Gene: MERTK

10461
MER|RP38|Tyro12|c-Eyk|c-mer
MER proto-oncogene, tyrosine kinase
protein-coding
2q13
Ensembl:ENSG00000153208 MIM:604705 Vega:OTTHUMG00000131278 UniprotKB:Q12866
NG_011607.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.345e-1 (AD)  6.682e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOTCH20.886
MID10.882
CDC14A0.877
PAX60.872
BCAR30.869
GRAMD1C0.869
SLC1A30.869
RFX20.868
GJA10.865
SLC39A120.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP6-0.429
GPD1-0.427
CRHBP-0.412
TMEFF2-0.412
DUSP27-0.405
CYP26A1-0.403
AGMAT-0.403
QRFPR-0.397
PPEF1-0.395
CPXM2-0.395

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB083252-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of MERTK protein"21608528
D000082AcetaminophenAcetaminophen results in increased expression of MERTK mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MERTK mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MERTK mRNA]17585979
D000244Adenosine DiphosphateMERTK protein results in increased susceptibility to Adenosine Diphosphate15733062
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MERTK gene27153756
D000452Aldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MERTK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MERTK mRNA24449571
C058317arsenic disulfidearsenic disulfide results in decreased expression of MERTK mRNA12890387
C006632arsenic trioxidearsenic trioxide results in decreased expression of MERTK mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MERTK mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MERTK gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MERTK mRNA21569818|2222880
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA24758408
D004958EstradiolEstradiol results in increased expression of MERTK mRNA24758408
D004958EstradiolTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA]24758408
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of MERTK mRNA]24758408
C006780bisphenol Abisphenol A results in decreased expression of MERTK mRNA25181051
D001761BleomycinBleomycin affects the localization of and affects the expression of MERTK protein22687607
D001761BleomycinBleomycin results in increased phosphorylation of MERTK protein22687607
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MERTK mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MERTK mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MERTK mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MERTK mRNA27339419
D002737ChloropreneChloroprene results in increased expression of MERTK mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MERTK mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MERTK mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of MERTK mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MERTK mRNA]17585979
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MERTK mRNA20971185
D003471CuprizoneCuprizone results in increased expression of MERTK mRNA27523638
D003561CytarabineCytarabine results in decreased expression of MERTK mRNA21198554
D003634DDT[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
C014347decitabinedecitabine affects the expression of MERTK mRNA23300844
D003907DexamethasoneDexamethasone results in increased expression of MERTK mRNA22733784
D002945CisplatinCisplatin affects the expression of MERTK mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MERTK mRNA27392435
D002945CisplatinCisplatin results in increased expression of MERTK mRNA27392435
D003632Dichlorodiphenyldichloroethane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D004026Dieldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D004041Dietary FatsDietary Fats results in decreased expression of MERTK mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of MERTK mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MERTK mRNA21592394
D004732Endrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D011345FenofibrateFenofibrate results in increased expression of MERTK mRNA25572481
C010974glyphosateglyphosate results in increased expression of MERTK mRNA25636363
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MERTK mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MERTK mRNA24796395|2530787
C008261lead acetatelead acetate results in increased expression of MERTK mRNA22641619
D001556Lindane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
D008070LipopolysaccharidesLipopolysaccharides results in increased cleavage of MERTK protein17047157
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MERTK mRNA25890327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MERTK mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in increased expression of MERTK mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MERTK mRNA"25554681
C000621033napabucasinnapabucasin results in decreased expression of MERTK mRNA25605917
D009532NickelNickel results in decreased expression of MERTK mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of MERTK mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MERTK mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MERTK mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MERTK mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of MERTK mRNA18042831
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MERTK mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MERTK mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of MERTK mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of MERTK mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MERTK mRNA27029645
D012402RotenoneRotenone results in increased expression of MERTK mRNA19013527
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of MERTK mRNA"21148743
D012715Sesame OilSesame Oil results in increased expression of MERTK mRNA29191790
D019821Simvastatin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA28263720
C017947sodium arsenitesodium arsenite results in increased expression of MERTK mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of MERTK mRNA16014739
C016104sodium bichromatesodium bichromate results in decreased expression of MERTK mRNA17685462
D018038Sodium SeleniteSodium Selenite results in decreased expression of MERTK mRNA23274088
D053260SootSoot results in increased expression of MERTK mRNA26551751
D013629TamoxifenTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA]24758408
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of MERTK mRNA]24758408
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MERTK mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MERTK mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MERTK mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MERTK mRNA22298810
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased cleavage of MERTK protein17047157
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MERTK mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of MERTK mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of MERTK mRNA24935251
D014520UrethaneUrethane results in increased expression of MERTK mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MERTK mRNA19101580|2317975
D014638VanadatesVanadates results in decreased expression of MERTK mRNA22714537
C029297vinylidene chloridevinylidene chloride results in decreased expression of MERTK mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI20103767  
GO:0005524ATP binding-IEA-  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001779natural killer cell differentiation-IEA-  
GO:0001818negative regulation of cytokine production-IEA-  
GO:0006468protein phosphorylation-TAS8086340  
GO:0006909phagocytosis-IBA21873635  
GO:0006909phagocytosis-IMP19204785  
GO:0007166cell surface receptor signaling pathway-TAS8086340  
GO:0007267cell-cell signaling-TAS8086340  
GO:0007275multicellular organism development-IBA21873635  
GO:0007283spermatogenesis-IEA-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030168platelet activation-IEA-  
GO:0032940secretion by cell-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0034446substrate adhesion-dependent cell spreading-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043277apoptotic cell clearance-IEA-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043491protein kinase B signaling-IEA-  
GO:0050766positive regulation of phagocytosis-IDA18395422  
GO:0050900leukocyte migration-TAS-  
GO:0051250negative regulation of lymphocyte activation-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0060068vagina development-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0097350neutrophil clearance-IEA-  
GO:2000107negative regulation of leukocyte apoptotic process-IMP23353780  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0005615extracellular space-IDA18395422  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA18395422  19204785  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8086340  
GO:0016028rhabdomere-IDA19204785  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18587056Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. (2008 Dec)Kazeros AAm J Respir Cell Mol Biol
29359540Association between Genetic Variations of MERTK and Chronic Obstructive Pulmonary Disease in Koreans. (2018 Feb 12)Kim WJJ Korean Med Sci