Gene: RPP30

10556
TSG15
ribonuclease P/MRP subunit p30
protein-coding
10q23.31
Ensembl:ENSG00000148688 MIM:606115 Vega:OTTHUMG00000018733 UniprotKB:P78346
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.923e-2 (AD)  9.592e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4933618chr10:90892814 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TDP20.917
DRG10.913
SSB0.905
CCT80.905
API50.903
MBNL20.899
CSE1L0.898
PPHLN10.897
MPHOSPH100.896
CSTF10.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.595
KLRB1-0.305
ZBTB20-0.272
MTRNR2L10-0.267
TIGIT-0.257
MTRNR2L6-0.252
MTRNR2L9-0.251
KCNK5-0.249
ASB4-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RPP30 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of RPP30 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RPP30 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RPP30 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RPP30 mRNA24449571
D001280AtrazineAtrazine results in increased expression of RPP30 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPP30 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of RPP30 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of RPP30 mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RPP30 mRNA28472532
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RPP30 mRNA17361019
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPP30 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RPP30 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of RPP30 mRNA23649840
C016517indole-3-carbinolindole-3-carbinol affects the expression of RPP30 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPP30 mRNA25613284
C410337K 7174K 7174 results in decreased expression of RPP30 mRNA24086573
C008261lead acetatelead acetate results in increased expression of RPP30 mRNA21829687
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RPP30 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPP30 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPP30 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RPP30 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RPP30 mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of RPP30 mRNA22124623
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RPP30 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RPP30 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of RPP30 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPP30 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPP30 mRNA17942748
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of RPP30 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPP30 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPP30 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of RPP30 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RPP30 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RPP30 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RPP30 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of RPP30 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RPP30 mRNA24383497
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RPP30 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003723RNA binding-IBA21873635  
GO:0004526ribonuclease P activityCONTRIBUTES_TOIBA21873635  
GO:0004526ribonuclease P activitycontributes_toIDA16723659  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001682tRNA 5'-leader removal-IDA16723659  
GO:0008033tRNA processing-IBA21873635  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000172ribonuclease MRP complex-IDA16723659  
GO:0005634nucleus-TAS9630247  
GO:0005654nucleoplasm-TAS-  
GO:0005655nucleolar ribonuclease P complex-IBA21873635  
GO:0005655nucleolar ribonuclease P complex-TAS9630247  
GO:0030681multimeric ribonuclease P complex-IDA16723659  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-6784531tRNA processing in the nucleusTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72306tRNA processingTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal