Gene: GPNMB

10457
HGFIN|NMB|PLCA3
glycoprotein nmb
protein-coding
7p15.3
Ensembl:ENSG00000136235 MIM:604368 Vega:OTTHUMG00000022811 UniprotKB:Q14956
NC_000007.14
PubMed
0   ANCO-SNPs
OD|ND
0   
8.269e-1 (AD)  8.783e-1 (ND)   (Frontal_Cortex)
9.230e-1 (AD)  7.199e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOB1A0.604
LTBR0.6
MPZL10.595
LOXL30.594
GPSM30.592
PYGL0.59
LYN0.589
LIMD10.588
MYD880.587
PARP90.587

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.342
E2F1-0.34
SLC7A4-0.335
TMEFF2-0.324
PPEF1-0.324
CHAF1A-0.319
LYPD8-0.317
ABCC12-0.314
ADTRP-0.311
C10orf82-0.31

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05996Glembatumumab vedotinBiotechDrug1182215-65-1InvestigationalTarget
ID Drug Name Action PubMed
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in increased expression of GPNMB mRNA26821219
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of GPNMB mRNA26821219
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of GPNMB mRNA"20453058
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of GPNMB mRNA"20713471
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of GPNMB mRNA"28940058
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GPNMB mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GPNMB mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GPNMB mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GPNMB mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of GPNMB mRNA24126418
D020106AcrylamideAcrylamide results in increased expression of GPNMB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPNMB mRNA16483693
D001151ArsenicArsenic affects the expression of GPNMB mRNA18315880
D001151ArsenicArsenic results in increased expression of GPNMB mRNA18315880
D001152ArsenicalsArsenicals results in increased methylation of GPNMB promoter26039340
C006632arsenic trioxidearsenic trioxide results in increased expression of GPNMB mRNA26705709|2782922
D001374AzacitidineAzacitidine results in decreased expression of GPNMB mRNA20823114
C547126AZM551248AZM551248 results in increased expression of GPNMB mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GPNMB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPNMB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPNMB mRNA22228805|2373587
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GPNMB mRNA20823114
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GPNMB mRNA19619570
D004958EstradiolEstradiol results in decreased expression of GPNMB mRNA19619570|2118537
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of GPNMB mRNA]21185374
C053541bicalutamidebicalutamide results in increased expression of GPNMB mRNA15638997
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GPNMB mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of GPNMB mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of GPNMB mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of GPNMB mRNA26063408
C006780bisphenol Abisphenol A affects the expression of GPNMB mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GPNMB mRNA15336504
D019256Cadmium ChlorideCadmium Chloride affects the expression of GPNMB mRNA25596134
D019256Cadmium ChlorideCadmium Chloride affects the expression of GPNMB mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GPNMB mRNA25993096
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPNMB mRNA18654764
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GPNMB mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GPNMB mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GPNMB mRNA15763343
C043211carvedilolcarvedilol results in decreased expression of GPNMB protein20403466
D002509CephaloridineCephaloridine results in increased expression of GPNMB mRNA18500788
C084597chlorcyclizinechlorcyclizine results in increased expression of GPNMB mRNA21058326
C004656chloroacetaldehydechloroacetaldehyde affects the expression of GPNMB mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GPNMB mRNA26272509
D002738ChloroquineChloroquine results in increased expression of GPNMB mRNA19393257
D002746ChlorpromazineChlorpromazine results in increased expression of GPNMB mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPNMB mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GPNMB mRNA28472532
C059262cidofovircidofovir results in decreased expression of GPNMB mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of GPNMB mRNA25596134
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPNMB mRNA18654764
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GPNMB mRNA20971185
D003471CuprizoneCuprizone results in increased expression of GPNMB mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of GPNMB mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of GPNMB mRNA19770486
D016572CyclosporineCyclosporine results in increased expression of GPNMB mRNA21865292|2559613
D000069439DasatinibDasatinib results in increased expression of GPNMB mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GPNMB mRNA23640034
D003703DemecolcineDemecolcine results in increased expression of GPNMB mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GPNMB mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of GPNMB mRNA15763343
D003907DexamethasoneDexamethasone results in increased expression of GPNMB mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GPNMB mRNA]20032058
D016264Dextran SulfateDextran Sulfate results in increased expression of GPNMB mRNA23894361
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GPNMB mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GPNMB mRNA20823114
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GPNMB mRNA28962523
D002945CisplatinCisplatin results in decreased expression of GPNMB mRNA25596134|2739243
D004041Dietary FatsDietary Fats results in decreased expression of GPNMB mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of GPNMB mRNA22609946|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GPNMB mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GPNMB mRNA19638242
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of GPNMB mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GPNMB mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of GPNMB mRNA16314067
D004317DoxorubicinDoxorubicin results in increased expression of GPNMB mRNA28940058
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of GPNMB mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GPNMB mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GPNMB mRNA17351261
C540355fenamidonefenamidone results in increased expression of GPNMB mRNA27029645
D005485FlutamideFlutamide results in decreased expression of GPNMB mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPNMB mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of GPNMB mRNA23649840
C039281furanfuran results in increased expression of GPNMB mRNA26194646
D005839GentamicinsGentamicins results in increased expression of GPNMB mRNA22061828
C001335hexachlorobutadienehexachlorobutadiene results in decreased expression of GPNMB mRNA21905055
C001335hexachlorobutadienehexachlorobutadiene results in increased expression of GPNMB mRNA21905055
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GPNMB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GPNMB mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of GPNMB mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPNMB mRNA26752646
D048628KetolidesKetolides analog results in increased expression of GPNMB mRNA24967691
D007854LeadLead affects the expression of GPNMB mRNA28903495
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of GPNMB mRNA18654764
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GPNMB mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GPNMB mRNA15763343
D008154LucanthoneLucanthone results in increased expression of GPNMB mRNA21148553
