Gene: TXNRD2

10587
GCCD5|SELZ|TR|TR-BETA|TR3|TRXR2
thioredoxin reductase 2
protein-coding
22q11.21
Ensembl:ENSG00000184470 MIM:606448 Vega:OTTHUMG00000149975 UniprotKB:Q9NNW7
NG_011835.1
PubMed
0   ANCO-SNPs
ND
1   
5.449e-2 (AD)  6.817e-1 (ND)   (Frontal_Cortex)
7.319e-2 (AD)  7.519e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPS10.901
PMPCA0.899
ERAL10.898
TRMT2A0.896
ARFRP10.894
RNF2150.886
VPS280.884
UROD0.882
PMM10.878
ARFGAP20.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.62
MTRNR2L6-0.385
MTRNR2L9-0.381
PABPC4L-0.371
C9orf153-0.364
DNASE1L3-0.35
CNTF-0.347
KLRB1-0.34
TBX21-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD2 mRNA"22495766
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TXNRD2 mRNA"23829299
C0671348-oxo-7-hydrodeoxyguanosineTXNRD2 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine19896490
C512352abexinostatabexinostat promotes the reaction [Bortezomib results in decreased expression of TXNRD2 mRNA]19417023
C512352abexinostatabexinostat results in decreased expression of TXNRD2 mRNA19417023
D000082AcetaminophenAcetaminophen results in decreased expression of TXNRD2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TXNRD2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased activity of TXNRD2 protein24661219
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TXNRD2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TXNRD2 gene27153756
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TXNRD2 mRNA]23470461
D001310AuranofinAuranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]19486940
D001310AuranofinAuranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]19486940
D001310AuranofinAuranofin results in decreased activity of TXNRD2 protein21172426|2135585
D001310AuranofinAuranofin results in decreased activity of TXNRD2 protein15458826
D006051AurothioglucoseAurothioglucose results in decreased activity of TXNRD2 protein21172426
C051597Bandrowski's baseBandrowski's base results in increased expression of TXNRD2 mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TXNRD2 mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TXNRD2 mRNA]22228805
D000069286Bortezomibabexinostat promotes the reaction [Bortezomib results in decreased expression of TXNRD2 mRNA]19417023
C013418bromfenacoumbromfenacoum results in increased expression of TXNRD2 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TXNRD2 mRNA14729362|1533650
C034939cadmium sulfidecadmium sulfide results in decreased expression of TXNRD2 mRNA27866839
D002220CarbamazepineCarbamazepine affects the expression of TXNRD2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TXNRD2 mRNA25471833
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TXNRD2 mRNA]25471833
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TXNRD2 mRNA16239168
C026690cerous chloridecerous chloride results in decreased expression of TXNRD2 mRNA28954213
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of TXNRD2 mRNA28219650
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of TXNRD2 mRNA20566472
C018021cobaltous chloridecobaltous chloride results in decreased expression of TXNRD2 mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of TXNRD2 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of TXNRD2 mRNA24921660
C017160cypermethrincypermethrin results in increased expression of TXNRD2 mRNA21142847
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD2 mRNA28659758
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TXNRD2 mRNA27392435
D002945CisplatinCisplatin results in decreased activity of TXNRD2 protein21172426
D002945CisplatinCisplatin results in decreased expression of TXNRD2 mRNA27392435
D004041Dietary Fats[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of TXNRD2 mRNA26042203
D019422Dietary Sucrose[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of TXNRD2 mRNA26042203
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of TXNRD2 mRNA27638505
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of TXNRD2 mRNA20566472
D004221DisulfiramDisulfiram results in increased expression of TXNRD2 mRNA20566472
D004228Dithionitrobenzoic AcidTXNRD2 protein results in increased reduction of Dithionitrobenzoic Acid21172426
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of TXNRD2 mRNA19118595
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of TXNRD2 mRNA14967907
D005054EugenolEugenol results in increased expression of TXNRD2 mRNA20566472
D018120FinasterideFinasteride results in increased expression of TXNRD2 mRNA24136188
D005411Flame RetardantsFlame Retardants results in decreased expression of TXNRD2 protein19858236
D005411Flame RetardantsFlame Retardants results in increased expression of TXNRD2 mRNA19858236
C039281furanfuran results in increased methylation of TXNRD2 gene22079235
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA28433809
D017612Gold CompoundsGold Compounds results in decreased activity of TXNRD2 protein15458826
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased activity of TXNRD2 protein15458826
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA20566472
D017313FenretinideFenretinide results in decreased expression of TXNRD2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TXNRD2 mRNA14729362
D006861Hydrogen PeroxideTXNRD2 protein results in increased metabolism of Hydrogen Peroxide21355852
C036643isoeugenolisoeugenol results in increased expression of TXNRD2 mRNA20566472
D007538IsoniazidIsoniazid affects the expression of TXNRD2 mRNA24848797
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TXNRD2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TXNRD2 mRNA24796395
