Gene info: ID 10468

Gene: FST

GENE ID: 10468

Synonyms: FS

Description: follistatin

Gene type: protein-coding

Location: 5q11.2

dbXrefs: Ensembl:ENSG00000134363 MIM:136470 Vega:OTTHUMG00000131183 UniprotKB:P19883

RefSeq: NG_028911.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 18

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.962e-1 (AD) 3.676e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPTY2D1	0.613
TNFSF18	0.606
PPARG	0.603
TXNRD1	0.601
DHRS2	0.6
NKX3-1	0.592
ALDH1A2	0.591
CCL1	0.588
GCLM	0.585
PNO1	0.582

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
P2RY14	-0.312
APCDD1	-0.283
SLC6A13	-0.273
PGLYRP1	-0.27
TNS3	-0.26
C16orf96	-0.256
GPR17	-0.253
TEX22	-0.25
GLI1	-0.247
SNX22	-0.247

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01666	D-Myo-Inositol-Hexasulphate	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FST mRNA	28329830
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FST mRNA	19933214
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	23196670
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FST mRNA"	23196670
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of FST mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of FST mRNA"	19561079
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to FST protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to FST protein]	26598702
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of FST mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of FST mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FST gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of FST mRNA	21641981
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of FST mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FST mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of FST mRNA	24449571
C519728	archazolid B	archazolid B results in decreased expression of FST mRNA	25218289
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of FST mRNA	18585445
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to FST protein]	26598702
C015001	arsenite	arsenite results in decreased expression of FST mRNA	23974009
C015001	arsenite	arsenite results in increased methylation of FST promoter	23974009
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of FST mRNA	15894712
C015001	arsenite	arsenite results in decreased expression of FST mRNA	15894712
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of FST mRNA"	24160326
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of FST mRNA"	18687144\|2535159
D001241	Aspirin	Aspirin affects the expression of FST mRNA	12800193
D001280	Atrazine	Atrazine results in decreased expression of FST mRNA	25929836
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of FST mRNA	18585445
D001379	Azathioprine	Azathioprine results in increased expression of FST mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased expression of FST mRNA	22323515
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of FST mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FST mRNA	22178795
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FST mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of FST mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FST mRNA	15894712\|1977048
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FST mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FST mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FST mRNA"	19150397\|2623829
D004958	Estradiol	Estradiol affects the expression of FST mRNA	14699072
D004958	Estradiol	Estradiol results in decreased expression of FST mRNA	16298037
D004958	Estradiol	Estradiol results in decreased expression of FST mRNA	23144751
D004958	Estradiol	Estradiol results in decreased expression of FST mRNA alternative form	22285243
D004958	Estradiol	Estradiol results in increased expression of FST mRNA	19484750
C006780	bisphenol A	bisphenol A affects the expression of FST mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of FST mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FST mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of FST mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FST mRNA	28628672
D020148	Butyric Acid	Butyric Acid results in decreased expression of FST mRNA	12800193
C584509	C646 compound	C646 compound results in decreased expression of FST mRNA	26921506
D002104	Cadmium	Cadmium results in decreased expression of FST mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of FST mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of FST promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FST mRNA	27339419
C100187	chloropicrin	chloropicrin affects the expression of FST mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of FST mRNA	28476498
D002737	Chloroprene	Chloroprene results in increased expression of FST mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of FST mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FST mRNA	24386269
D005576	Colforsin	FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]	18936084
D005576	Colforsin	FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]	18936084
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of FST mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FST mRNA	19549813
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	11007951
D016572	Cyclosporine	Cyclosporine results in decreased expression of FST mRNA	25562108\|2798913
C014347	decitabine	decitabine results in increased expression of FST mRNA	16367923
C014347	decitabine	decitabine results in increased expression of FST mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FST mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FST mRNA	28628672
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of FST mRNA]	21149847
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of FST mRNA"	25908611
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of FST mRNA	28962523
D002945	Cisplatin	Cisplatin affects the reaction [Piroxicam results in decreased expression of FST mRNA]	21858171
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FST mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of FST mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of FST mRNA	22023808
C000944	dicrotophos	dicrotophos results in increased expression of FST mRNA	28302478
D004026	Dieldrin	Dieldrin results in decreased expression of FST mRNA	23041725
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of FST mRNA	27495896
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of FST protein	27495896
C058705	diethyl malate	diethyl malate affects the expression of FST mRNA	24814887
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of FST mRNA	24535843
D002117	Calcitriol	Calcitriol results in decreased expression of FST protein	23589129
D002117	Calcitriol	FST protein inhibits the reaction [Calcitriol results in decreased expression of CLEC3B mRNA]	23589129
D002117	Calcitriol	FST protein inhibits the reaction [Calcitriol results in decreased expression of SMAD7 mRNA]	23589129
D002117	Calcitriol	FST protein promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]	23589129
D004237	Diuron	Diuron results in decreased expression of FST mRNA	25152437
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
D004967	Estrogens	Estrogens results in increased expression of FST mRNA	8612495
D004967	Estrogens	Pentobarbital inhibits the reaction [Estrogens results in increased expression of FST mRNA]	8612495
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of FST mRNA	16551644\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FST mRNA	12655037\|1583489
D015025	Zearalenone	Zearalenone results in decreased expression of FST mRNA	25455459
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FST mRNA	28329830
D005557	Formaldehyde	Formaldehyde results in increased expression of FST mRNA	27664576
D005620	Freund's Adjuvant	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of FST mRNA]	21149847
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of FST mRNA	21149847
C070081	fulvestrant	fulvestrant results in increased expression of FST mRNA	16298037
C039281	furan	furan results in increased expression of FST mRNA	24183702
C039281	furan	furan results in increased expression of FST mRNA	27387713
D019833	Genistein	Genistein results in decreased expression of FST mRNA	26865667
C412815	GW 4064	GW 4064 results in decreased expression of FST mRNA	26655953
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of FST mRNA	17183730
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of FST	18687144
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FST mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FST mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FST mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FST mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FST mRNA	28628672
