Gene: SLCO1B1

10599
HBLRR|LST-1|LST1|OATP-C|OATP1B1|OATP2|OATPC|SLC21A6
solute carrier organic anion transporter family member 1B1
protein-coding
12p12.1
Ensembl:ENSG00000134538 MIM:604843 Vega:OTTHUMG00000169047 UniprotKB:Q9Y6L6
NG_011745.1
PubMed
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.903e-1 (AD)  5.219e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF170.825
OR56A40.824
PRDM140.823
OR10K10.819
OR9Q20.817
TAS2R410.814
TMEM2470.811
OR2A140.803
TAS2R300.795
POU5F20.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB41-0.28
CENPH-0.244
CLDND2-0.243
ESPN-0.234
CHEK1-0.232
HEY1-0.231
RSPH10B-0.227
FBXL22-0.225
ARMC4-0.225
GDF9-0.223

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTransporter
DB00175PravastatinSmall Molecule81093-37-0ApprovedTransporter
DB00177ValsartanSmall Molecule137862-53-4Approved|InvestigationalTransporter
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnTransporter
DB00199ErythromycinSmall Molecule114-07-8Approved|InvestigationalTransporter
DB00213PantoprazoleSmall Molecule102625-70-7ApprovedTransporter
DB00220NelfinavirSmall Molecule159989-64-7ApprovedTransporter
DB00224IndinavirSmall Molecule150378-17-9ApprovedTransporter
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalTransporter
DB00275OlmesartanSmall Molecule144689-24-7Approved|InvestigationalTransporter
DB00279LiothyronineSmall Molecule6893-02-3ApprovedTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00390DigoxinSmall Molecule20830-75-5ApprovedTransporter
DB00412RosiglitazoneSmall Molecule122320-73-4Approved|InvestigationalTransporter
DB00439CerivastatinSmall Molecule145599-86-6Approved|WithdrawnTransporter
DB00451LevothyroxineSmall Molecule51-48-9ApprovedTransporter
DB00503RitonavirSmall Molecule155213-67-5Approved|InvestigationalTransporter
DB00509DextrothyroxineSmall Molecule51-49-0Approved|InvestigationalTransporter
DB00520CaspofunginSmall Molecule162808-62-0ApprovedTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00583L-CarnitineSmall Molecule541-15-1Approved|InvestigationalTransporter
DB00641SimvastatinSmall Molecule79902-63-9ApprovedTransporter
DB00655EstroneSmall Molecule53-16-7ApprovedTransporter
DB00661VerapamilSmall Molecule52-53-9ApprovedTransporter
DB00669SumatriptanSmall Molecule103628-46-2Approved|InvestigationalTransporter
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalTransporter
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00859PenicillamineSmall Molecule52-67-5ApprovedTransporter
DB00877SirolimusSmall Molecule53123-88-9Approved|InvestigationalTransporter
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTransporter
DB00912RepaglinideSmall Molecule135062-02-1Approved|InvestigationalTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00950FexofenadineSmall Molecule83799-24-0Approved|InvestigationalTransporter
DB00973EzetimibeSmall Molecule163222-33-1ApprovedTransporter
DB01045RifampicinSmall Molecule13292-46-1ApprovedTransporter
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTransporter
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedTransporter
DB01092OuabainSmall Molecule630-60-4ApprovedTransporter
DB01095FluvastatinSmall Molecule93957-54-1ApprovedTransporter
DB01098RosuvastatinSmall Molecule287714-41-4ApprovedTransporter
DB01132PioglitazoneSmall Molecule111025-46-8Approved|InvestigationalTransporter
DB01232SaquinavirSmall Molecule127779-20-8Approved|InvestigationalTransporter
DB01241GemfibrozilSmall Molecule25812-30-0ApprovedTransporter
DB01393BezafibrateSmall Molecule41859-67-0Approved|InvestigationalTransporter
DB01583LiotrixSmall Molecule8065-29-0ApprovedTransporter
DB01892HyperforinSmall Molecule11079-53-1NutraceuticalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB02691Glycocholic acidSmall Molecule475-31-0Experimental|InvestigationalTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB04850PosizolidSmall Molecule252260-06-3InvestigationalTransporter
DB04881ElacridarSmall Molecule143664-11-3InvestigationalTransporter
DB05239CobimetinibSmall Molecule934660-93-2Approved|InvestigationalTransporter
DB05804Prasterone sulfateSmall Molecule651-48-9InvestigationalTransporter
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTransporter
DB06191ZosuquidarSmall Molecule167354-41-8InvestigationalTransporter
DB06210EltrombopagSmall Molecule496775-61-2ApprovedTransporter
DB06290SimeprevirSmall Molecule923604-59-5ApprovedTransporter
DB06403AmbrisentanSmall Molecule177036-94-1Approved|InvestigationalTransporter
DB06589PazopanibSmall Molecule444731-52-6ApprovedTransporter
DB06626AxitinibSmall Molecule319460-85-0Approved|InvestigationalTransporter
DB06721GimatecanSmall Molecule292618-32-7InvestigationalTransporter
DB06772CabazitaxelSmall Molecule183133-96-2ApprovedTransporter
DB08855Leukotriene C4Small Molecule72025-60-6Experimental|InvestigationalTransporter
DB08856DADLESmall Molecule63631-40-3ExperimentalTransporter
DB08860PitavastatinSmall Molecule147511-69-1ApprovedTransporter
DB08864RilpivirineSmall Molecule500287-72-9ApprovedTransporter
DB08884Gadoxetic acidSmall Molecule135326-11-3ApprovedTransporter
DB08912DabrafenibSmall Molecule-Approved|InvestigationalTransporter
DB09054IdelalisibSmall Molecule870281-82-6ApprovedTransporter
DB09102DaclatasvirSmall Molecule1009119-64-5Approved|InvestigationalTransporter
DB09137Technetium Tc-99m mebrofeninSmall Molecule1415247-71-0ApprovedTransporter
DB09198LobeglitazoneSmall Molecule607723-33-1Approved|InvestigationalTransporter
DB09272EluxadolineSmall Molecule864821-90-9Approved|InvestigationalTransporter
DB09292SacubitrilSmall Molecule149709-62-6ApprovedTransporter
DB11362SelexipagSmall Molecule475086-01-2ApprovedTransporter
DB11575GrazoprevirSmall Molecule1350514-68-9ApprovedTransporter
DB11613VelpatasvirSmall Molecule1377049-84-7Approved|InvestigationalTransporter
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTransporter
DB12026VoxilaprevirSmall Molecule1535212-07-7Approved|InvestigationalTransporter
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalTransporter
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTransporter
DB13139LevosalbutamolSmall Molecule34391-04-3Approved|InvestigationalTransporter
DB13153LevomenolSmall Molecule23089-26-1Approved|ExperimentalTransporter
DB13154ParachlorophenolSmall Molecule106-48-9ApprovedTransporter
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalTransporter
DB13878PibrentasvirSmall Molecule1353900-92-1Approved|InvestigationalTransporter
DB13879GlecaprevirSmall Molecule1365970-03-1Approved|InvestigationalTransporter
DB13928SemaglutideSmall Molecule910463-68-2Approved|InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
DB01045RifampicinSmall Molecule13292-46-1ApprovedTarget
DB01211ClarithromycinSmall Molecule81103-11-9ApprovedTarget
DB05521TelaprevirSmall Molecule402957-28-2Approved|WithdrawnTarget
ID Drug Name Action PubMed
C0549172,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid"2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Cyclic AMP analog]"25542188
C0549172,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid"2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid results in decreased activity of SLCO1B1 protein"25542188
C5558592,2',4,4',5,6'-hexabromodiphenyl ether"2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]"20176623
C5558592,2',4,4',5,6'-hexabromodiphenyl ether"SLCO1B1 results in increased import of 2,2',4,4',5,6'-hexabromodiphenyl ether"20176623
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]"20176623
C5112952,2',4,4'-tetrabromodiphenyl ether"SLCO1B1 results in increased import of 2,2',4,4'-tetrabromodiphenyl ether"20176623
C5211042-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]19223659
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
C0067574-biphenylamine4-biphenylamine inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C561635(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acidSLCO1B1 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid21661758
C561635(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acidSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]21661758
C0005889585-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of SLCO1B1 protein23631744
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLCO1B1 mRNA29067470
D000242Cyclic AMP"2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Cyclic AMP analog]"25542188
D000242Cyclic AMPSLCO1B1 protein results in increased uptake of Cyclic AMP analog25542188
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLCO1B1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLCO1B1 mRNA22100608
D000447AldehydesAldehydes results in decreased expression of SLCO1B1 mRNA25014914
D019804MesalamineBudesonide inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D019804MesalamineCyclosporine inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D019804MesalaminePravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D019804MesalamineRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D019804MesalamineSLCO1B1 protein results in increased uptake of Mesalamine21430235
D047310ApigeninApigenin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
D047310ApigeninApigenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D001151ArsenicSLCO1B1 gene SNP affects the abundance of Arsenic metabolite23970802
C025657arsenic acidSLCO1B1 protein results in increased import of arsenic acid16479312
C015001arseniteSLCO1B1 protein results in increased import of arsenite16479312
