Gene: CEACAM5

1048
CD66e|CEA
carcinoembryonic antigen related cell adhesion molecule 5
protein-coding
19q13.2
Ensembl:ENSG00000105388 MIM:114890 Vega:OTTHUMG00000151061 UniprotKB:P06731
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.534e-1 (AD)  4.216e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC210.761
KRT6A0.73
SPINK50.718
SPRR1A0.717
SERPINB30.71
SPRR2A0.696
SPRR2D0.694
KLK130.679
KRT130.678
ADH70.675

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CATSPER3-0.218
AGAP4-0.214
KIF15-0.211
PM20D2-0.204
PKD1L1-0.203
ZNF717-0.2
KLHL41-0.199
PTRH1-0.197
C1QTNF9B-0.192
C1orf146-0.192

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08217S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CEACAM5 mRNA"16269432
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM5 mRNA17690111
D000393Air PollutantsAir Pollutants analog results in increased expression of CEACAM5 mRNA21757418
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM5 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CEACAM5 mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEACAM5 protein21467743
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of CEACAM5 mRNA19619570|2118537
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of CEACAM5 mRNA17404688
D003976DiazinonDiazinon results in increased methylation of CEACAM5 gene22964155
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CEACAM5 mRNA"17690111
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CEACAM5 mRNA20044591
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CEACAM5 mRNA26752646
D007854LeadLead results in decreased expression of CEACAM5 mRNA19921347
D008727MethotrexateMethotrexate results in increased expression of CEACAM5 mRNA17400583
D009532NickelNickel results in decreased expression of CEACAM5 mRNA25583101
C558013NSC 689534NSC 689534 results in increased expression of CEACAM5 mRNA20971185
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of CEACAM5 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of CEACAM5 mRNA17404688
D011794QuercetinQuercetin results in decreased expression of CEACAM5 mRNA15309432
D015474Isotretinoin[vorinostat co-treated with Isotretinoin] results in increased expression of CEACAM5 mRNA18769122
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CEACAM5 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CEACAM5 mRNA25351596
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEACAM5 mRNA19619570
C416660thiamethoxamthiamethoxam results in increased expression of CEACAM5 protein29197058
D014635Valproic AcidValproic Acid affects the expression of CEACAM5 mRNA17963808
C111237vorinostat[vorinostat co-treated with Isotretinoin] results in increased expression of CEACAM5 mRNA18769122
C088658zoledronic acidzoledronic acid results in increased expression of CEACAM5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0034235GPI anchor binding-IMP10931872  
GO:0042802identical protein binding-IDA26483485  
GO:0042802identical protein binding-IPI10864933  18086185  
GO:0042803protein homodimerization activity-IDA18086185  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IMP2803308  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IMP2803308  
GO:0010832negative regulation of myotube differentiation-IDA8408226  10931872  
GO:0034109homotypic cell-cell adhesion-IDA10864933  
GO:0043066negative regulation of apoptotic process-IDA11448920  
GO:0050900leukocyte migration-TAS-  
GO:2000811negative regulation of anoikis-IDA10910050  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA10931872  
GO:0009986cell surface-IC2803308  
GO:0009986cell surface-IDA2317824  
GO:0016323basolateral plasma membrane-IDA15052268  
GO:0016324apical plasma membrane-IDA10436421  
GO:0031225anchored component of membrane-IDA2317824  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0071575integral component of external side of plasma membrane-IDA10864933  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23941132Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. (2013 Aug 14)Klaile ERespir Res