D007529	Isoflavones	Isoflavones results in decreased expression of FST mRNA	16365062
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FST mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of FST mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of FST mRNA	17085751
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of FST mRNA	24231268
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FST mRNA	26644586
C410337	K 7174	K 7174 results in increased expression of FST mRNA	24086573
C031895	lead chromate	lead chromate results in increased expression of FST mRNA	23584427
C045463	leflunomide	leflunomide results in increased expression of FST mRNA	28988120
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA	16415329
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of FST mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA]	16415329
D008694	Methamphetamine	Methamphetamine results in decreased expression of FST mRNA	28619521
D008696	Methandrostenolone	Methandrostenolone results in decreased expression of FST mRNA	21818626
D008727	Methotrexate	Methotrexate affects the expression of FST mRNA	18502557
D008731	Methoxychlor	Methoxychlor results in decreased expression of FST mRNA	23303685
D008731	Methoxychlor	Methoxychlor results in increased methylation of FST gene	23303685
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of FST mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FST mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FST mRNA"	27188386
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of FST mRNA	15120970
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of FST mRNA	19162170
D009151	Mustard Gas	Mustard Gas results in decreased expression of FST mRNA	25102026
D009151	Mustard Gas	Mustard Gas results in increased expression of FST mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FST mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of FST mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FST mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in increased expression of FST mRNA	16100012
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of FST mRNA	17616710
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of FST mRNA	20971185
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of FST mRNA	24888373
D009966	Orphenadrine	Orphenadrine affects the expression of FST mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of FST mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of FST mRNA	25729387
D010100	Oxygen	Oxygen affects the reaction [AHR protein results in increased expression of FST mRNA]	27103661
D010100	Oxygen	Oxygen deficiency results in decreased expression of FST mRNA	24236059\|2651600
D010269	Paraquat	Paraquat results in increased expression of FST mRNA	15458575
D052638	Particulate Matter	Particulate Matter results in decreased expression of FST mRNA	22178795
D010424	Pentobarbital	Pentobarbital inhibits the reaction [Estrogens results in increased expression of FST mRNA]	8612495
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of FST mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of FST mRNA	19162173
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of FST mRNA	26678675
D010634	Phenobarbital	Phenobarbital affects the expression of FST mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FST mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of FST mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of FST mRNA	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of FST mRNA	19162173
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FST mRNA	19710929
D010894	Piroxicam	Cisplatin affects the reaction [Piroxicam results in decreased expression of FST mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of FST mRNA	21858171
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of FST mRNA	24888373
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of FST mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of FST mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of FST mRNA	20876846
D011374	Progesterone	FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]	18936084
D011374	Progesterone	FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]	18936084
D011374	Progesterone	Progesterone results in increased expression of FST mRNA	22238285
D011374	Progesterone	Progesterone results in increased expression of FST mRNA alternative form	22285243
C045950	propiconazole	propiconazole results in increased expression of FST mRNA	19363144
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FST mRNA	24780913
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of FST mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA	19059307
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA	16415329
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA]	16415329
C059514	resveratrol	resveratrol results in increased expression of FST mRNA	17257620\|2588880
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of FST mRNA"	24160326
C009250	sevoflurane	sevoflurane affects the expression of FST mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog affects the expression of FST mRNA	25895662
D012906	Smoke	Smoke affects the expression of FST mRNA	23693141
C017947	sodium arsenite	sodium arsenite results in decreased expression of FST mRNA	16014739
C016104	sodium bichromate	sodium bichromate results in increased expression of FST mRNA	22561333
D053260	Soot	Soot results in increased expression of FST mRNA	22461453\|2655175
D013629	Tamoxifen	Tamoxifen affects the expression of FST mRNA	14699072
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FST mRNA	19059307
D013629	Tamoxifen	Tamoxifen results in decreased expression of FST mRNA	16298037
D013739	Testosterone	FST mutant form inhibits the reaction [Testosterone results in increased expression of MYH2 protein]	22138414
D013739	Testosterone	Testosterone results in increased expression of FST mRNA	22138414
D013739	Testosterone	Testosterone results in increased expression of FST protein	22138414
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FST mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FST mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FST protein	16083274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FST mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FST mRNA	19770486\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FST mRNA	17586704
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	23196670
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	23196670
D013749	Tetrachlorodibenzodioxin	ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FST mRNA]	23196670
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FST mRNA	23196670
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FST mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of FST mRNA	23409001
C009495	titanium dioxide	titanium dioxide results in increased expression of FST mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FST mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of FST mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of FST mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of FST mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of FST mRNA	21934132
D014212	Tretinoin	Tretinoin results in decreased expression of FST mRNA	16604517
C032910	triadimefon	triadimefon results in increased expression of FST mRNA	19363144
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of FST mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FST mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of FST mRNA	19140230
C057693	troglitazone	troglitazone results in increased expression of FST mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in increased expression of FST mRNA	15458575
D014520	Urethane	Urethane results in increased expression of FST mRNA	28818685
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of FST mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FST mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of FST mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FST mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of FST mRNA	23179753
D014635	Valproic Acid	Valproic Acid affects the expression of FST mRNA	17292431\|1796380
D014640	Vancomycin	Vancomycin results in decreased expression of FST mRNA	18930951
D002762	Cholecalciferol	Cholecalciferol results in increased expression of FST mRNA	17170073
D014810	Vitamin E	Vitamin E results in increased expression of FST mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	16198295 17991437 20860622
GO:0043395	heparan sulfate proteoglycan binding	-	IEA	-
GO:0048185	activin binding	-	IPI	12697670

