Gene: PITRM1

10531
MP1|PreP
pitrilysin metallopeptidase 1
protein-coding
10p15.2
Ensembl:ENSG00000107959 Vega:OTTHUMG00000017557 UniprotKB:Q5JRX3
NG_052908.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
7.384e-1 (AD)  8.669e-1 (ND)   (Frontal_Cortex)
2.000e-1 (AD)  2.770e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7097793chr10:3144751 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GBA20.93
EXOC70.928
VPS390.925
AP2B10.925
KIAA0319L0.923
SPTAN10.923
CS0.923
AP3D10.922
DEF80.921
COPA0.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.707
OR4F29-0.673
MTRNR2L6-0.321
MTRNR2L10-0.315
MTRNR2L9-0.305
TFPI2-0.291
KLRB1-0.29
ARHGEF35-0.27
SH2D1A-0.269
PPBP-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PITRM1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of PITRM1 mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of PITRM1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PITRM1 mRNA28959563
C447119bazedoxifenebazedoxifene results in increased expression of PITRM1 mRNA19914376
C006780bisphenol Abisphenol A affects the expression of PITRM1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PITRM1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PITRM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PITRM1 mRNA26794494
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PITRM1 mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of PITRM1 protein28903499
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PITRM1 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PITRM1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of PITRM1 mRNA24612858
D019327Copper SulfateCopper Sulfate results in increased expression of PITRM1 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of PITRM1 protein26984711
D016572CyclosporineCyclosporine results in increased expression of PITRM1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of PITRM1 promoter27989131
C014347decitabinedecitabine results in increased expression of PITRM1 mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PITRM1 mRNA15251184
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PITRM1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PITRM1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PITRM1 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of PITRM1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PITRM1 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PITRM1 mRNA17475347
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PITRM1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PITRM1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of PITRM1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of PITRM1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PITRM1 mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PITRM1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PITRM1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PITRM1 mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PITRM1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PITRM1 protein25809596
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PITRM1 mRNA26011545
D015735MifepristoneMifepristone results in decreased expression of PITRM1 mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PITRM1 mRNA26924002
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PITRM1 protein26879310
C009277sodium arsenatesodium arsenate results in increased expression of PITRM1 mRNA23922661
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PITRM1 mRNA15251184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PITRM1 mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PITRM1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PITRM1 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of PITRM1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PITRM1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PITRM1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PITRM1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PITRM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IDA10360838  19196155  
GO:0004222metalloendopeptidase activity-IMP16849325  24931469  
GO:0008047enzyme activator activity-TAS9733512  
GO:0008237metallopeptidase activity-EXP19962426  26697887  
GO:0008270zinc ion binding-IDA24931469  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA10360838  19196155  
GO:0006508proteolysis-IMP16849325  24931469  
GO:0006626protein targeting to mitochondrion-TAS-  
GO:0043085positive regulation of catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-IDA16849325  19196155  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29216386An exome-wide association study identifies new susceptibility loci for age of smoking initiation in African- and European-American populations. (2017 Dec 5)Jiang KNicotine Tob Res