Gene info: ID 10499

Gene: NCOA2

GENE ID: 10499

Description: nuclear receptor coactivator 2

Gene type: protein-coding

Location: 8q13.3

dbXrefs: Ensembl:ENSG00000140396 MIM:601993 Vega:OTTHUMG00000164671 UniprotKB:Q15596

RefSeq: NC_000008.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.102e-1 (AD) 8.822e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
APPBP2	0.928
SNX13	0.925
FAM199X	0.923
PIKFYVE	0.916
FAM8A1	0.912
KPNA3	0.911
GTF2A1	0.91
ZNF148	0.91
SEC24B	0.91
MAP4K3	0.909

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.593
OR4F29	-0.538
CSAG1	-0.34
NANOGNB	-0.302
AKR1B15	-0.27
TFPI2	-0.264
KLRB1	-0.259
GNG8	-0.251
TNFRSF13B	-0.247
KLRK1	-0.246

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00255	Diethylstilbestrol	Small Molecule	56-53-1	Approved\|Investigational	Target
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Target
DB01645	Genistein	Small Molecule	446-72-0	Investigational	Target
DB02998	Methyltrienolone	Small Molecule	965-93-5	Experimental	Target
DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN	Small Molecule		Experimental	Target
DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol	Small Molecule		Experimental	Target
DB07080	N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule		Experimental	Target
DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule		Experimental	Target
DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule		Experimental	Target
DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	Small Molecule		Experimental	Target
DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	Small Molecule		Experimental	Target
DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small Molecule		Experimental	Target
DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small Molecule		Experimental	Target
DB07863	2-chloro-5-nitro-N-phenylbenzamide	Small Molecule		Experimental	Target
DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate	Small Molecule		Experimental	Target
DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol	Small Molecule		Experimental	Target
DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	Small Molecule		Experimental	Target
DB08175	(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID	Small Molecule		Experimental	Target
DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	Small Molecule		Experimental	Target
DB08398	2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Small Molecule	105650-23-5	Investigational	Target
DB08402	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	Small Molecule		Experimental	Target
DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small Molecule		Experimental	Target
DB08601	tributylstannanyl	Small Molecule		Experimental	Target
DB08773	RALOXIFENE CORE	Small Molecule		Experimental	Target
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Target
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Target
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Target
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Target
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C408047	1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3	"1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3 promotes the reaction [VDR protein mutant form binds to NCOA2 protein]"	16059639
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to NCOA2 protein]"	17962186
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR1 protein binds to NCOA2 protein]"	17603182
C033729	1H,1H,2H,2H-perfluorodecanol	"1H,1H,2H,2H-perfluorodecanol promotes the reaction [ESR2 protein binds to NCOA2 protein]"	17603182
C508406	1H,1H,2H,2H-perfluorooctan-1-ol	"1H,1H,2H,2H-perfluorooctan-1-ol promotes the reaction [ESR1 protein binds to NCOA2 protein]"	17603182
C508406	1H,1H,2H,2H-perfluorooctan-1-ol	"1H,1H,2H,2H-perfluorooctan-1-ol promotes the reaction [ESR2 protein binds to NCOA2 protein]"	17603182
C052102	22,23-dihydroavermectin B(1)a	"22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]"	25257666
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"NCOA2 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of ESR2 protein]"	27634370
C104006	2',3',4',5'-tetrachloro-4-biphenylol	"2',3',4',5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA2 protein]"	10964929
C040488	26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3	"26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 analog promotes the reaction [VDR protein mutant form binds to NCOA2 protein]"	16059639
C014953	2-acetyltributylcitrate	2-acetyltributylcitrate promotes the reaction [NCOA2 protein binds to NR1I2 protein]	21742782
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]"	20160136
C016392	3,3'-diindolylmethane	"ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]"	20160136
C016392	3,3'-diindolylmethane	"NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]"	20160136
C016392	3,3'-diindolylmethane	"NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA]"	20160136
C029435	3-hydroxy-5-cholestenoic acid	3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]	11089551
C041477	3-hydroxyflavone	3-hydroxyflavone promotes the reaction [NCOA2 protein binds to NR1I2 protein]	26238175
C008745	4,4'-bisphenol F	"4,4'-bisphenol F affects the reaction [ESR1 protein binds to NCOA2 protein]"	16546889
C008745	4,4'-bisphenol F	"4,4'-bisphenol F metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]"	16546889
C583074	4,4'-hexafluorisopropylidene diphenol	"NCOA2 protein promotes the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of ESR2 protein]"	27634370
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of NCOA2 mRNA"	27567155
C021287	4-androstene-3,17-diol	"NCOA2 protein promotes the reaction [4-androstene-3,17-diol binds to and results in increased activity of AR protein]"	15336702
C019046	4-phenylphenol	4-phenylphenol affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C019046	4-phenylphenol	4-phenylphenol metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C105260	4-tert-octylphenol	4-tert-octylphenol promotes the reaction [ESR1 protein binds to NCOA2 protein]	10964929
C105260	4-tert-octylphenol	4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA2 protein]	10964929
C559335	9,9-bis(4-hydroxyphenyl)fluorene	"9,9-bis(4-hydroxyphenyl)fluorene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]"	28248286
D000082	Acetaminophen	Acetaminophen results in decreased expression of NCOA2 mRNA	29067470
C016601	afimoxifene	afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]	23583298
C016601	afimoxifene	afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]	28248286
C016601	afimoxifene	benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C016601	afimoxifene	propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of NCOA2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NCOA2 gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of NCOA2 mRNA	21757418
D013196	Dihydrotestosterone	Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]	16648561
D013196	Dihydrotestosterone	methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]	16648561
D013196	Dihydrotestosterone	NCOA2 protein promotes the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]	15336702
D013196	Dihydrotestosterone	NCOA2 protein promotes the reaction [Dihydrotestosterone results in increased expression of AR mRNA]	16877366
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NCOA2 mRNA	16483693
D000735	Androstenedione	NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein]	15336702
D000737	Androstenols	Androstenols inhibits the reaction [NR1I3 protein binds to NCOA2 protein]	17962186
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]	19131511
D001280	Atrazine	Atrazine results in decreased expression of NCOA2 mRNA	26518232
C547126	AZM551248	AZM551248 results in decreased expression of NCOA2 mRNA	22323515
C061004	benidipine	benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NCOA2 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [cobaltous chloride affects the localization of NCOA2 protein]	26350169
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NCOA2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NCOA2 protein	26350169
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NCOA2 mRNA	19770486
C057775	benzylparaben	benzylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D004958	Estradiol	"9,9-bis(4-hydroxyphenyl)fluorene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]"	28248286
D004958	Estradiol	afimoxifene inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein]	28248286
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to H19 gene]]	17962382
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to KLRC1 gene]]	17962382
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to LLGL2 gene]]	17962382
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]	17962382
D004958	Estradiol	ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]	17962382
D004958	Estradiol	ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]]	17962382
D004958	Estradiol	ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]]	17962382
D004958	Estradiol	[Estradiol binds to ESR1 protein] which binds to NCOA2 protein	15123288
D004958	Estradiol	[Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter]	20404318
D004958	Estradiol	[Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to HAVCR2 promoter]	20404318
D004958	Estradiol	[Estradiol binds to ESR2 protein] which binds to NCOA2 protein	15123288
D004958	Estradiol	[Estradiol co-treated with ESR1 protein] results in increased activity of NCOA2 protein	28248286
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]	28807876
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to NCOA2 protein]	10964929\|2366580
D004958	Estradiol	Estradiol promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]	28807876
D004958	Estradiol	Estradiol promotes the reaction [ESR2 protein binds to NCOA2 protein]	10964929
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to IGF1 promoter]	17872375
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to KLRC3 gene]	17395694
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to PTGS2 promoter]	17872375
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to TFF1 promoter]	19838210
D004958	Estradiol	Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B promoter]	20404318
D004958	Estradiol	Estradiol promotes the reaction [TNF protein promotes the reaction [NCOA2 protein binds to IL6 promoter]]	24771768
D004958	Estradiol	Estradiol results in increased expression of NCOA2 protein	16739346
D004958	Estradiol	NCOA2 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]	24771768
D004958	Estradiol	NCOA2 mutant form inhibits the reaction [Estradiol results in increased expression of KRT19 mRNA]	20160136
D004958	Estradiol	NCOA2 mutant form inhibits the reaction [Estradiol results in increased expression of TMEM121B mRNA]	20160136
D004958	Estradiol	NCOA2 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein]	16328721
D004958	Estradiol	Estradiol affects the localization of NCOA2 protein	17556502
D004958	Estradiol	NCOA2 protein inhibits the reaction [ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein]]	27634370
D004958	Estradiol	NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein]	27634370
D004958	Estradiol	NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]	27634370
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to NCOA2 protein]	23583298
D001629	Bezafibrate	Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein]	19263263
C053541	bicalutamide	[IL6 protein results in increased expression of NCOA2 protein] which results in decreased susceptibility to bicalutamide	19240160
C006780	bisphenol A	bisphenol A inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C006780	bisphenol A	bisphenol A promotes the reaction [ESR1 protein binds to NCOA2 protein]	10964929
C006780	bisphenol A	bisphenol A promotes the reaction [ESR2 protein binds to NCOA2 protein]	10964929
C006780	bisphenol A	NCOA2 protein promotes the reaction [bisphenol A results in increased activity of ESR1 protein]	16328721
C006780	bisphenol A	NCOA2 protein promotes the reaction [bisphenol A results in increased expression of ESR2 protein]	27634370
C006780	bisphenol A	bisphenol A affects the expression of NCOA2 mRNA	21786754
C006780	bisphenol A	bisphenol A inhibits the reaction [Genistein results in decreased expression of NCOA2 protein]	24884420
C006780	bisphenol A	bisphenol A results in decreased expression of NCOA2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of NCOA2 protein	19379760\|1959068
C006780	bisphenol A	Genistein inhibits the reaction [bisphenol A results in increased expression of NCOA2 protein]	24884420
C006780	bisphenol A	bisphenol A promotes the reaction [ESR1 protein binds to NCOA2 protein]	23583298
C004605	butamben	butamben promotes the reaction [NR1I2.L protein binds to NCOA2 protein]	12198127
C038091	butylparaben	butylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C018475	butyraldehyde	butyraldehyde results in decreased expression of NCOA2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride promotes the reaction [VDR protein binds to NCOA2 protein]	21229763
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of NCOA2 promoter	22457795
D002635	Chenodeoxycholic Acid	"22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]"	25257666
D002635	Chenodeoxycholic Acid	benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]	27773686
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]	25257666
D002635	Chenodeoxycholic Acid	cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	clevidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D002635	Chenodeoxycholic Acid	Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D002635	Chenodeoxycholic Acid	doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Doxorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Doxorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D002635	Chenodeoxycholic Acid	emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D002635	Chenodeoxycholic Acid	eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	lacidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	milbemycin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002635	Chenodeoxycholic Acid	"pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]"	27773686
D002635	Chenodeoxycholic Acid	selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D002784	Cholesterol	NCOA2 protein affects the metabolism of Cholesterol	14993927
C065927	cilnidipine	cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C019304	ciprofibrate	ciprofibrate inhibits the reaction [NR1I3 protein binds to NCOA2 protein]	17962186
C118563	clevidipine	clevidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C018021	cobaltous chloride	Benzo(a)pyrene inhibits the reaction [cobaltous chloride affects the localization of NCOA2 protein]	26350169
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of NCOA2 protein	26350169
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA]	21370964
D003078	Colchicine	Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D003375	Coumestrol	Coumestrol promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
D003471	Cuprizone	Cuprizone results in decreased expression of NCOA2 mRNA	26577399
D017373	Cyproterone Acetate	[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]	28751236
D017373	Cyproterone Acetate	[Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]	15308689
D017373	Cyproterone Acetate	[Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter]	15308689
C004742	daidzein	daidzein metabolite promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
C004742	daidzein	daidzein promotes the reaction [ESR1 protein binds to NCOA2 protein]	23583298
D003630	Daunorubicin	Daunorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
C036116	desethylamiodarone	desethylamiodarone inhibits the reaction [Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]]	11007966
D003907	Dexamethasone	Dexamethasone results in increased expression of NCOA2 mRNA	19022236
D003907	Dexamethasone	Dexamethasone results in increased expression of NCOA2 mRNA	15557560
C000944	dicrotophos	dicrotophos results in increased expression of NCOA2 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of NCOA2 mRNA	26924002
D004054	Diethylstilbestrol	[Diethylstilbestrol binds to ESR1 protein] which binds to NCOA2 protein	15123288
D004054	Diethylstilbestrol	[Diethylstilbestrol binds to ESR2 protein] which binds to NCOA2 protein	15123288
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA2 protein]	10964929
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA2 protein]	10964929
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of NCOA2 protein	15019724
D002117	Calcitriol	Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter]	19106115
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to VDRALPHA protein]	25279795
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to VDRA protein]	25279795
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to VDRB protein]	25279795
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to VDR protein]	25279795
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to NCOA2 protein]	15578590
D002117	Calcitriol	NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRALPHA protein]]	25279795
D002117	Calcitriol	NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRA protein]]	25279795
D002117	Calcitriol	NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRB protein]]	25279795
D002117	Calcitriol	NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDR protein]]	25279795
D002117	Calcitriol	NCOA2 protein results in increased susceptibility to Calcitriol	25279795
D002117	Calcitriol	RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRALPHA protein]]	25279795
D002117	Calcitriol	RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRA protein]]	25279795
D002117	Calcitriol	RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRB protein]]	25279795
D002117	Calcitriol	RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDR protein]]	25279795
D002117	Calcitriol	Calcitriol affects the localization of NCOA2 protein	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to CYP24A1 promoter]	15647825
D002117	Calcitriol	Calcitriol promotes the reaction [NCOA2 protein binds to SPP1 promoter]	15647825
C118756	dihydroxy-vitamin D3	dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA2 protein modified form]	20947021
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of NCOA2 mRNA	26924002
C004839	dioxybenzone	dioxybenzone affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C004839	dioxybenzone	dioxybenzone metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C084101	doramectin	doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D004317	Doxorubicin	Doxorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D004317	Doxorubicin	Doxorubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal promotes the reaction [NCOA2 protein binds to KRT19 promoter]"	17095596
C547512	eldecalcitol	eldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA2 protein modified form]	20947021
C443359	emamectin	emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C118739	entinostat	entinostat results in decreased expression of NCOA2 mRNA	27188386
D015251	Epirubicin	Epirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]	25257666
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCOA2 mRNA	22079256
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [GW 4064 promotes the reaction [NR1H4 protein binds to NCOA2 protein]]	22178739
C101434	eprinomectin	eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NCOA2 mRNA	20227414
C012313	ethyl-p-hydroxybenzoate	ethyl-p-hydroxybenzoate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C041835	ethyl salicylate	ethyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D015025	Zearalenone	Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]	28807876
D015025	Zearalenone	Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]	28807876
D015025	Zearalenone	Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]	28807876
D015025	Zearalenone	Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]	28807876
D015025	Zearalenone	Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
D015736	Felodipine	Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C070081	fulvestrant	fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]]	24771768
C039281	furan	furan results in increased methylation of NCOA2 gene	22079235
C037032	galangin	galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein]	26238175
C001277	geldanamycin	geldanamycin results in increased expression of NCOA2 mRNA	26705709
D019833	Genistein	[Genistein binds to ESR1 protein] which binds to NCOA2 protein	15123288
D019833	Genistein	[Genistein binds to ESR2 protein] which binds to NCOA2 protein	15123288
D019833	Genistein	Genistein promotes the reaction [ESR1 protein binds to NCOA2 protein]	10964929
D019833	Genistein	Genistein promotes the reaction [ESR2 protein binds to NCOA2 protein]	10964929
D019833	Genistein	Genistein promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
D019833	Genistein	NCOA2 protein promotes the reaction [Genistein results in increased expression of ESR2 protein]	27634370
D019833	Genistein	NCOA2 protein promotes the reaction [Genistein results in increased expression of ESR2 protein alternative form]	27634370
D019833	Genistein	bisphenol A inhibits the reaction [Genistein results in decreased expression of NCOA2 protein]	24884420
D019833	Genistein	Genistein inhibits the reaction [bisphenol A results in increased expression of NCOA2 protein]	24884420
D019833	Genistein	Genistein results in decreased expression of NCOA2 protein	24884420
D019833	Genistein	Genistein promotes the reaction [ESR1 protein binds to NCOA2 protein]	23583298
C412815	GW 4064	epigallocatechin gallate inhibits the reaction [GW 4064 promotes the reaction [NR1H4 protein binds to NCOA2 protein]]	22178739
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to NCOA2 protein]	22178739
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCOA2 mRNA	25613284
D017275	Isradipine	Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D007559	Ivermectin	Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C060285	lacidipine	lacidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C008261	lead acetate	lead acetate promotes the reaction [VDR protein binds to NCOA2 protein]	21229763
C008261	lead acetate	lead acetate results in decreased expression of NCOA2 mRNA	22641619
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of NCOA2 mRNA"	24972896
D008070	Lipopolysaccharides	coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA]	21370964
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NCOA2 mRNA	21370964
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of NCOA2 mRNA	16847310
C502354	lithocholic acid acetate	lithocholic acid acetate inhibits the reaction [NCOA2 protein binds to CYP7A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate inhibits the reaction [NCOA2 protein binds to CYP7A1 promoter]	19106115
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NCOA2 mRNA	21641980
D008713	Methimazole	Methimazole results in increased expression of NCOA2 mRNA	17399805
D008727	Methotrexate	Methotrexate affects the expression of NCOA2 mRNA	18502557
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NCOA2 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NCOA2 mRNA"	20188158
C015358	methylparaben	methylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C033069	methyl salicylate	methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
