Gene: TOMM40

10452
C19orf1|D19S1177E|PER-EC1|PEREC1|TOM40
translocase of outer mitochondrial membrane 40
protein-coding
19q13.32
Ensembl:ENSG00000130204 MIM:608061 Vega:OTTHUMG00000180842 UniprotKB:O96008
NG_042854.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.002e-1 (AD)  1.145e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIMM500.958
MRPL40.944
RUVBL20.937
FARSA0.934
POP70.932
CDIPT0.93
PSMG30.93
C6orf1360.93
TBRG40.929
MRPL280.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.673
OR4F29-0.613
MTRNR2L9-0.421
MTRNR2L6-0.4
VNN2-0.398
EBF1-0.382
CXCR2-0.381
IL18RAP-0.379
MTRNR2L10-0.372
FCGR3B-0.371

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of TOMM40 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TOMM40 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TOMM40 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of TOMM40 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of TOMM40 mRNA]21233418
D001151ArsenicArsenic affects the expression of TOMM40 mRNA18414638
D001280AtrazineAtrazine results in decreased expression of TOMM40 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of TOMM40 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TOMM40 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TOMM40 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TOMM40 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TOMM40 mRNA18804290
C100187chloropicrinchloropicrin results in decreased expression of TOMM40 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TOMM40 gene20938992
D003976DiazinonDiazinon results in increased methylation of TOMM40 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TOMM40 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TOMM40 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TOMM40 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TOMM40 mRNA27392435
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of TOMM40 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of TOMM40 mRNA21233418
D015025ZearalenoneZearalenone results in increased expression of TOMM40 protein25058043
D005485FlutamideFlutamide results in increased expression of TOMM40 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TOMM40 gene20938992
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of TOMM40 protein]20884965
D019833GenisteinGenistein results in decreased expression of TOMM40 protein20884965
D005897GlafenineGlafenine results in increased expression of TOMM40 mRNA24136188
D017313FenretinideFenretinide affects the expression of TOMM40 mRNA16570282
C428264indioside Dindioside D results in decreased expression of TOMM40 protein18376857
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TOMM40 mRNA27392435
C410337K 7174K 7174 results in decreased expression of TOMM40 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TOMM40 gene20938992
D008727MethotrexateMethotrexate results in increased expression of TOMM40 mRNA17400583
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TOMM40 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TOMM40 protein24806433
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TOMM40 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TOMM40 mRNA"25554681|2562005
C012655nimesulidenimesulide results in increased expression of TOMM40 mRNA24136188
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of TOMM40 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of TOMM40 mRNA]"21673326
D010100OxygenOxygen deficiency results in decreased expression of TOMM40 mRNA26516004
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TOMM40 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in decreased expression of TOMM40 mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TOMM40 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TOMM40 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of TOMM40 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of TOMM40 mRNA24677778
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TOMM40 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TOMM40 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of TOMM40 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of TOMM40 mRNA21278054
C089730rosiglitazonerosiglitazone affects the expression of TOMM40 mRNA22013433
D012402RotenoneRotenone results in decreased expression of TOMM40 protein24036476
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TOMM40 mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of TOMM40 mRNA25993096
D013311StreptozocinStreptozocin affects the expression of TOMM40 mRNA18583417
C066340tolcaponetolcapone binds to TOMM40 protein19783845
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TOMM40 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of TOMM40 mRNA21346803
D014520UrethaneUrethane results in decreased expression of TOMM40 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of TOMM40 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of TOMM40 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TOMM40 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TOMM40 gene25560391
D015032ZincZinc deficiency results in increased expression of TOMM40 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27554484  
GO:0008320protein transmembrane transporter activity-ISS-  
GO:0008320protein transmembrane transporter activity-TAS15644312  
GO:0015288porin activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006626protein targeting to mitochondrion-IMP15644312  
GO:0006811ion transport-IEA-  
GO:0030150protein import into mitochondrial matrix-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrionNOTIMP11745481  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005742mitochondrial outer membrane translocase complex-IBA21873635  
GO:0005742mitochondrial outer membrane translocase complex-IDA12198123  15644312  
GO:0005743mitochondrial inner membrane-IDA24746669  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IDA15644312  
GO:0031307integral component of mitochondrial outer membrane-ISS10980201  
GO:0046930pore complex-IEA-  
KEGG ID KEGG Term
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26171154Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. (2015 Jul)Yamase YBiomed Rep
27015805Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. (2016 Mar)Pilling LCAging (Albany NY)
20675872[Risk factors for Alzheimer's disease]. (2010 Jul)Ikeda TBrain Nerve