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	12702211
GO:0002244	hematopoietic progenitor cell differentiation	-	IDA	15451575
GO:0032926	negative regulation of activin receptor signaling pathway	-	IDA	11948405 12697670
GO:0051798	positive regulation of hair follicle development	-	IDA	12514121

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-

KEGG ID	KEGG Term
hsa04350	TGF-beta signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1502540	Signaling by Activin	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-2473224	Antagonism of Activin by Follistatin	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21324836	Interactions between endocannabinoid and serotonergic systems in mood disorders caused by nicotine withdrawal. (2011 Apr)	Mannucci C	Nicotine Tob Res
24682499	The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice. (2014 Aug)	Roni MA	Psychopharmacology (Berl)
25081549	Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress. (2015 Nov)	Retson TA	Brain Struct Funct
24189487	The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (2014 Mar)	Witkin JM	Pharmacol Ther
20153341	Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal. (2010 Jun)	Zaniewska M	Neuropharmacology
11549750	Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. (2001 Sep 15)	Pliakas AM	J Neurosci
16970620	Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations. (2005 Feb)	Ma L	Hereditas
11898876	Normative data for vascular and neurological tests of the hand-arm vibration syndrome. (2002 Jan)	Lindsell CJ	Int Arch Occup Environ Health
27917110	Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens. (2016)	Lee KM	Front Cell Neurosci
22526543	Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. (2013 Apr)	Jackson KJ	Psychopharmacology (Berl)
12050823	A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. (2002 Jul)	Osier MV	Am J Hum Genet
29109058	Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking. (2018 Jan)	Lee KM	Neuropharmacology
25309774	Nicotine Blocks the Depressogenic Effects of Alcohol: Implications for Drinking-Smoking Co-Morbidity. (2013 Jul 1)	Kalejaiye O	J Drug Alcohol Res
20069419	Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats. (2010 Mar)	Villegier AS	Psychopharmacology (Berl)
27624598	Long-lasting effects of adolescent oxycodone exposure on reward-related behavior and gene expression in mice. (2016 Dec)	Sanchez V	Psychopharmacology (Berl)
29704590	Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. (2018 Apr 25)	Yawalkar R	Neurochem Int
24816773	Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. (2014)	Cohen A	PLoS One
18991883	Hormonal, neurochemical, and behavioral response to a forced swim test in adolescent rats throughout cocaine withdrawal. (2008 Oct)	Alves CJ	Ann N Y Acad Sci