C008493	methylselenic acid	methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]	16648561
D015741	Metribolone	arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]	19131511
D015741	Metribolone	[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]	28751236
D015741	Metribolone	Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]	19131511
C517398	MF101 extract	MF101 extract promotes the reaction [NCOA2 protein binds to KRT19 promoter]	17095596
D015735	Mifepristone	[Mifepristone binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]	15308689
D015735	Mifepristone	[Mifepristone binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter]	15308689
C027837	milbemycin	milbemycin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of NCOA2 mRNA	26924002
D009529	Nicardipine	Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D009553	Nimodipine	Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D019787	Linoleic Acid	Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein]	19263263
C005290	oxybenzone	oxybenzone affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C005290	oxybenzone	oxybenzone metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
D010100	Oxygen	Oxygen deficiency results in decreased expression of NCOA2 protein	26350169
D010100	Oxygen	Oxygen deficiency affects the methylation of NCOA2 promoter	24205000
D010100	Oxygen	Oxygen deficiency results in increased expression of NCOA2 mRNA	22629407\|2420500
D010100	Oxygen	Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of NCOA2 mRNA]	22629407
C046012	pentanal	pentanal results in decreased expression of NCOA2 mRNA	26079696
C494474	perchlorate	perchlorate results in increased expression of NCOA2 mRNA	17399805
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of NCOA2 mRNA	17560707
D019800	Phenol	Phenol analog affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
D019800	Phenol	Phenol metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
D017905	Phosphites	Phosphites analog affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
D017905	Phosphites	Phosphites metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C006253	pirinixic acid	pirinixic acid promotes the reaction [PPARA protein binds to NCOA2 protein]	19263263
C006253	pirinixic acid	pirinixic acid inhibits the reaction [NR1I3 protein binds to NCOA2 protein]	17962186
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NCOA2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of NCOA2 mRNA	22079256
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]"	27773686
D011374	Progesterone	Progesterone affects the expression of NCOA2 protein	21291521
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of BMP2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of BMP5 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of CALB1 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of CDKL1 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of CLMN mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of DSP mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of EMB mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of HMGA2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of KRT18 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of LDB2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of MPZL2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of POF1B mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of RHPN2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of S100G mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of SLC44A3 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of SOX7 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of TJP3 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of TSPAN8 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of WNT7A mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of ATP2C2 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of CLDN23 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of SLCO5A1 mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of TTR mRNA]	17556502
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in increased expression of TUBB2A mRNA]	17556502
D011374	Progesterone	Progesterone results in increased expression of NCOA2 protein	17556502
C006068	propylparaben	propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]]	23583298
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NCOA2 mRNA	17399805
D011794	Quercetin	Quercetin results in decreased expression of NCOA2 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]	17872375
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to PTGS2 promoter]	17872375
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of NCOA2 protein	16739346
C059514	resveratrol	fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]]	24771768
C059514	resveratrol	NCOA2 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]	24771768
C059514	resveratrol	resveratrol promotes the reaction [NCOA2 protein binds to ESR1 protein]	15084758
C059514	resveratrol	resveratrol promotes the reaction [TNF protein promotes the reaction [NCOA2 protein binds to IL6 promoter]]	24771768
C059514	resveratrol	resveratrol promotes the reaction [ESR1 protein binds to NCOA2 protein]	24771768
C059514	resveratrol	resveratrol promotes the reaction [NCOA2 protein binds to GREB1 gene]	24771768
D012293	Rifampin	Rifampin promotes the reaction [NCOA2 protein binds to HNF4A protein]	21292004
C414354	selamectin	selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]	27773686
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of NCOA2 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of NCOA2 mRNA	19244175
C017947	sodium arsenite	sodium arsenite inhibits the reaction [CARM1 protein binds to NCOA2 protein]	19707557
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NCOA2 mRNA	21641980
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of NCOA2 mRNA"	26680231
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of NCOA2 mRNA	17399805
D014284	Triiodothyronine	desethylamiodarone inhibits the reaction [Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]]	11007966
D014284	Triiodothyronine	Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]	11007966
D013629	Tamoxifen	Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA2 protein]	23665804
D013629	Tamoxifen	Tamoxifen promotes the reaction [NCOA2 protein binds to KLRC3 gene]	17395694
D013629	Tamoxifen	Tamoxifen results in increased expression of NCOA2 mRNA	20332317
D013629	Tamoxifen	Tamoxifen results in increased expression of NCOA2 protein	16739346
C021754	terics	terics metabolite affects the reaction [ESR1 protein binds to NCOA2 protein]	16546889
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of NCOA2 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	NCOA2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	18842620
D013749	Tetrachlorodibenzodioxin	NCOA2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]	18842620
D013749	Tetrachlorodibenzodioxin	NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]	12024042
D013749	Tetrachlorodibenzodioxin	NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	12024042
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1A1 enhancer]	12024042\|1884262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1A1 promoter]	15964790\|1884262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1B1 enhancer]	18842620
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [NCOA2 protein binds to CYP1B1 promoter]	18842620
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NCOA2 mRNA	12377990\|1534536
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NCOA2 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCOA2 mRNA	25613284
D013974	Thyroxine	Thyroxine results in decreased expression of NCOA2 mRNA	17403546
D013974	Thyroxine	Thyroxine results in increased expression of NCOA2 mRNA	17403546
C009495	titanium dioxide	titanium dioxide results in increased expression of NCOA2 mRNA	23557971
D014112	Toxaphene	Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein]	10493499
D014212	Tretinoin	Tretinoin promotes the reaction [RARA protein binds to NCOA2 protein]	15578590
D014212	Tretinoin	Tretinoin affects the reaction [NCOA2 protein binds to NR2C1 promoter]	17389641
C012589	trichostatin A	trichostatin A affects the expression of NCOA2 mRNA	28542535
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of NCOA2 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOA2 mRNA"	23306105
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of NCOA2 mRNA	26562049
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of NCOA2 mRNA	27776230
C057693	troglitazone	troglitazone results in decreased expression of NCOA2 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased expression of NCOA2 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of NCOA2 gene	29154799
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of NCOA2 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of NCOA2 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of NCOA2 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	-	IEA	-
GO:0003682	chromatin binding	-	IEA	-
GO:0003713	transcription coactivator activity	-	ISS	-
GO:0003713	transcription coactivator activity	-	NAS	9430642
GO:0005515	protein binding	-	IPI	11265755 12588987 15563469 17947383 21478865 22504882 24561505
GO:0016922	ligand-dependent nuclear receptor binding	-	IBA	21873635
GO:0016922	ligand-dependent nuclear receptor binding	-	IPI	18798693
GO:0017162	aryl hydrocarbon receptor binding	-	IPI	15641800
GO:0019904	protein domain specific binding	-	IPI	11583620
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	-	IBA	21873635
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	-	IDA	17363140
GO:0030375	thyroid hormone receptor coactivator activity	-	IEA	-
GO:0035257	nuclear hormone receptor binding	-	IBA	21873635
GO:0035257	nuclear hormone receptor binding	-	IPI	10478845
GO:0046983	protein dimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	NAS	8670870
GO:0010906	regulation of glucose metabolic process	-	IEA	-
GO:0015721	bile acid and bile salt transport	-	TAS	-
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0032570	response to progesterone	-	IEA	-
GO:0032870	cellular response to hormone stimulus	-	IBA	21873635
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0045475	locomotor rhythm	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:1904017	cellular response to Thyroglobulin triiodothyronine	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IEA	-
GO:0016604	nuclear body	-	IDA	-
GO:0032991	protein-containing complex	-	IMP	15641800

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1368082	RORA activates gene expression	TAS
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-159418	Recycling of bile acids and salts	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-192105	Synthesis of bile acids and bile salts	TAS
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	TAS
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	TAS
R-HSA-194068	Bile acid and bile salt metabolism	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-1989781	PPARA activates gene expression	IEA
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211976	Endogenous sterols	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-3214847	HATs acetylate histones	TAS
R-HSA-3247509	Chromatin modifying enzymes	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	IEA
R-HSA-400253	Circadian Clock	TAS
R-HSA-400253	Circadian Clock	IEA
R-HSA-4839726	Chromatin organization	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-5625740	RHO GTPases activate PKNs	TAS
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8957322	Metabolism of steroids	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23144319	Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (2013 Feb)	Lee Y	Carcinogenesis