Gene: CREB3

10488
LUMAN|LZIP|sLZIP
cAMP responsive element binding protein 3
protein-coding
9p13.3
Ensembl:ENSG00000107175 MIM:606443 Vega:OTTHUMG00000019872 UniprotKB:O43889
NG_046983.1
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.471e-1 (AD)  5.653e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRSF90.942
YWHAE0.94
PSMC30.939
COX4I10.938
MRFAP10.938
NDUFB80.936
NME1-NME20.935
C1orf430.932
RNF50.931
PARK70.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.885
OR4F5-0.881
C8orf74-0.163
KCNJ15-0.161
CXCR2-0.161
CCR8-0.158
PZP-0.15
KRT73-0.149
NPHS2-0.148
CHIA-0.145

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CREB3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CREB3 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of CREB3 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CREB3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CREB3 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CREB3 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of CREB3 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CREB3 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of CREB3 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CREB3 mRNA16934159
C018021cobaltous chloridecobaltous chloride results in increased expression of CREB3 mRNA24386269
D003474CurcuminCurcumin results in increased expression of CREB3 mRNA18299980
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CREB3 mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of CREB3 mRNA20106945|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CREB3 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CREB3 mRNA21266533
D002117CalcitriolCalcitriol results in increased expression of CREB3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CREB3 mRNA21592394
D000431EthanolEthanol results in decreased expression of CREB3 mRNA20655511
D018120FinasterideFinasteride results in increased expression of CREB3 mRNA24136188
D005485FlutamideFlutamide results in increased expression of CREB3 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of CREB3 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB3 mRNA25613284
C410337K 7174K 7174 results in increased expression of CREB3 mRNA24086573
D008727MethotrexateCREB3 protein affects the susceptibility to Methotrexate16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CREB3 mRNA20886546
C051752nefazodonenefazodone results in increased expression of CREB3 mRNA24136188
D010269ParaquatParaquat results in increased expression of CREB3 mRNA21371552
D012524SarinSarin results in decreased expression of CREB3 mRNA19522546
D012643SeleniumSelenium results in increased expression of CREB3 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of CREB3 mRNA20886546
C061133tamibarotenetamibarotene results in increased expression of CREB3 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CREB3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CREB3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CREB3 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CREB3 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB3 mRNA25613284
D014212TretinoinTretinoin results in increased expression of CREB3 mRNA15498508
C406224valdecoxibvaldecoxib results in increased expression of CREB3 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of CREB3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CREB3 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of CREB3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CREB3 gene25560391
D014810Vitamin EVitamin E results in increased expression of CREB3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA16940180  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16940180  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16940180  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP16940180  
GO:0005515protein binding-IPI10629049  10871379  15705566  17483474  18391022  20102225  
20195357  
GO:0035497cAMP response element binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006935chemotaxis-IEA-  
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response-IDA16940180  
GO:0016032viral process-IEA-  
GO:0030968endoplasmic reticulum unfolded protein response-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16940180  17296613  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16940180  
GO:0090026positive regulation of monocyte chemotaxis-IDA17296613  
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IDA16940180  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005634nucleus-IC16940180  
GO:0005634nucleus-IDA20546900  
GO:0005654nucleoplasm-TAS-  
GO:0005783endoplasmic reticulum-IDA16236796  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381119Unfolded Protein Response (UPR)IEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-8874211CREB3 factors activate genesTAS
R-HSA-8874211CREB3 factors activate genesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22580231Downregulation of cAMP response element-binding protein by lentiviral vector-mediated RNAi attenuates morphine withdrawal syndromes in rats. (2012 Jul 15)Wu QBehav Brain Res