Gene: CEL

1056
BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8
carboxyl ester lipase
protein-coding
9q34.13
Ensembl:ENSG00000170835 MIM:114840 Vega:OTTHUMG00000020855 UniprotKB:P19835
NG_016394.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.254e-1 (AD)  5.303e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELA2A0.854
GP20.833
CELA3B0.83
PNLIPRP10.825
CTRB10.823
CTRC0.816
CPB10.805
SYCN0.805
PLA2G1B0.801
CELA3A0.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2L2-0.293
STARD6-0.292
CCT6B-0.289
SOX3-0.257
MYH15-0.251
CDNF-0.25
RBM3-0.248
DPH6-0.245
KRBOX1-0.236
G6PC2-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CEL mRNA"23146750
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CEL mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CEL mRNA"23146750
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of CEL mRNA19643169
C0925612-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide"2-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide results in decreased activity of CEL protein"16449251
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CEL mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
C0086424-nitrophenyl acetateCEL protein affects the metabolism of 4-nitrophenyl acetate11592731
C0415944-nonylphenol4-nonylphenol results in increased expression of CEL mRNA17912697
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CEL mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CEL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CEL mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CEL protein21527772
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CEL mRNA16483693
D001151ArsenicArsenic affects the expression of CEL mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEL mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of CEL mRNA17912697
C006780bisphenol Abisphenol A results in decreased expression of CEL mRNA23146750
C006780bisphenol Abisphenol A affects the expression of CEL mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CEL mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CEL mRNA18213484
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CEL mRNA18804290
D002136Calcium, Dietary"[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA"15539406
D000074262Canola OilCanola Oil affects the expression of CEL mRNA16177195
C026690cerous chloridecerous chloride results in increased expression of CEL mRNA23139204
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CEL mRNA26272509
D003042CocaineCocaine results in increased expression of CEL mRNA27899881
C029892cupric chloridecupric chloride results in decreased expression of CEL mRNA24650576
D003520CyclophosphamideCyclophosphamide results in increased expression of CEL mRNA21527772
D003609DactinomycinDactinomycin results in increased expression of CEL mRNA21527772
C000912diazoxondiazoxon results in decreased activity of CEL protein16449251
D002945CisplatinCisplatin results in decreased expression of CEL mRNA27594783
D004006DichlorvosDichlorvos analog results in decreased activity of CEL protein16449251
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CEL mRNA26924002
D002117CalcitriolCalcitriol results in decreased expression of CEL mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CEL mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CEL mRNA17912697
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CEL mRNA23550701
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CEL mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CEL mRNA23649840
C100419ethyl octylphosphonofluoridateethyl octylphosphonofluoridate results in decreased activity of CEL protein16449251
D005047EtoposideEtoposide results in increased expression of CEL mRNA21527772
D005278FenitrothionFenitrothion analog results in decreased activity of CEL protein16449251
D005419FlavonoidsFlavonoids results in increased expression of CEL mRNA18035473
D005419FlavonoidsFlavonoids results in decreased activity of CEL protein23643881
D005557FormaldehydeFormaldehyde results in increased expression of CEL mRNA23649840
D006418Heme"[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA"15539406
D006418HemeHeme results in decreased expression of CEL mRNA15539406
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CEL mRNA17183730
C051890irinotecanCEL protein results in increased susceptibility to irinotecan9766666
D007501IronIron deficiency results in increased expression of CEL mRNA19821111
C008261lead acetatelead acetate results in increased expression of CEL mRNA20542052
C005219methyl cellosolvemethyl cellosolve results in increased expression of CEL mRNA19643169
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CEL mRNA21527772|2364984
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CEL mRNA15240709
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CEL mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of CEL mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CEL mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CEL mRNA"25620056
D000069463Olive OilOlive Oil analog affects the expression of CEL mRNA17349074
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate analog results in decreased activity of CEL protein"16449251
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of CEL protein"16449251
C055122orlistatorlistat results in decreased activity of CEL protein11592731|1238133
D010261ParaoxonParaoxon results in decreased activity of CEL protein16449251
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CEL mRNA23146750
D010634PhenobarbitalPhenobarbital results in increased expression of CEL mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CEL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CEL mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CEL mRNA17426115
D059808PolyphenolsPolyphenols results in decreased activity of CEL protein16099206
D059808PolyphenolsTaurocholic Acid inhibits the reaction [Polyphenols results in decreased activity of CEL protein]16099206
D059808PolyphenolsPolyphenols results in decreased secretion of and affects the activity of CEL protein16099206
D011794QuercetinQuercetin results in increased expression of CEL mRNA21632981
C059514resveratrolresveratrol results in decreased activity of CEL protein16099206
C059514resveratrolresveratrol results in decreased expression of and results in decreased secretion of and results in decreased activity of CEL protein16099206
C059514resveratrolresveratrol results in decreased expression of CEL mRNA16099206
D015474IsotretinoinIsotretinoin results in increased expression of CEL mRNA18769122
C541923sandostatinLARsandostatinLAR results in decreased expression of CEL mRNA17210224
D012643SeleniumSelenium results in increased expression of CEL mRNA19244175
D012834SilverSilver results in increased expression of CEL mRNA27131904
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [Polyphenols results in decreased activity of CEL protein]16099206
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CEL mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CEL mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CEL mRNA15703262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEL mRNA16267337
C009495titanium dioxidetitanium dioxide results in increased expression of CEL mRNA23409001
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CEL mRNA17982090
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CEL mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CEL mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of CEL gene29154799
D015032ZincZinc deficiency results in decreased expression of CEL mRNA15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS2265692  
GO:0004771sterol esterase activity-IBA21873635  
GO:0004771sterol esterase activity-NAS12031288  
GO:0004771sterol esterase activity-TAS-  
GO:0004806triglyceride lipase activity-IBA21873635  
GO:0004806triglyceride lipase activity-NAS2265692  
GO:0005515protein binding-IPI11834744  
GO:0008201heparin binding-NAS7578248  
GO:0016787hydrolase activity-TAS2265692  
GO:0042043neurexin family protein binding-IBA21873635  
GO:0047372acylglycerol lipase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-NAS8639615  
GO:0006707cholesterol catabolic process-IDA12031288  
GO:0006707cholesterol catabolic process-NAS7578248  
GO:0007158neuron cell-cell adhesion-IBA21873635  
GO:0009062fatty acid catabolic process-NAS7578248  
GO:0018350protein esterification-NAS7578248  
GO:0030157pancreatic juice secretion-IDA1854805  
GO:0030299intestinal cholesterol absorption-NAS12031288  
GO:0044241lipid digestion-TAS-  
GO:0044258intestinal lipid catabolic process-NAS7578248  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0097104postsynaptic membrane assembly-IBA21873635  
GO:0097105presynaptic membrane assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005737cytoplasm-ISS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
hsa04972Pancreatic secretion
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29288362Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)Goonesekere NCWJ Cancer Res Clin Oncol
23320113Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study. (2013)Horakova DPLoS One
27117828Advanced glycation endproducts and their receptor in different body compartments in COPD. (2016 Apr 26)Hoonhorst SJRespir Res
24624459Pancreatitis Overview (1993)LaRusch J-
24134530Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification. (2013 Oct 17)van Eupen MGCardiovasc Diabetol