Gene info: ID 10493

SNP ID	Position	Alleles	Trait	Variation Type
rs382571	chr17:43019464 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs429464	chr17:43018881 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

Gene Symbol	Pearson Correlation Coefficient
IMPDH2	0.85
PFN1	0.85
EIF3G	0.828
TPM4	0.828
MYL6	0.824
TXNDC5	0.823
SEC13	0.82
REXO2	0.82
KDELR2	0.82
ARF6	0.816

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.661
OR4F5	-0.654
DIO2	-0.21
REN	-0.182
ZNF98	-0.167
HES5	-0.164
ARSF	-0.161
NXNL1	-0.158
SLC13A5	-0.141
HOXC5	-0.139

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of VAT1 mRNA"	16269432
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of VAT1 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of VAT1 mRNA]"	19414516
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of VAT1 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in increased expression of VAT1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of VAT1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of VAT1 mRNA	28959563
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of VAT1 mRNA]"	19414516
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of VAT1 gene	27153756
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of VAT1 mRNA"	22863853
D001151	Arsenic	Arsenic affects the methylation of VAT1 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of VAT1 mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of VAT1 mRNA	16269432
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of VAT1 mRNA	19770486\|2222880
C006780	bisphenol A	bisphenol A results in increased expression of VAT1 mRNA	27685785\|2927551
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VAT1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of VAT1 protein	18418863
C006780	bisphenol A	bisphenol A affects the expression of VAT1 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of VAT1 mRNA	28628672
C584509	C646 compound	C646 compound results in decreased expression of VAT1 mRNA	26191083
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of VAT1 mRNA	27339419
C100187	chloropicrin	chloropicrin results in decreased expression of VAT1 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of VAT1 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in increased expression of VAT1 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of VAT1 protein	22339908
D003042	Cocaine	Cocaine affects the expression of VAT1 mRNA	20187946
D019327	Copper Sulfate	Copper Sulfate results in increased expression of VAT1 mRNA	19549813
D003375	Coumestrol	Coumestrol results in decreased expression of VAT1 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in increased expression of VAT1 mRNA	25562108
D003907	Dexamethasone	Dexamethasone results in decreased expression of VAT1 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VAT1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of VAT1 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of VAT1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of VAT1 mRNA	21266533
D004041	Dietary Fats	Dietary Fats results in increased expression of VAT1 mRNA	25016146
D004147	Dioxins	Dioxins affects the expression of VAT1 mRNA	20463971
D004221	Disulfiram	Disulfiram results in decreased expression of VAT1 mRNA	20530235
D000431	Ethanol	Ethanol results in increased expression of VAT1 protein	19609968
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of VAT1 mRNA	27776689
D015025	Zearalenone	Zearalenone results in increased expression of VAT1 protein	25058043
D005472	Fluorouracil	Fluorouracil results in increased expression of VAT1 mRNA	16101138
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of VAT1 mRNA	20938992
D019833	Genistein	ESR1 promotes the reaction [Genistein results in decreased expression of VAT1 protein]	20884965
D019833	Genistein	Genistein results in decreased expression of VAT1 protein	20884965
C492448	ICG 001	ICG 001 results in increased expression of VAT1 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VAT1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of VAT1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAT1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VAT1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of VAT1 mRNA	28628672
C544151	jinfukang	jinfukang results in increased expression of VAT1 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of VAT1 mRNA	15476862
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of VAT1 mRNA	24796395
D048628	Ketolides	Ketolides analog results in increased expression of VAT1 mRNA	24967691
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of VAT1 mRNA	12057914
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of VAT1 mRNA	25613284
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of VAT1 mRNA	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of VAT1 mRNA	26011545
C059539	midostaurin	midostaurin results in decreased expression of VAT1 mRNA	20980353
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of VAT1 protein"	21135415
C031721	naphthalene	[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of VAT1 protein	19438287
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of VAT1 mRNA	19812364
C051752	nefazodone	nefazodone results in increased expression of VAT1 mRNA	24136188
C025589	ochratoxin A	ochratoxin A results in decreased expression of VAT1 protein	26861962
C030110	oxaliplatin	oxaliplatin results in increased expression of VAT1 mRNA	25729387
C006253	pirinixic acid	pirinixic acid results in decreased expression of VAT1 mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in decreased expression of VAT1 mRNA	23557933
D011441	Propylthiouracil	Propylthiouracil results in increased expression of VAT1 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of VAT1 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of VAT1 mRNA	21565894
D012643	Selenium	Selenium results in increased expression of VAT1 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of VAT1 mRNA	25895662
D012906	Smoke	Smoke results in increased expression of VAT1 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of VAT1 mRNA	21795629
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of VAT1 protein	28918527
D018038	Sodium Selenite	Sodium Selenite results in increased expression of VAT1 mRNA	18175754
D012999	Soman	Soman results in increased expression of VAT1 mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VAT1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of VAT1 mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VAT1 mRNA	18796159\|2121527
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of VAT1 mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of VAT1 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of VAT1 mRNA	23411599
D013893	Thiram	Thiram results in decreased expression of VAT1 mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of VAT1 mRNA	23131501
D014212	Tretinoin	Tretinoin results in decreased expression of VAT1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of VAT1 mRNA	16054129
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of VAT1 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of VAT1 mRNA	19140230
D014635	Valproic Acid	Valproic Acid affects the expression of VAT1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of VAT1 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid affects the expression of VAT1 mRNA	17292431
D014640	Vancomycin	Vancomycin results in decreased expression of VAT1 mRNA	18930951
C025643	vinclozolin	vinclozolin affects the expression of VAT1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of VAT1 mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of VAT1 mRNA	22570695
C029297	vinylidene chloride	vinylidene chloride results in increased expression of VAT1 mRNA	26682919
D014810	Vitamin E	Vitamin E results in increased expression of VAT1 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of VAT1 protein	20543569

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008270	zinc ion binding	-	IEA	-
GO:0016491	oxidoreductase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010637	negative regulation of mitochondrial fusion	-	IMP	17105775
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005741	mitochondrial outer membrane	-	IEA	-
GO:0016021	integral component of membrane	-	TAS	8938427
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Gene: VAT1

ANCO-SNPs

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)