Gene: CAP1

10487
CAP|CAP1-PEN
cyclase associated actin cytoskeleton regulatory protein 1
protein-coding
1p34.2
Ensembl:ENSG00000131236 MIM:617801 Vega:OTTHUMG00000004493 UniprotKB:Q01518
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.469e-1 (AD)  6.908e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16826852chr1:40065422 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB7A0.948
ILF20.947
HNRNPK0.947
XRCC50.946
PCBP20.945
GDI20.941
UBE2D30.941
KPNB10.939
ADIPOR10.936
TMED20.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.85
OR4F29-0.828
TCL1A-0.157
MTRNR2L6-0.141
PRDM14-0.131
HMHB1-0.124
PRAMEF17-0.122
OR52H1-0.12
OR6C74-0.12
OR2A14-0.119

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of CAP1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CAP1 mRNA"18648102
C0275764-hydroxy-2-nonenalCAP1 protein binds to 4-hydroxy-2-nonenal20043646
D000082AcetaminophenAcetaminophen results in increased expression of CAP1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CAP1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CAP1 mRNA16483693
C038328BEP protocolBEP protocol results in decreased expression of CAP1 mRNA18987330
D004958EstradiolEstradiol results in increased expression of CAP1 mRNA21632981
C006780bisphenol Abisphenol A results in decreased expression of CAP1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CAP1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of CAP1 mRNA24136188
D002101Cacodylic AcidCacodylic Acid results in increased expression of CAP1 mRNA16122865
D002104CadmiumCadmium results in increased oxidation of CAP1 protein24077948
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CAP1 mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of CAP1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of CAP1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of CAP1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of CAP1 protein25470785
D016572CyclosporineCyclosporine results in increased expression of CAP1 mRNA25562108
D013759DronabinolDronabinol results in increased expression of CAP1 mRNA21955143
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CAP1 mRNA21266533
D004147DioxinsDioxins affects the expression of CAP1 mRNA20463971
D004317DoxorubicinDoxorubicin affects the expression of CAP1 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CAP1 protein23301498
D000431EthanolEthanol results in decreased expression of CAP1 mRNA21955143
D019833GenisteinGenistein affects the expression of CAP1 mRNA18214933
D005839GentamicinsGentamicins results in increased expression of CAP1 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of CAP1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAP1 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of CAP1 mRNA16835149
D007854LeadLead results in decreased expression of CAP1 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CAP1 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CAP1 protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CAP1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CAP1 protein24806433
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CAP1 protein24675778
D008777MethyltestosteroneMethyltestosterone results in increased expression of CAP1 mRNA29191790
D009020MorphineMorphine results in decreased expression of CAP1 mRNA21955143
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of CAP1 protein19438287
D009538NicotineNicotine results in decreased expression of CAP1 mRNA21955143
C012655nimesulidenimesulide results in decreased expression of CAP1 mRNA24136188
D012715Sesame OilSesame Oil results in decreased expression of CAP1 mRNA29191790
D014284TriiodothyronineTriiodothyronine results in increased expression of CAP1 mRNA17403546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CAP1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAP1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAP1 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CAP1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of CAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CAP1 mRNA23179753|2800136
C025643vinclozolinvinclozolin affects the expression of CAP1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of CAP1 mRNA23034163
D014810Vitamin EVitamin E results in increased expression of CAP1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0008179adenylate cyclase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0001667ameboidal-type cell migration-IEA-  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0007163establishment or maintenance of cell polarity-IBA21873635  
GO:0007163establishment or maintenance of cell polarity-TAS1406678  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS1406678  
GO:0007190activation of adenylate cyclase activity-TAS7962207  
GO:0008154actin polymerization or depolymerization-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0045761regulation of adenylate cyclase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0030864cortical actin cytoskeleton-IBA21873635  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-114608Platelet degranulation IEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76005Response to elevated platelet cytosolic Ca2+IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal