Gene: SMC2

10592
CAP-E|CAPE|SMC-2|SMC2L1
structural maintenance of chromosomes 2
protein-coding
9q31.1
Ensembl:ENSG00000136824 MIM:605576 Vega:OTTHUMG00000020401 UniprotKB:O95347
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
1.258e-1 (AD)  7.549e-1 (ND)   (Frontal_Cortex)
6.544e-1 (AD)  6.928e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LANCL10.883
CCSER20.876
CEP1700.874
ZNF33A0.866
STX70.866
AGGF10.86
CLASP20.86
LYRM70.858
PRUNE20.858
TTC370.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.42
CSAG1-0.409
OR4F29-0.39
PDZK1IP1-0.385
EVC2-0.362
MTRNR2L10-0.355
SOD3-0.351
SERPINH1-0.349
MTRNR2L6-0.348
S100A14-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SMC2 mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SMC2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SMC2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SMC2 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of SMC2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of SMC2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SMC2 protein20106945
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of SMC2 mRNA"22863853
D001379AzathioprineAzathioprine results in decreased expression of SMC2 mRNA22623647
D001554BenzeneBenzene results in decreased expression of SMC2 mRNA20018183
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SMC2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMC2 mRNA21802500
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMC2 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of SMC2 mRNA16474171|1916744
C006780bisphenol Abisphenol A affects the expression of SMC2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SMC2 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of SMC2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SMC2 mRNA25181051|2698221
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMC2 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SMC2 mRNA27793765
C018021cobaltous chloridecobaltous chloride results in decreased expression of SMC2 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of SMC2 mRNA15467011
D003300CopperCopper results in increased expression of SMC2 mRNA17205981
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SMC2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SMC2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SMC2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SMC2 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of SMC2 mRNA20579391
D002945CisplatinCisplatin results in decreased expression of SMC2 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of SMC2 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of SMC2 mRNA19680557
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SMC2 mRNA27614199
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SMC2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMC2 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SMC2 mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of SMC2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SMC2 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SMC2 mRNA25380136
D004221DisulfiramDisulfiram results in decreased expression of SMC2 mRNA20530235
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMC2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMC2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMC2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNA17942748
C026098etiracetametiracetam results in increased expression of SMC2 mRNA20345932
D019833GenisteinGenistein results in increased expression of SMC2 mRNA16474171
D005839GentamicinsGentamicins results in increased expression of SMC2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of SMC2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SMC2 mRNA25613284
D007840LatexLatex analog results in increased expression of SMC2 mRNA24768652
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SMC2 mRNA21641980
D008701MethapyrileneMethapyrilene results in increased expression of SMC2 mRNA22584684
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SMC2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SMC2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SMC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMC2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SMC2 mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SMC2 mRNA19812364
D009532NickelNickel results in increased expression of SMC2 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SMC2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SMC2 mRNA25729387
D010126OzoneOzone results in increased expression of SMC2 mRNA12763052
C016030pantogabpantogab results in decreased expression of SMC2 mRNA17379144
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SMC2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of SMC2 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SMC2 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SMC2 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of SMC2 mRNA19136022|2309116
D010672PhenytoinPhenytoin results in increased expression of SMC2 mRNA20345932
C006253pirinixic acidpirinixic acid affects the expression of SMC2 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of SMC2 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of SMC2 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of SMC2 mRNA]17950772
D010894PiroxicamPiroxicam results in decreased expression of SMC2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of SMC2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of SMC2 mRNA16474171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMC2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMC2 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of SMC2 mRNA18070364
C005556propionaldehydepropionaldehyde results in decreased expression of SMC2 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of SMC2 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SMC2 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of SMC2 mRNA25905778
D053260SootSoot results in increased expression of SMC2 mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SMC2 mRNA21641980
C013698tallowtallow affects the expression of SMC2 mRNA19680557
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SMC2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SMC2 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of SMC2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMC2 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMC2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SMC2 mRNA25613284
D013893ThiramThiram results in decreased expression of SMC2 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SMC2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SMC2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SMC2 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SMC2 mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of SMC2 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of SMC2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SMC2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of SMC2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SMC2 mRNA29154799
D014638VanadatesVanadates results in decreased expression of SMC2 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in increased expression of SMC2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12589063  17113138  17268547  17314511  17353931  21633354  
23728299  26496610  
GO:0005524ATP binding-IEA-  
GO:0046982protein heterodimerization activity-IPI9789013  
GO ID GO Term Qualifier Evidence PubMed
GO:0007076mitotic chromosome condensation-IDA11136719  
GO:0010032meiotic chromosome condensation-IEA-  
GO:0045132meiotic chromosome segregation-IEA-  
GO:0051301cell division-IEA-  
GO:0051383kinetochore organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IDA10958694  
GO:0000793condensed chromosome-IDA12589063  
GO:0000796condensin complex-IDA10958694  11136719  
GO:0005634nucleus-IDA12589063  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA10958694  12589063  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-2514853Condensation of Prometaphase ChromosomesTAS
R-HSA-2514853Condensation of Prometaphase ChromosomesIEA
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68877Mitotic PrometaphaseIEA
R-HSA-68886M PhaseTAS
R-HSA-68886M PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21618603Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. (2011 Sep)Beaty THGenet Epidemiol