Gene: FBLN5

10516
ADCL2|ARCL1A|ARMD3|DANCE|EVEC|FIBL-5|HNARMD|UP50
fibulin 5
protein-coding
14q32.12
Ensembl:ENSG00000140092 MIM:604580 Vega:OTTHUMG00000171122 UniprotKB:Q9UBX5
NG_008254.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.311e-1 (AD)  5.403e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITIH30.775
NEXN0.773
TAGLN0.767
AOC30.755
PRSS230.737
ACTA20.733
PLN0.725
COL8A10.715
SERPIND10.713
VCL0.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPSE2-0.366
BTBD17-0.336
PYGM-0.333
HES6-0.33
NXNL1-0.31
REN-0.31
ZNF98-0.307
RLBP1-0.296
ARSF-0.289
WNT7B-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of FBLN5 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FBLN5 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FBLN5 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of FBLN5 mRNA"23829299
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of FBLN5 mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FBLN5 mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FBLN5 mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FBLN5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FBLN5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FBLN5 gene27153756
D000447AldehydesAldehydes results in increased expression of FBLN5 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FBLN5 mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of FBLN5 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of FBLN5 mRNA23912714
C006632arsenic trioxidearsenic trioxide results in increased expression of FBLN5 mRNA15761015
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN5 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FBLN5 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FBLN5 mRNA22610609
C006780bisphenol Abisphenol A affects the expression of FBLN5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FBLN5 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of FBLN5 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of FBLN5 mRNA20977926
C018475butyraldehydebutyraldehyde results in increased expression of FBLN5 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FBLN5 mRNA26314618
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FBLN5 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FBLN5 mRNA17484886
D002330CarmustineCarmustine results in decreased expression of FBLN5 mRNA16005536
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of FBLN5 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of FBLN5 mRNA24386269
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA22276220
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein22276220
D003471CuprizoneCuprizone results in increased expression of FBLN5 mRNA26577399|2752363
D000069439DasatinibDasatinib results in increased expression of FBLN5 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of FBLN5 mRNA25056791
C016366dibenzothiophenedibenzothiophene results in decreased expression of FBLN5 mRNA23656968
D002945CisplatinCisplatin results in increased expression of FBLN5 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN5 mRNA18164116
C118739entinostatentinostat results in increased expression of FBLN5 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FBLN5 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FBLN5 mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FBLN5 mRNA15576828
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA20938992
C039281furanfuran results in increased expression of FBLN5 mRNA27387713
C010176halofuginonehalofuginone results in increased expression of FBLN5 mRNA17180598
D007854LeadLead affects the expression of FBLN5 mRNA28903495
C533894LG 100815LG 100815 results in increased expression of FBLN5 mRNA16951191
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of FBLN5 mRNA16005536
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FBLN5 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FBLN5 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FBLN5 mRNA"25554681|2562005
C022838nickel chloridenickel chloride affects the expression of FBLN5 mRNA22110744
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of FBLN5 mRNA"16951191
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FBLN5 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of FBLN5 mRNA26516004
C410127PCB 180PCB 180 results in increased expression of FBLN5 mRNA23829299
C046012pentanalpentanal results in increased expression of FBLN5 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FBLN5 mRNA26272509
D010705PhosgenePhosgene affects the expression of FBLN5 mRNA16300373
D011192Potassium DichromatePotassium Dichromate results in increased expression of FBLN5 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of FBLN5 mRNA21795739
C005556propionaldehydepropionaldehyde results in increased expression of FBLN5 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of FBLN5 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FBLN5 mRNA27029645
C502851quinocetonequinocetone results in increased expression of FBLN5 mRNA27046791
C059514resveratrolresveratrol results in increased expression of FBLN5 mRNA25888808
D012643SeleniumSelenium results in increased expression of FBLN5 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FBLN5 mRNA25895662
D012834SilverSilver results in decreased expression of FBLN5 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of FBLN5 gene28589171
D012999SomanSoman results in increased expression of FBLN5 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of FBLN5 mRNA17555576
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA22276220
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein22276220
D013866ThioguanineThioguanine results in decreased expression of FBLN5 mRNA16005536
C009495titanium dioxidetitanium dioxide results in decreased expression of FBLN5 mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FBLN5 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FBLN5 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FBLN5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FBLN5 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of FBLN5 mRNA28973697
D014520UrethaneUrethane results in decreased expression of FBLN5 mRNA16289808
D014635Valproic AcidValproic Acid results in increased expression of FBLN5 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of FBLN5 gene29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of FBLN5 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of FBLN5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-ISS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI15790312  17035250  17581631  19570982  25118846  25910212  
GO:0008022protein C-terminus binding-IPI15528465  
GO:0042803protein homodimerization activity-IDA19617354  20007835  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0007160cell-matrix adhesion-TAS10428823  
GO:0030198extracellular matrix organization-TAS-  
GO:0034394protein localization to cell surface-ISS-  
GO:0046903secretion-IDA20599547  
GO:0048251elastic fiber assembly-IMP17035250  
GO:0048251elastic fiber assembly-ISS-  
GO:2000121regulation of removal of superoxide radicals-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0031012extracellular matrix-IDA17035250  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA23533145  
GO:0071953elastic fibercolocalizes_withISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation
20301756FBLN5-Related Cutis Laxa (1993)Van Maldergem L-