Gene info: ID 10454

Gene: TAB1

GENE ID: 10454

Synonyms: 3'-Tab1|MAP3K7IP1

Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 1

Gene type: protein-coding

Location: 22q13.1

dbXrefs: Ensembl:ENSG00000100324 MIM:602615 Vega:OTTHUMG00000151102 UniprotKB:Q15750

RefSeq: NG_029549.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.660e-1 (AD) 2.884e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TECPR2	0.91
VPS52	0.896
ATG2A	0.895
ARFGAP2	0.89
MAN1B1	0.889
SLC35C2	0.888
DCAF8	0.887
GPS1	0.886
SPPL2B	0.886
SPG7	0.886

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.685
OR4F29	-0.648
MTRNR2L6	-0.399
MTRNR2L9	-0.386
PABPC4L	-0.358
PPBP	-0.353
MTRNR2L10	-0.337
SIX1	-0.329
GSDMA	-0.319
SPRR4	-0.318

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06757	Manganese	Small Molecule	7439-96-5	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C003898	2-anisidine	2-anisidine results in decreased expression of TAB1 mRNA	28089782
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of TAB1 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen affects the expression of TAB1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of TAB1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TAB1 mRNA	19770486
C547126	AZM551248	AZM551248 results in decreased expression of TAB1 mRNA	22323515
C006780	bisphenol A	bisphenol A affects the expression of TAB1 mRNA	25181051
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of TAB1 mRNA	24921660
D003976	Diazinon	Diazinon results in increased methylation of TAB1 gene	22964155
C016366	dibenzothiophene	dibenzothiophene results in increased expression of TAB1 mRNA	23656968
D002945	Cisplatin	Cisplatin results in decreased phosphorylation of TAB1 protein	22006019
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of TAB1 mRNA	27638505
D004147	Dioxins	Dioxins affects the expression of TAB1 mRNA	20463971
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAB1 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of TAB1 mRNA	27392435
D008345	Manganese	Manganese binds to TAB1 protein	16879102
C013592	mangiferin	mangiferin results in decreased expression of TAB1 mRNA	15135318
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TAB1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TAB1 mRNA"	25554681
C464660	obeticholic acid	obeticholic acid results in decreased expression of TAB1 mRNA	27939613
D019821	Simvastatin	Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein]	17277159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TAB1 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TAB1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide affects the expression of TAB1 mRNA	17656681
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TAB1 mRNA"	19682533
D014520	Urethane	Urethane results in decreased expression of TAB1 mRNA	28818685

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004722	protein serine/threonine phosphatase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	10094049 11460167 11847341 14743216 16845370 17620599 19026643 19875381 21900206 21903422 21988832 22158122 25241761 25260751 27505673
GO:0008047	enzyme activator activity	-	TAS	8638164
GO:0019209	kinase activator activity	-	IEA	-
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0048273	mitogen-activated protein kinase p38 binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000185	activation of MAPKKK activity	-	IEA	-
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0003007	heart morphogenesis	-	IEA	-
GO:0003279	cardiac septum development	-	IEA	-
GO:0006470	protein dephosphorylation	-	IEA	-
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IEA	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007254	JNK cascade	-	TAS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0030324	lung development	-	IEA	-
GO:0035904	aorta development	-	IEA	-
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0060976	coronary vasculature development	-	IEA	-
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0010008	endosome membrane	-	TAS	-
GO:0016607	nuclear speck	-	IDA	-
GO:0032991	protein-containing complex	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26884850	Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. (2015)	Zhu J	Int J Clin Exp Pathol