Gene: OLFM4

10562
GC1|GW112|OLM4|OlfD|UNQ362|bA209J19.1|hGC-1|hOLfD
olfactomedin 4
protein-coding
13q14.3
Ensembl:ENSG00000102837 MIM:614061 Vega:OTTHUMG00000016981 UniprotKB:Q6UX06
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.519e-1 (AD)  2.005e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERKL0.621
RFX30.592
MAN1A10.568
NEUROD10.568
AQP90.56
HOPX0.56
KITLG0.548
ZNF1840.545
PCDH80.539
THSD7A0.539

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S1PR5-0.435
GIPR-0.411
PIEZO2-0.378
ANLN-0.377
RHBDL2-0.365
SLC5A11-0.36
MYOT-0.355
PPP1R14A-0.354
MCM7-0.354
NKX6-2-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0342145-iodotubercidin5-iodotubercidin results in decreased expression of OLFM4 mRNA26953159
C016601afimoxifeneafimoxifene results in increased expression of OLFM4 mRNA21048224
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]21048224
D004958EstradiolEstradiol results in increased expression of OLFM4 mRNA21048224
D004958EstradiolICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]]21048224
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of OLFM4 mRNA26945725
D004958EstradiolEstradiol results in increased expression of OLFM4 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of OLFM4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of OLFM4 gene28505145
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in increased expression of OLFM4 mRNA]19228888
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of OLFM4 mRNA20105288
D003907DexamethasoneDexamethasone results in increased expression of OLFM4 mRNA15679045
D003907DexamethasoneDexamethasone results in increased expression of OLFM4 protein15679045
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of OLFM4 mRNA26924002
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of OLFM4 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OLFM4 mRNA17557909
C051781ICI 164384ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]]21048224
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OLFM4 mRNA23103053
C517284monomethyl phthalatemonomethyl phthalate affects the expression of OLFM4 mRNA26924002
D009532NickelNickel results in increased expression of OLFM4 mRNA24768652|2558310
D009538NicotineNicotine results in decreased expression of OLFM4 mRNA23825647
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of OLFM4 mRNA26945725
D012822Silicon DioxideSilicon Dioxide results in increased expression of OLFM4 mRNA23221170
C016104sodium bichromatesodium bichromate results in increased expression of OLFM4 mRNA22561333
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in increased expression of OLFM4 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in increased expression of OLFM4 mRNA19228888
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of OLFM4 mRNA20133372
D014212TretinoinTretinoin results in increased expression of OLFM4 mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of OLFM4 mRNA15901671
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of OLFM4 mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of OLFM4 mRNA20105288
D014635Valproic AcidValproic Acid affects the expression of OLFM4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of OLFM4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of OLFM4 mRNA15901671
C088658zoledronic acidzoledronic acid results in increased expression of OLFM4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IEA-  
GO:0005515protein binding-IPI20534456  25416956  
GO:0042803protein homodimerization activity-IMP16566923  
GO:0045296cadherin binding-IMP16566923  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0010939regulation of necrotic cell deathNOTIMP23922742  
GO:0042981regulation of apoptotic processNOTIMP23922742  
GO:0043312neutrophil degranulation-TAS-  
GO:0050764regulation of phagocytosisNOTIMP23922742  
GO:0051260protein homooligomerization-IMP16566923  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IDA16566923  
GO:2000389regulation of neutrophil extravasationNOTIMP23922742  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA23922742  
GO:0005615extracellular space-IMP16566923  
GO:0005739mitochondrion-IEA-  
GO:0005886plasma membrane-IDA16566923  
GO:0030141secretory granuleNOTIDA23922742  
GO:0035580specific granule lumen-TAS-  
GO:0042581specific granule-IDA23922742  
GO:0042582azurophil granuleNOTIDA23922742  
GO:0048471perinuclear region of cytoplasm-IDA16566923  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25771901Low expression of olfactomedin 4 correlates with poor prognosis in smoking patients with non-small cell lung cancer. (2015 May)Su WHum Pathol