Gene: DCTN2

10540
DCTN50|DYNAMITIN|HEL-S-77|RBP50
dynactin subunit 2
protein-coding
12q13.3
Ensembl:ENSG00000175203 MIM:607376 Vega:OTTHUMG00000170124 UniprotKB:Q13561
NG_047120.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.949e-1 (AD)  4.685e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1148552chr12:57549189 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs703841chr12:57548522 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs775238chr12:57544298 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDH3B0.976
AP2M10.975
ATP6V1E10.973
MDH20.972
PITHD10.968
YWHAB0.968
MKRN10.968
ATXN100.968
SAE10.967
UQCRC20.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.724
OR4F29-0.688
MTRNR2L6-0.378
MTRNR2L9-0.359
MTRNR2L10-0.354
S100A12-0.333
CST7-0.328
CXCR2-0.325
KCNJ15-0.324
VNN3-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DCTN2 mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of DCTN2 protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DCTN2 protein26072098
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCTN2 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of DCTN2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DCTN2 mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of DCTN2 mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DCTN2 mRNA23650126
D016572CyclosporineCyclosporine results in increased expression of DCTN2 mRNA20106945|2556210
D004026DieldrinDieldrin results in increased expression of DCTN2 protein20584760
D004317DoxorubicinDoxorubicin affects the expression of DCTN2 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DCTN2 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DCTN2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DCTN2 mRNA16467188|1794274
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in decreased expression of DCTN2 protein24239914
C051890irinotecanirinotecan analog results in increased expression of DCTN2 mRNA18927307
D007854LeadLead results in decreased expression of DCTN2 mRNA19921347
D008148LovastatinLovastatin results in decreased expression of DCTN2 mRNA20493250
D008353MannitolMannitol results in increased expression of DCTN2 mRNA25270620
D008731MethoxychlorMethoxychlor results in increased methylation of DCTN2 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DCTN2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DCTN2 mRNA29191790
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DCTN2 protein25616259
D010416PentachlorophenolPentachlorophenol results in increased expression of DCTN2 mRNA23892564
D012524SarinSarin results in increased expression of DCTN2 protein28973502
D012715Sesame OilSesame Oil results in increased expression of DCTN2 mRNA29191790
D013629TamoxifenTamoxifen affects the expression of DCTN2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DCTN2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCTN2 mRNA16467188
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of DCTN2 protein20109541
D014859WarfarinWarfarin results in decreased expression of DCTN2 mRNA20493250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-IEA-  
GO:0005515protein binding-IPI10226031  16189514  17043677  17139249  17500595  20978158  
21988832  23414759  25416956  26496610  26638075  26950892  
27107012  27173435  
GO:0019901protein kinase binding-IPI17139249  
GO:0030507spectrin binding-IDA23704327  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000278mitotic cell cycle-IMP8647893  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007052mitotic spindle organization-IBA21873635  
GO:0008283cell proliferation-IMP8647893  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0032402melanosome transport-IEA-  
GO:0071539protein localization to centrosome-IMP24816561  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA8647893  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA8647893  21399614  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005869dynactin complex-IBA21873635  
GO:0005869dynactin complex-IDA8647893  
GO:0005874microtubule-IEA-  
GO:0016020membrane-IEA-  
GO:0030286dynein complex-IEA-  
GO:0030426growth cone-IEA-  
GO:0031982vesicle-IDA20682791  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)TAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal