Gene: HAX1

10456
HCLSBP1|HS1BP1|SCN3
HCLS1 associated protein X-1
protein-coding
1q21.3
Ensembl:ENSG00000143575 MIM:605998 Vega:OTTHUMG00000035978 UniprotKB:O00165
NG_007369.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.897e-1 (AD)  5.634e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3I0.959
COPZ10.956
SOD10.948
SUCLG10.946
PSMA70.943
STOML20.942
CHCHD10.942
PEF10.942
PSMB60.942
COPS60.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.813
OR4F29-0.774
KLRB1-0.29
KLRF1-0.272
FCRL1-0.27
KRT73-0.268
OR6C74-0.264
P2RY14-0.262
IL2RB-0.261
IL18RAP-0.26

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HAX1 mRNA"25614096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAX1 mRNA"28973690
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of HAX1 mRNA19679660
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HAX1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of HAX1 mRNA17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]19679660
C103505AM 251AM 251 results in increased expression of HAX1 mRNA16500647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HAX1 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HAX1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of HAX1 protein19763263
C044887beta-methylcholinebeta-methylcholine affects the expression of HAX1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of HAX1 mRNA28159858
D002220CarbamazepineCarbamazepine affects the expression of HAX1 mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of HAX1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of HAX1 mRNA20106945|2798913
D016190CarboplatinPravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein]18483861
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of HAX1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HAX1 mRNA17361019
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA15784690
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HAX1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAX1 mRNA17942748
D005839GentamicinsHMOX1 protein promotes the reaction [Gentamicins results in increased expression of HAX1 protein]18842672
D005839GentamicinsGentamicins results in increased expression of and results in increased localization of HAX1 protein18842672
C492448ICG 001ICG 001 results in increased expression of HAX1 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HAX1 mRNA23430699
C038753leptomycin Bleptomycin B affects the localization of HAX1 protein23164465
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HAX1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HAX1 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HAX1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HAX1 mRNA"25554681
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HAX1 mRNA"17622302
D016627OxidopamineOxidopamine results in increased expression of HAX1 protein19763263
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HAX1 protein26879310
C006253pirinixic acidpirinixic acid results in decreased expression of HAX1 mRNA18445702
D017035PravastatinPravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein]18483861
C059514resveratrolresveratrol results in increased expression of HAX1 mRNA22610192
D012402RotenoneRotenone affects the expression of HAX1 protein19763263
C009277sodium arsenatesodium arsenate results in decreased expression of HAX1 mRNA23922661
C017947sodium arseniteHAX1 protein affects the susceptibility to sodium arsenite23164465
C017947sodium arsenite[HAX1 protein affects the susceptibility to sodium arsenite] which affects the expression of POLB mRNA23164465
C017947sodium arsenitesodium arsenite affects the localization of HAX1 protein23164465
D018038Sodium SeleniteSodium Selenite results in increased expression of HAX1 mRNA24383545
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HAX1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HAX1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAX1 mRNA17942748
D019284ThapsigarginThapsigargin results in increased expression of HAX1 mRNA22378314
D014108Tosylphenylalanyl Chloromethyl KetoneAcetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]19679660
D014108Tosylphenylalanyl Chloromethyl KetoneHAX1 results in decreased susceptibility to Tosylphenylalanyl Chloromethyl Ketone19679660
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 mRNA19679660
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein19679660
D014415TunicamycinTunicamycin results in increased expression of HAX1 mRNA22378314
C501517UCF 101UCF 101 results in decreased degradation of HAX1 protein19763263
D014635Valproic AcidValproic Acid results in decreased expression of HAX1 mRNA21427059
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of HAX1 mRNA"23246600
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16227293  16971486  17008324  20171186  20631090  20665473  
21217774  21567072  22570112  24188827  25416956  
GO:0019966interleukin-1 binding-IDA11554782  
GO:0047485protein N-terminus binding-IDA11554782  
GO ID GO Term Qualifier Evidence PubMed
GO:0007005mitochondrion organizationNOTIMP17008324  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IMP23001182  
GO:0030833regulation of actin filament polymerization-IMP23001182  
GO:0030854positive regulation of granulocyte differentiation-IMP23001182  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IMP23001182  
GO:0042981regulation of apoptotic process-TAS24522549  
GO:0043066negative regulation of apoptotic process-IMP17008324  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23001182  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IMP23001182  
GO:0051897positive regulation of protein kinase B signaling-IMP23001182  
GO:0071345cellular response to cytokine stimulus-IMP23001182  
GO:1903146regulation of autophagy of mitochondrion-TAS24522549  
GO:1903214regulation of protein targeting to mitochondrion-TAS24522549  
GO:2000251positive regulation of actin cytoskeleton reorganization-IMP23001182  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IEA-  
GO:0005635nuclear envelope-TAS9058808  
GO:0005667transcription factor complex-IDA23001182  
GO:0005739mitochondrion-IDA9058808  
GO:0005741mitochondrial outer membrane-IDA17008324  
GO:0005758mitochondrial intermembrane space-IDA17008324  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005886plasma membrane-IEA-  
GO:0005938cell cortex-IEA-  
GO:0015629actin cytoskeleton-ISS-  
GO:0016529sarcoplasmic reticulum-IEA-  
GO:0030027lamellipodium-ISS-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. (2017 Apr 25)Yin XAm J Med Genet B Neuropsychiatr Genet