C005134jugloneTXNRD2 protein results in increased reduction of juglone21172426
C052901lemongrass oillemongrass oil affects the expression of TXNRD2 mRNA25976427
C013091lipoamideTXNRD2 protein results in increased reduction of lipoamide21172426
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TXNRD2 mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of TXNRD2 mRNA]19339665
D008466MechlorethamineMechlorethamine results in decreased activity of TXNRD2 protein24274902
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of TXNRD2 protein24816296
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of TXNRD2 protein17157198
D008628MercuryMercury results in decreased activity of TXNRD2 protein17157198
D008628MercuryMercury results in increased expression of TXNRD2 protein18198945
D008628MercuryTXNRD2 protein affects the susceptibility to Mercury18198945
D008727MethotrexateMethotrexate results in decreased expression of TXNRD2 mRNA24449571
C008435methyldithiocarbamatemethyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased expression of TXNRD2 mRNA]19339665
D008751Methylene Blue[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA24556215
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TXNRD2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TXNRD2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TXNRD2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TXNRD2 mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of TXNRD2 mRNA20566472
C464660obeticholic acidobeticholic acid results in decreased expression of TXNRD2 mRNA27939613
C405603OmacorOmacor results in increased expression of TXNRD2 protein24597798
D050607Organogold CompoundsOrganogold Compounds results in decreased activity of TXNRD2 protein21172426
D010269ParaquatTXNRD2 mutant form results in increased susceptibility to Paraquat23226354
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TXNRD2 protein19858236
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TXNRD2 protein26879310
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD2 mRNA28659758
D010578PetroleumTXNRD2 gene SNP affects the susceptibility to Petroleum21716162
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TXNRD2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TXNRD2 mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of TXNRD2 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of TXNRD2 mRNA25236610
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA28433809
D011192Potassium DichromateAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TXNRD2 mRNA]23470461
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TXNRD2 mRNA23470461
C026899potassium tellurate(IV)potassium tellurate(IV) results in increased activity of TXNRD2 protein19486940
C045950propiconazolepropiconazole affects the expression of TXNRD2 mRNA17383973
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD2 mRNA28659758
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TXNRD2 mRNA]25471833
D012643SeleniumSelenium results in increased activity of TXNRD2 protein15471857
D012643SeleniumSelenium deficiency results in decreased expression of TXNRD2 mRNA15792362|1729144
D012643SeleniumSelenium results in increased expression of TXNRD2 mRNA15792362
D012645SelenomethionineSelenomethionine affects the expression of TXNRD2 mRNA17222674
D012834SilverSilver results in decreased expression of TXNRD2 mRNA19429238|2257657
D018038Sodium SeleniteAuranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]19486940
D018038Sodium SeleniteAuranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]19486940
D018038Sodium SeleniteSodium Selenite results in decreased expression of TXNRD2 mRNA19486940
D018038Sodium SeleniteSodium Selenite results in increased activity of TXNRD2 protein19486940
D043343Testosterone PropionateTestosterone Propionate results in increased expression of TXNRD2 mRNA14967907
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TXNRD2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TXNRD2 mRNA21215274
D013793ThalliumThallium results in decreased expression of TXNRD2 protein28866748
C016797triethyl phosphine goldtriethyl phosphine gold results in decreased activity of TXNRD2 protein15458826
D014303TrinitrotolueneTrinitrotoluene affects the expression of TXNRD2 mRNA21346803
D014415TunicamycinTunicamycin results in decreased expression of TXNRD2 mRNA17127020
D014520UrethaneUrethane results in decreased expression of TXNRD2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TXNRD2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TXNRD2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TXNRD2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of TXNRD2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TXNRD2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004791thioredoxin-disulfide reductase activity-EXP17707404  
GO:0004791thioredoxin-disulfide reductase activity-IBA21873635  
GO:0004791thioredoxin-disulfide reductase activity-ISS-  
GO:0005515protein binding-IPI20413580  
GO:0009055electron transfer activity-IEA-  
GO:0016667oxidoreductase activity, acting on a sulfur group of donors-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000305response to oxygen radical-TAS10455115  
GO:0022900electron transport chain-IEA-  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0045454cell redox homeostasis-IBA21873635  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA10215850  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00450Selenocompound metabolism
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27186328Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. (2016)Slattery MLInt J Mol Epidemiol Genet