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GPNMB mRNA20823114
C011907melaminemelamine results in increased expression of GPNMB23052191
C042720mercuric bromidemercuric bromide results in increased expression of GPNMB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of GPNMB mRNA16507785
D008687MetforminMetformin results in increased expression of GPNMB mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of GPNMB mRNA25290377
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPNMB mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GPNMB mRNA20713471
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GPNMB mRNA16026605
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GPNMB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPNMB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPNMB mRNA"24911292
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GPNMB mRNA25380136
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of GPNMB mRNA26821219
D009532NickelNickel results in decreased expression of GPNMB mRNA24768652
C028007nickel monoxidenickel monoxide results in increased expression of GPNMB mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of GPNMB mRNA16314067|2271453
D009538NicotineNicotine results in increased expression of GPNMB mRNA23825647
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GPNMB mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GPNMB mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GPNMB mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of GPNMB mRNA25596134
D010100OxygenOxygen results in increased expression of GPNMB mRNA22911455
D010100OxygenOxygen results in increased expression of GPNMB protein22911455
D017239PaclitaxelPaclitaxel results in increased expression of GPNMB mRNA18754875
D000073878Palm OilPalm Oil results in decreased expression of GPNMB mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of GPNMB mRNA23085030
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GPNMB mRNA26705709
D010615PhenacetinPhenacetin results in increased expression of GPNMB mRNA17082564|1769850
C030299phenylhydrazinephenylhydrazine results in increased expression of GPNMB mRNA17082564|1769850
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPNMB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GPNMB mRNA26272509
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of GPNMB mRNA21334430
D011441PropylthiouracilPropylthiouracil results in increased expression of GPNMB mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GPNMB mRNA27029645
D011794QuercetinQuercetin results in decreased expression of GPNMB mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of GPNMB mRNA]21185374
C031389resorcinolresorcinol results in increased expression of GPNMB mRNA22623647
C010327salinomycinsalinomycin results in decreased expression of GPNMB mRNA19682730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GPNMB mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of GPNMB mRNA26345256
D012822Silicon DioxideSilicon Dioxide results in increased expression of GPNMB mRNA18685790|2243100
D020123SirolimusSirolimus results in increased expression of GPNMB mRNA21865292
D012906SmokeSmoke affects the expression of GPNMB mRNA23693141
C017947sodium arsenitesodium arsenite results in increased expression of GPNMB mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of GPNMB mRNA alternative form21281968
C016104sodium bichromatesodium bichromate results in increased expression of GPNMB mRNA25993096
D053260SootSoot results in increased expression of GPNMB mRNA22461453|2655175
D016559TacrolimusTacrolimus results in increased expression of GPNMB mRNA21865292
D013629TamoxifenTamoxifen affects the expression of GPNMB mRNA17555576
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GPNMB mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GPNMB mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GPNMB mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPNMB mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPNMB mRNA26290441|2756255
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPNMB mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of GPNMB mRNA28973375
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GPNMB mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of GPNMB mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of GPNMB mRNA19464567|2313150
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GPNMB mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GPNMB mRNA18087596
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GPNMB protein27818348
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GPNMB mRNA25729387
D019772TopotecanTopotecan results in increased expression of GPNMB mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of GPNMB mRNA"17951470
D014212TretinoinTretinoin results in increased expression of GPNMB mRNA16249480
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GPNMB mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of GPNMB mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GPNMB mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of GPNMB mRNA19140230
C057693troglitazonetroglitazone results in increased expression of GPNMB mRNA25596134
D017973Tungsten CompoundsTungsten Compounds results in increased expression of GPNMB mRNA28666766
D014520UrethaneUrethane results in decreased expression of GPNMB mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of GPNMB mRNA15885361
D014635Valproic AcidValproic Acid results in decreased expression of GPNMB mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of GPNMB mRNA23179753|2718838
D014638VanadatesVanadates results in decreased expression of GPNMB mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GPNMB gene25560391
C025643vinclozolinvinclozolin affects the expression of GPNMB mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of GPNMB mRNA23034163
D014750VincristineVincristine results in increased expression of GPNMB mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of GPNMB mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of GPNMB mRNA"25198161
C088658zoledronic acidzoledronic acid results in decreased expression of GPNMB mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO:0005515protein binding-IPI12609765  26751287  
GO:0008201heparin binding-IDA19350579  
GO:0042056chemoattractant activity-NAS20711474  
GO:0045545syndecan binding-IPI19350579  
GO:0048018receptor ligand activity-IMP19350579  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-IEA-  
GO:0001818negative regulation of cytokine production-IDA19350579  
GO:0001934positive regulation of protein phosphorylation-IDA22891158  
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-IMP19350579  
GO:0007267cell-cell signaling-IMP19350579  
GO:0008285negative regulation of cell proliferation-TAS7814155  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030282bone mineralization-IEA-  
GO:0030335positive regulation of cell migration-IDA20711474  
GO:0031954positive regulation of protein autophosphorylation-IDA19350579  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0034103regulation of tissue remodeling-IDA25010402  
GO:0042130negative regulation of T cell proliferation-IDA19350579  
GO:0045765regulation of angiogenesis-NAS20711474  
GO:0050868negative regulation of T cell activation-IMP19350579  
GO:0050918positive chemotaxis-NAS20711474  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IC22891158  
GO:1901215negative regulation of neuron death-IGI22891158  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-IDA19350579  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IDA12609765  
GO:0042470melanosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8857538PTK6 promotes HIF1A stabilizationTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal