Gene: MTHFS

10588
HsT19268
methenyltetrahydrofolate synthetase
protein-coding
15q25.1
Ensembl:ENSG00000136371 MIM:604197 Vega:OTTHUMG00000144174 UniprotKB:P49914
NG_029243.1
PubMed
0   ANCO-SNPs
ND
2   
7.371e-1 (AD)  2.512e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C60.85
HSCB0.837
SNRPG0.833
RPS27L0.83
COA40.802
SEC61B0.792
ZFAND60.783
DBI0.779
GTF2A20.777
CSTB0.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.547
OR4F29-0.52
PCDHAC1-0.314
ATP12A-0.289
DCC-0.287
MAS1-0.279
IL1RAPL2-0.277
PCDHA12-0.271
PLEKHD1-0.267
ADRA1D-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTHFS mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MTHFS mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of MTHFS mRNA21983209
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MTHFS mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of MTHFS mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of MTHFS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTHFS mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTHFS gene27153756
D000638AmiodaroneAmiodarone affects the expression of MTHFS mRNA25064622
C487081belinostatbelinostat results in decreased expression of MTHFS mRNA27188386
C044887beta-methylcholinebeta-methylcholine affects the expression of MTHFS mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MTHFS mRNA25181051
C584509C646 compoundC646 compound results in increased expression of MTHFS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MTHFS mRNA21457566
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MTHFS protein24527689
D002746ChlorpromazineChlorpromazine affects the expression of MTHFS mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTHFS mRNA17553155
D019327Copper SulfateCopper Sulfate results in decreased expression of MTHFS mRNA19549813
D016572CyclosporineCyclosporine affects the expression of MTHFS mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of MTHFS mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MTHFS mRNA17361019|2126653
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTHFS mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTHFS mRNA17942748
D018120FinasterideFinasteride results in increased expression of MTHFS mRNA24136188
C039281furanfuran results in increased methylation of MTHFS gene22079235
D005897GlafenineGlafenine results in decreased expression of MTHFS mRNA24136188
C492448ICG 001ICG 001 results in increased expression of MTHFS mRNA26191083
C051890irinotecanirinotecan metabolite results in decreased expression of MTHFS mRNA15956246
C051890irinotecanirinotecan results in decreased expression of MTHFS mRNA15956246
C045463leflunomideleflunomide results in increased expression of MTHFS mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTHFS mRNA23649840
C006374N-acetyldopamineN-acetyldopamine binds to MTHFS protein17055997
C006374N-acetyldopamineN-acetyldopamine binds to MTHFS protein17055997
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MTHFS mRNA"25620056
C051752nefazodonenefazodone results in increased expression of MTHFS mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MTHFS mRNA25729387
D010269ParaquatParaquat affects the expression of MTHFS mRNA25064622
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MTHFS mRNA23602845
C006253pirinixic acidpirinixic acid results in increased expression of MTHFS mRNA18301758
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MTHFS mRNA23608068
D012999SomanSoman results in increased expression of MTHFS mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTHFS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTHFS mRNA17942748
D013752TetracyclineTetracycline affects the expression of MTHFS mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of MTHFS mRNA25064622
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MTHFS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MTHFS mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MTHFS gene27618143
D014635Valproic AcidValproic Acid affects the expression of MTHFS mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of MTHFS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MTHFS gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IDA19738041  
GO:0005542folic acid binding-IDA7766710  19738041  
GO:00302725-formyltetrahydrofolate cyclo-ligase activity-IBA21873635  
GO:00302725-formyltetrahydrofolate cyclo-ligase activity-IDA7766710  19738041  
GO:00302725-formyltetrahydrofolate cyclo-ligase activity-IMP12764149  
GO:00302725-formyltetrahydrofolate cyclo-ligase activity-NAS8522195  
GO:00302725-formyltetrahydrofolate cyclo-ligase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006536glutamate metabolic process-IMP12764149  
GO:0009396folic acid-containing compound biosynthetic process-IBA21873635  
GO:0015942formate metabolic process-NAS8522195  
GO:0035999tetrahydrofolate interconversion-IBA21873635  
GO:0035999tetrahydrofolate interconversion-IMP12764149  
GO:0046653tetrahydrofolate metabolic process-IDA7766710  19738041  
GO:0046655folic acid metabolic process-TAS-  
GO:0046657folic acid catabolic process-IMP12764149  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA7766710  
GO:0005739mitochondrion-IBA21873635  
GO:0005759mitochondrial matrix-IDA7766710  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
23552396Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. (2013 Jun)Tajuddin SMEnviron Health Perspect