Gene: TACC3

10460
ERIC-1|ERIC1
transforming acidic coiled-coil containing protein 3
protein-coding
4p16.3
Ensembl:ENSG00000013810 MIM:605303 Vega:OTTHUMG00000089535 UniprotKB:Q9Y6A5
NC_000004.12
PubMed
0   ANCO-SNPs
ND
4   
1.864e-1 (AD)  9.017e-1 (ND)   (Frontal_Cortex)
3.590e-1 (AD)  3.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL170.755
FBXL60.736
OGFR0.734
ACD0.733
CENPT0.732
TMEM1450.732
MLXIPL0.732
IFFO10.731
ATP13A10.729
IMPDH10.729

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.446
OR4F29-0.42
LRAT-0.341
HORMAD2-0.327
NXT2-0.315
ZFHX4-AS1-0.306
IL20RA-0.295
HHLA2-0.287
NUP62CL-0.282
IL33-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TACC3 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TACC3 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of TACC3 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TACC3 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TACC3 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TACC3 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TACC3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TACC3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TACC3 mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of TACC3 mRNA17942131
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TACC3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TACC3 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TACC3 mRNA21298039
C103505AM 251AM 251 results in decreased expression of TACC3 mRNA16500647
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TACC3 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TACC3 mRNA24449571
D001151ArsenicArsenic affects the methylation of TACC3 gene25304211
D001241AspirinAspirin results in decreased expression of TACC3 mRNA15928584
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TACC3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TACC3 mRNA17942131|1977048
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TACC3 mRNA20504355|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TACC3 mRNA"19150397|2038263
D004958EstradiolEstradiol results in increased expression of TACC3 mRNA16474171|1916744
D004958EstradiolEstradiol results in increased expression of TACC3 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of TACC3 mRNA21786754
C006780bisphenol Abisphenol A binds to TACC3 protein20403423
C006780bisphenol Abisphenol A results in decreased expression of TACC3 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TACC3 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of TACC3 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of TACC3 mRNA17942131|1895870
D002220CarbamazepineCarbamazepine affects the expression of TACC3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TACC3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TACC3 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TACC3 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TACC3 gene20938992
D003033Coal TarCoal Tar results in increased expression of TACC3 mRNA27858113
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TACC3 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of TACC3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TACC3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TACC3 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TACC3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of TACC3 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of TACC3 mRNA17942131
D000069439DasatinibDasatinib results in decreased expression of TACC3 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TACC3 mRNA23640034
D003976DiazinonDiazinon affects the expression of TACC3 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TACC3 mRNA17361019
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TACC3 mRNA28962523
D002945CisplatinCisplatin results in increased expression of TACC3 mRNA21151649
D004026DieldrinDieldrin results in increased expression of TACC3 mRNA20584760|2304172
D002117CalcitriolCalcitriol results in decreased expression of TACC3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TACC3 mRNA21592394
D004147DioxinsDioxins affects the expression of TACC3 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TACC3 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TACC3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TACC3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TACC3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TACC3 mRNA17351261
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TACC3 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TACC3 gene20938992
D019833GenisteinGenistein results in increased expression of TACC3 mRNA16474171
D005944GlucosamineGlucosamine results in decreased expression of TACC3 mRNA17109745
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TACC3 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TACC3 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of TACC3 mRNA26191083
C544151jinfukangjinfukang results in increased expression of TACC3 mRNA27392435
C410337K 7174K 7174 results in decreased expression of TACC3 mRNA24086573
D007854LeadLead affects the expression of TACC3 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of TACC3 mRNA28988120
D008713MethimazoleMethimazole results in decreased expression of TACC3 mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TACC3 gene20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TACC3 mRNA24657277
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TACC3 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TACC3 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TACC3 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TACC3 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TACC3 mRNA"20188158
D009151Mustard GasMustard Gas results in decreased expression of TACC3 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TACC3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TACC3 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TACC3 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TACC3 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of TACC3 mRNA26516004
D010126OzoneOzone results in decreased expression of TACC3 mRNA24336422
D010126OzoneOzone results in increased expression of TACC3 mRNA25658374
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TACC3 mRNA]19555225
D017239PaclitaxelPaclitaxel results in decreased expression of TACC3 protein15907983
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TACC3 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of TACC3 mRNA24642059
C494474perchlorateperchlorate results in decreased expression of TACC3 mRNA17403546
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TACC3 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TACC3 mRNA19136022|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of TACC3 mRNA19482888
C006253pirinixic acidpirinixic acid affects the expression of TACC3 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of TACC3 mRNA17950772|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of TACC3 mRNA]21318169
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of TACC3 mRNA]17950772
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TACC3 mRNA16474171
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TACC3 mRNA22698814
D011441PropylthiouracilPropylthiouracil results in increased expression of TACC3 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of TACC3 mRNA17403546
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TACC3 mRNA19167446
D012834SilverSilver results in decreased expression of TACC3 mRNA26551752
C009277sodium arsenatesodium arsenate results in decreased expression of TACC3 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of TACC3 mRNA28595984
D053260SootSoot results in increased expression of TACC3 mRNA22461453|2655175
D014284TriiodothyronineTriiodothyronine affects the expression of TACC3 mRNA17403546
D013629TamoxifenTamoxifen affects the expression of TACC3 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TACC3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TACC3 mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TACC3 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of TACC3 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TACC3 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of TACC3 mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TACC3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TACC3 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of TACC3 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of TACC3 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of TACC3 mRNA23555832
C029297vinylidene chloridevinylidene chloride results in increased expression of TACC3 mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of TACC3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20360068  21297582  25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0007091metaphase/anaphase transition of mitotic cell cycle-IMP23532825  
GO:0008283cell proliferation-IBA21873635  
GO:0021987cerebral cortex development-IBA21873635  
GO:0051301cell division-IEA-  
GO:0060236regulation of mitotic spindle organization-IMP21297582  
GO:1902850microtubule cytoskeleton organization involved in mitosis-IMP23532825  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0072686mitotic spindle-IDA-  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26531241The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer. (2016 Jan)Jiang FOncol Rep
24850843FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)Wang RClin Cancer Res
24155119Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. (2014 Jan)Wang PGenes Chromosomes Cancer
27785367FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer. (2016 Oct)Theelen WSJ Pathol Clin Res