Gene: DEAF1

10522
MRD24|NUDR|SPN|ZMYND5
DEAF1, transcription factor
protein-coding
11p15.5
Ensembl:ENSG00000177030 MIM:602635 Vega:OTTHUMG00000165363 UniprotKB:O75398
NG_034156.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.896e-1 (AD)  4.994e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AES0.926
SGSM20.924
ST6GALNAC60.915
BTBD20.913
NSMF0.912
PSD0.912
CA110.91
UBXN60.91
WDR130.909
NELFB0.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.785
OR4F29-0.744
CXCL3-0.318
KCNJ15-0.316
CLEC2B-0.305
CCDC36-0.298
ANGPT2-0.296
TFPI2-0.293
SHISA3-0.287
IL6-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DEAF1 mRNA17562736
C044887beta-methylcholinebeta-methylcholine affects the expression of DEAF1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DEAF1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of DEAF1 mRNA20977926
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNA20360939
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DEAF1 mRNA28472532
D003042CocaineCocaine results in decreased expression of DEAF1 mRNA15009677|1671032
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DEAF1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of DEAF1 mRNA19549813
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DEAF1 mRNA19684285
D003520CyclophosphamideCyclophosphamide results in decreased expression of DEAF1 mRNA27281708
D016572CyclosporineCyclosporine results in decreased expression of DEAF1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DEAF1 mRNA]27941970
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNA20360939
D003932HeroinHeroin results in decreased expression of DEAF1 mRNA16710320
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of DEAF1 protein17337753
D008694MethamphetamineMethamphetamine results in increased expression of DEAF1 mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DEAF1 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of DEAF1 mRNA12634122
C008493methylselenic acidmethylselenic acid results in decreased expression of DEAF1 mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DEAF1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of DEAF1 mRNA16780908
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DEAF1 mRNA20971185
C010313pseudocumenepseudocumene results in decreased expression of DEAF1 protein17337753
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of DEAF1 mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of DEAF1 mRNA21427059
D012999SomanSoman results in decreased expression of DEAF1 mRNA19281266
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of DEAF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DEAF1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DEAF1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DEAF1 mRNA21215274
C022884undecaneundecane results in decreased expression of DEAF1 protein17337753
D014635Valproic AcidValproic Acid results in increased methylation of DEAF1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of DEAF1 mRNA19136453|2142705
D014635Valproic AcidValproic Acid results in increased expression of DEAF1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA24726472  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA24726472  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI20368287  21988832  22442688  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA24726472  
GO:0001662behavioral fear response-IEA-  
GO:0001843neural tube closure-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007281germ cell development-TAS9773984  
GO:0008542visual learning-IEA-  
GO:0009653anatomical structure morphogenesis-TAS9773984  
GO:0033599regulation of mammary gland epithelial cell proliferation-IDA18826651  
GO:0045892negative regulation of transcription, DNA-templated-IDA24726472  
GO:0045893positive regulation of transcription, DNA-templated-IDA24726472  
GO:0048706embryonic skeletal system development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005667transcription factor complex-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29691085The SMYD3 VNTR 3/3 polymorphism confers an increased risk and poor prognosis of hepatocellular carcinoma in a Chinese population. (2018 May)Li RDPathol Res Pract