Gene: KAT5

10524
ESA1|HTATIP|HTATIP1|PLIP|TIP|TIP60|ZC2HC5|cPLA2
lysine acetyltransferase 5
protein-coding
11q13.1
Ensembl:ENSG00000172977 MIM:601409 Vega:OTTHUMG00000166617 UniprotKB:Q92993
NG_033057.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.692e-1 (AD)  4.813e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD20.951
DHX300.947
CHMP70.942
PSMD30.939
IDH3B0.938
PPP5C0.938
DCTN20.938
ABCF30.937
PFKM0.936
USP50.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.632
MTRNR2L9-0.414
MTRNR2L6-0.414
MTRNR2L10-0.396
CST7-0.344
KLRB1-0.333
IL18RAP-0.333
S100A12-0.333
FMO3-0.33

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01992Coenzyme ASmall Molecule85-61-0Investigational|NutraceuticalTarget
DB02039S-Acetyl-CysteineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KAT5 mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to KAT5 protein28837777
C0326424-aminophenylarsenoxidesodium arsenite inhibits the reaction [4-aminophenylarsenoxide binds to KAT5 protein]28837777
C0326424-aminophenylarsenoxidezinc chloride affects the reaction [4-aminophenylarsenoxide binds to KAT5 protein]28837777
D000082AcetaminophenAcetaminophen affects the expression of KAT5 mRNA17562736
C006632arsenic trioxidearsenic trioxide results in decreased expression of KAT5 mRNA19763917
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of KAT5 mRNA"17331233
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KAT5 protein results in increased acetylation of and results in increased degradation of SRSF2 protein]21157427
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of KAT5 protein]28837777
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KAT5 protein28837777
D004958EstradiolEstradiol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]23857583
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT5 protein modified form]28751236
C006780bisphenol Abisphenol A inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]23857583
C006780bisphenol Abisphenol A results in increased expression of KAT5 mRNA28196854
C006780bisphenol Abisphenol A affects the expression of KAT5 mRNA25181051
D020148Butyric AcidButyric Acid promotes the reaction [KAT5 protein results in increased acetylation of SRSF2 protein]21555914
D020148Butyric AcidButyric Acid promotes the reaction [SRSF2 protein binds to KAT5 protein]21555914
D020148Butyric AcidButyric Acid results in increased expression of KAT5 mRNA21555914
D020148Butyric AcidButyric Acid results in increased expression of KAT5 protein21555914
D020148Butyric AcidKAT5 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]21555914
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KAT5 mRNA23741332
D016572CyclosporineCyclosporine results in increased expression of KAT5 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of KAT5 mRNA24921660
C089595cylindrospermopsincylindrospermopsin results in increased expression of KAT5 protein24921660
C004742daidzeindaidzein inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]23857583
C014347decitabinedecitabine results in increased expression of KAT5 mRNA17908484
C492519diarylpropionitrilediarylpropionitrile inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]23857583
C492519diarylpropionitrilediarylpropionitrile inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]23857583
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KAT5 mRNA17361019
D002945CisplatinCisplatin results in decreased expression of KAT5 mRNA21157427
D002945CisplatinCisplatin results in decreased expression of KAT5 protein21157427
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KAT5 mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KAT5 mRNA22079256
D060754EquolEquol inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]23857583
D060754EquolEquol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]23857583
D019833GenisteinGenistein inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]23857583
D019833GenisteinGenistein inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]23857583
D017313FenretinideFenretinide results in increased expression of KAT5 mRNA28973697
D008777MethyltestosteroneMethyltestosterone results in decreased expression of KAT5 mRNA29191790
D010419PentamidinePentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]20144237
D010419PentamidinePentamidine results in decreased activity of KAT5 protein20144237
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KAT5 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KAT5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KAT5 mRNA22079256
C059514resveratrolresveratrol results in increased acetylation of KAT5 protein25533949
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of KAT5 mRNA21427059
D012524SarinSarin results in decreased expression of KAT5 mRNA19522546
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of KAT5 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of KAT5 mRNA29191790
C017947sodium arsenitebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of KAT5 protein]28837777
C017947sodium arsenitesodium arsenite affects the methylation of KAT5 gene28589171
C017947sodium arsenitesodium arsenite binds to and results in decreased expression of KAT5 protein28837777
C017947sodium arsenitesodium arsenite inhibits the reaction [4-aminophenylarsenoxide binds to KAT5 protein]28837777
C061133tamibarotenetamibarotene results in increased expression of KAT5 mRNA15498508
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of KAT5 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KAT5 mRNA21570461
D014212TretinoinTretinoin results in increased expression of KAT5 mRNA15498508
C012589trichostatin Atrichostatin A results in decreased expression of KAT5 mRNA24935251|2854253
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KAT5 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of KAT5 mRNA22083351|2493525
D014635Valproic AcidValproic Acid results in decreased expression of KAT5 mRNA21427059
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of KAT5 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of KAT5 mRNA22083351
C016837zinc chloridezinc chloride affects the reaction [4-aminophenylarsenoxide binds to KAT5 protein]28837777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA14966270  
GO:0003713transcription coactivator activity-TAS17360565  
GO:0004402histone acetyltransferase activity-IBA21873635  
GO:0004402histone acetyltransferase activity-IDA18397884  
GO:0004402histone acetyltransferase activitycontributes_toIDA14966270  
GO:0004402histone acetyltransferase activity-IMP17996965  
GO:0005515protein binding-IPI10364196  10966108  15383276  15647280  16169070  16230350  
17110330  17360565  17996965  18087039  18397884  18451177  
18485870  18509338  19909775  21157427  21699783  21936881  
21988832  22081016  22094252  24525235  25245946  25416956  
26829474  27107012  
GO:0010485H4 histone acetyltransferase activity-IBA21873635  
GO:0016407acetyltransferase activity-TAS-  
GO:0042393histone binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0050681androgen receptor binding-NAS15572661  
GO:0070491repressing transcription factor binding-IPI17360565  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP17360565  
GO:0000729DNA double-strand break processing-TAS-  
GO:0006260DNA replication-TAS-  
GO:0006302double-strand break repair-IMP10966108  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-IDA14966270  
GO:0010212response to ionizing radiation-IDA18397884  
GO:0016032viral process-IEA-  
GO:0016573histone acetylation-IDA10966108  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0032703negative regulation of interleukin-2 production-IDA17360565  
GO:0040008regulation of growth-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP18397884  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IDA17360565  
GO:0045893positive regulation of transcription, DNA-templated-IDA14966270  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP23637611  
GO:0071392cellular response to estradiol stimulus-IDA23637611  
GO:1901985positive regulation of protein acetylation-IDA24012345  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IBA21873635  
GO:0000790nuclear chromatin-IBA21873635  
GO:0000812Swr1 complex-IDA24463511  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17996965  24012345  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005730nucleolus-IDA16387653  
GO:0032777Piccolo NuA4 histone acetyltransferase complex-IBA21873635  
GO:0032777Piccolo NuA4 histone acetyltransferase complex-IDA14966270  
GO:0035267NuA4 histone acetyltransferase complex-IDA10966108  14966270  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-4839726Chromatin organizationIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693548Sensing of DNA Double Strand BreaksTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26300722Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. (2015)Finegersh AFront Mol Neurosci