol results in increased expression of VAV3 mRNA	24915197
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of VAV3 mRNA"	21635667
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAV3 mRNA	25613284
C045463	leflunomide	leflunomide results in decreased expression of VAV3 mRNA	28988120
C533894	LG 100815	LG 100815 results in decreased expression of VAV3 mRNA	16951191
D047311	Luteolin	Luteolin results in decreased expression of VAV3 mRNA	19397994
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of VAV3 mRNA	26378955
D008727	Methotrexate	Methotrexate results in decreased expression of VAV3 mRNA	17400583
D008727	Methotrexate	Methotrexate affects the expression of VAV3 mRNA	18502557
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of VAV3 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of VAV3 mRNA	28001369
C030957	methylmercury II	methylmercury II results in increased expression of VAV3 mRNA	26314263
D009151	Mustard Gas	Mustard Gas results in decreased expression of VAV3 mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of VAV3 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of VAV3 mRNA	25583101
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of VAV3 mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in increased expression of VAV3 mRNA	26314263
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of VAV3 mRNA"	16951191
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of VAV3 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of VAV3 mRNA	26516004
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of VAV3 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of VAV3 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of VAV3 mRNA	17426115
D010938	Plant Oils	Plant Oils results in decreased expression of VAV3 mRNA	23370395
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of VAV3 mRNA	24780913
C059514	resveratrol	resveratrol results in decreased expression of VAV3 mRNA	19371625
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in decreased expression of VAV3 mRNA	21852083
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of VAV3 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of VAV3 mRNA	25351596
D012834	Silver	Silver results in decreased expression of VAV3 mRNA	26014281
C009277	sodium arsenate	sodium arsenate results in increased expression of VAV3 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of VAV3 mRNA	24516582
C016104	sodium bichromate	sodium bichromate results in decreased expression of VAV3 mRNA	17685462
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of VAV3 mRNA	26378955
C061133	tamibarotene	tamibarotene results in decreased expression of VAV3 mRNA	17229644
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of VAV3 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of VAV3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VAV3 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VAV3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VAV3 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VAV3 mRNA	19933214
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAV3 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of VAV3 mRNA	25447457
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of VAV3 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of VAV3 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of VAV3 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of VAV3 mRNA	21934132\|2372400
C011559	tributyltin	tributyltin results in increased expression of VAV3 mRNA	26314263
C012589	trichostatin A	trichostatin A results in decreased expression of VAV3 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of VAV3 mRNA"	26179874
D014520	Urethane	Urethane results in decreased expression of VAV3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of VAV3 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of VAV3 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of VAV3 mRNA	23034163
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VAV3 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of VAV3 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005070	SH3/SH2 adaptor activity	-	TAS	10523675
GO:0005085	guanyl-nucleotide exchange factor activity	-	EXP	8990121
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005089	Rho guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005096	GTPase activator activity	-	TAS	10523675
GO:0005154	epidermal growth factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	12577067 16982329 18654987 20936779 21706016 24728074
GO:0030676	Rac guanyl-nucleotide exchange factor activity	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0006906	vesicle fusion	-	IEA	-
GO:0006974	cellular response to DNA damage stimulus	-	IMP	17875758
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007229	integrin-mediated signaling pathway	-	IEA	-
GO:0007264	small GTPase mediated signal transduction	-	IEA	-
GO:0008361	regulation of cell size	-	IGI	22467863
GO:0008361	regulation of cell size	NOT	IGI	22467863
GO:0009967	positive regulation of signal transduction	-	IEA	-
GO:0030032	lamellipodium assembly	-	IEA	-
GO:0030168	platelet activation	-	TAS	-
GO:0030593	neutrophil chemotaxis	-	IEA	-
GO:0030890	positive regulation of B cell proliferation	-	IMP	17875758
GO:0035023	regulation of Rho protein signal transduction	-	IEA	-
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0042493	response to drug	-	IMP	17875758
GO:0043065	positive regulation of apoptotic process	-	TAS	-
GO:0043087	regulation of GTPase activity	-	IGI	22467863
GO:0043547	positive regulation of GTPase activity	-	IEA	-
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	IEA	-
GO:0045785	positive regulation of cell adhesion	-	IEA	-
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	-
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0050853	B cell receptor signaling pathway	-	IMP	17875758
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04510	Focal adhesion
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04670	Leukocyte transendothelial migration
hsa04810	Regulation of actin cytoskeleton

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-109582	Hemostasis	IEA
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-114604	GPVI-mediated activation cascade	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-193648	NRAGE signals death through JNK	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194138	Signaling by VEGF	IEA
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194840	Rho GTPase cycle	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	TAS
R-HSA-2172127	DAP12 interactions	TAS
R-HSA-2424491	DAP12 signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2871796	FCERI mediated MAPK activation	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-2871809	FCERI mediated Ca+2 mobilization	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	IEA
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27430689	[Association between polymorphism in Vav3 genes and risk of primary prostatic cancer in Chinese Han population]. (2016 Jul 8)	Liu M	Zhonghua Bing Li Xue Za Zhi