Gene: AGPAT1

10554
1-AGPAT1|G15|LPAAT-alpha|LPAATA
1-acylglycerol-3-phosphate O-acyltransferase 1
protein-coding
6p21.32
Ensembl:ENSG00000204310 MIM:603099 Vega:OTTHUMG00000031210 UniprotKB:Q99943
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDIPT0.954
GDI10.952
RAB1B0.949
PKM0.949
GRINA0.941
RNF1670.941
OTUD50.94
AP3D10.939
RIC8A0.937
DEF80.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.8
OR4F29-0.771
TFPI2-0.349
IL18RAP-0.345
KCNJ15-0.318
CEACAM3-0.313
CST7-0.311
KLRB1-0.306
CXCR2-0.303
CLEC12A-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AGPAT1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AGPAT1 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of AGPAT1 mRNA"28433925
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AGPAT1 mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of AGPAT1 mRNA20146248
D000082AcetaminophenAcetaminophen affects the expression of AGPAT1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AGPAT1 mRNA24449571
D001151ArsenicArsenic affects the methylation of AGPAT1 gene25304211
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of AGPAT1 mRNA20146248
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGPAT1 mRNA20106945
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of AGPAT1 mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of AGPAT1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPAT1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AGPAT1 mRNA15003993
C028031cadmium acetatecadmium acetate results in increased expression of AGPAT1 mRNA12965115
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of AGPAT1 promoter22457795
C026690cerous chloridecerous chloride results in decreased expression of AGPAT1 mRNA23573234
D003024ClozapineClozapine results in decreased expression of AGPAT1 mRNA14647396
C018021cobaltous chloridecobaltous chloride results in decreased expression of AGPAT1 mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of AGPAT1 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPAT1 mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of AGPAT1 mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of AGPAT1 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of AGPAT1 mRNA25016146
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of AGPAT1 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of AGPAT1 mRNA"28433925
D000431EthanolEthanol results in decreased expression of AGPAT1 mRNA28069986
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of AGPAT1 mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of AGPAT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of AGPAT1 mRNA]"23333450
D006220HaloperidolHaloperidol results in decreased expression of AGPAT1 mRNA14647396
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPAT1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AGPAT1 mRNA28628672
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AGPAT1 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of AGPAT1 mRNA19159669
D010936Plant ExtractsPlant Extracts results in decreased expression of AGPAT1 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGPAT1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGPAT1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of AGPAT1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AGPAT1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AGPAT1 mRNA28213091|2823826
D013849ThimerosalThimerosal results in decreased expression of AGPAT1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of AGPAT1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of AGPAT1 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased methylation of AGPAT1 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AGPAT1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of AGPAT1 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of AGPAT1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of AGPAT1 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of AGPAT1 mRNA23034163
C025643vinclozolinvinclozolin results in increased methylation of AGPAT1 promoter22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-IBA21873635  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-IGI9212163  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001819positive regulation of cytokine production-IMP9212163  
GO:0001961positive regulation of cytokine-mediated signaling pathway-IC9212163  
GO:0006644phospholipid metabolic process-TAS9212163  
GO:0006654phosphatidic acid biosynthetic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-IGI9212163  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0016024CDP-diacylglycerol biosynthetic process-IEA-  
GO:0031325positive regulation of cellular metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163765ChREBP activates metabolic gene expressionTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27909437Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study. (2016)Svendsen AJFront Immunol