Gene: SEMA6B

10501
SEM-SEMA-Y|SEMA-VIB|SEMAN|semaZ
semaphorin 6B
protein-coding
19p13.3
Ensembl:ENSG00000167680 MIM:608873 Vega:OTTHUMG00000182011 UniprotKB:Q9H3T3
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.520e-1 (AD)  4.950e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP40.958
FBXL190.95
NRXN20.946
PPP6R10.945
PIK3R20.942
GRIK50.938
DGKZ0.937
NACC10.937
DLG40.937
MAP3K100.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.658
OR4F29-0.601
SEPT10-0.432
CTNNA3-0.407
HBD-0.404
REST-0.404
VNN2-0.401
VRK2-0.396
SGMS2-0.393
RAI14-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SEMA6B mRNA"23146750
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SEMA6B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA6B mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SEMA6B mRNA17562736
C103303alitretinoinalitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]16525649
C103303alitretinoinalitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein]16525649
C103303alitretinoinalitretinoin promotes the reaction [troglitazone results in decreased expression of SEMA6B mRNA]16525649
C103303alitretinoinalitretinoin promotes the reaction [troglitazone results in decreased expression of SEMA6B protein]16525649
D000638AmiodaroneAmiodarone results in increased expression of SEMA6B mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SEMA6B mRNA16483693
D001280AtrazineAtrazine results in increased expression of SEMA6B mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene results in increased expression of SEMA6B mRNA]20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEMA6B mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEMA6B mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of SEMA6B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SEMA6B mRNA26472689
D003042CocaineCocaine results in increased expression of SEMA6B mRNA15691709
D002945CisplatinCisplatin results in decreased expression of SEMA6B mRNA27392435
D011345Fenofibratealitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]16525649
D011345Fenofibratealitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein]16525649
D011345FenofibrateFenofibrate results in decreased expression of SEMA6B mRNA16525649
D011345FenofibrateFenofibrate results in decreased expression of SEMA6B protein16525649
C492448ICG 001ICG 001 results in increased expression of SEMA6B mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SEMA6B mRNA24796395|2675264
D007854LeadLead affects the expression of SEMA6B mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SEMA6B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SEMA6B mRNA"25554681|2562005
C029938nickel sulfatenickel sulfate results in increased expression of SEMA6B mRNA22714537
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SEMA6B mRNA"21673326
C046012pentanalpentanal results in increased expression of SEMA6B mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEMA6B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SEMA6B mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SEMA6B mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of SEMA6B mRNA26079696
D053260SootSoot results in increased expression of SEMA6B mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SEMA6B mRNA20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEMA6B mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of SEMA6B mRNA27760801
C057693troglitazonealitretinoin promotes the reaction [troglitazone results in decreased expression of SEMA6B mRNA]16525649
C057693troglitazonealitretinoin promotes the reaction [troglitazone results in decreased expression of SEMA6B protein]16525649
C057693troglitazonetroglitazone results in decreased expression of SEMA6B mRNA16525649
C057693troglitazonetroglitazone results in decreased expression of SEMA6B protein16525649
D014635Valproic AcidValproic Acid results in increased methylation of SEMA6B gene29154799
D019287Zinc SulfateZinc Sulfate results in increased expression of SEMA6B mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030215semaphorin receptor binding-IBA21873635  
GO:0030215semaphorin receptor binding-IEA-  
GO:0045499chemorepellent activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001755neural crest cell migration-IBA21873635  
GO:0007399nervous system development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0048843negative regulation of axon extension involved in axon guidance-IBA21873635  
GO:0050919negative chemotaxis-IBA21873635  
GO:0071526semaphorin-plexin signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29808722RNA-Sequencing to Predict Response to TNF-alpha inhibitors Reveals Possible Mechanism for Non-response in Smokers. (2018 May 29)Cuppen BVJExpert Rev Clin Immunol