C015001arseniteSLCO1B1 protein results in increased import of arsenite analog16479312
D000069059Atorvastatin CalciumApigenin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased activity of SLCO1B1 protein15616150
D000069059Atorvastatin Calciumglimepiride inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin CalciumGlyburide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin Calciumkaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
D000069059Atorvastatin Calciumnateglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin Calciumpioglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin CalciumQuercetin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
D000069059Atorvastatin Calciumrepaglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin Calciumrosiglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000069059Atorvastatin CalciumSLCO1B1 gene SNP results in decreased transport of Atorvastatin Calcium15970799
D000069059Atorvastatin CalciumSLCO1B1 protein results in increased import of Atorvastatin Calcium22394605
D000069059Atorvastatin CalciumSLCO1B1 protein results in increased uptake of Atorvastatin Calcium23121773|2510641
D000069059Atorvastatin CalciumSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]25106415
C487081belinostatbelinostat results in increased expression of SLCO1B1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
D001629BezafibrateBezafibrate inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLCO1B1 protein results in increased uptake of Phalloidine]19464309
D001647Bile Acids and SaltsBile Acids and Salts inhibits the reaction [SLCO1B1 protein results in increased uptake of Taurocholic Acid]19464309
D001647Bile Acids and SaltsSLCO1B1 protein affects the transport of Bile Acids and Salts15841457
D001647Bile Acids and SaltsSLCO1B1 protein affects the uptake of Bile Acids and Salts15841457
D001647Bile Acids and SaltsTAK-875 inhibits the reaction [SLCO1B1 protein results in increased transport of Bile Acids and Salts]28108665
D001647Bile Acids and SaltsBile Acids and Salts analog inhibits the reaction [SLCO1B1 protein results in increased uptake of Phalloidine]19409403
D001663BilirubinBilirubin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D001663BilirubinBilirubin results in increased expression of SLCO1B1 mRNA15382119
D001663BilirubinIL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA]15382119
C054146bilirubin ditaurinebilirubin ditaurine inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D001664BiliverdineBiliverdine inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C006780bisphenol Abisphenol A inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C006780bisphenol Abisphenol A results in decreased activity of SLCO1B1 protein27989701
C000611646bisphenol Fbisphenol F inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C000611646bisphenol Fbisphenol F results in decreased activity of SLCO1B1 protein27989701
D019819BudesonideBudesonide inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D019819BudesonideBudesonide inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
C018475butyraldehydebutyraldehyde results in decreased expression of SLCO1B1 mRNA26079696
D002101Cacodylic AcidSLCO1B1 gene SNP results in increased abundance of Cacodylic Acid23970802
D002220CarbamazepineCarbamazepine results in increased expression of SLCO1B1 mRNA17112801
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SLCO1B1 mRNA24763279
C086276cerivastatinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to cerivastatin]23564645
C086276cerivastatinSLCO1B1 gene SNP results in decreased transport of cerivastatin15970799
C086276cerivastatinSLCO1B1 protein results in increased uptake of and results in increased susceptibility to cerivastatin23564645
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SLCO1B1 mRNA27174168
D019826Cholic AcidSLCO1B1 protein results in increased uptake of Cholic Acid16534140
D019826Cholic AcidSLCO1B1 SNP results in increased abundance of Cholic Acid22022402
D017291ClarithromycinClarithromycin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D017291ClarithromycinClarithromycin results in decreased activity of SLCO1B1 protein23748747
D003010ClorgylineClorgyline results in increased expression of SLCO1B1 mRNA19691856
D003306CoproporphyrinsCoproporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C057862cyanoginosin LRDehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]26134461
C057862cyanoginosin LRRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to cyanoginosin LR]23564645
C057862cyanoginosin LRSLCO1B1 protein results in increased susceptibility to cyanoginosin LR17369605|2017123
C057862cyanoginosin LRSLCO1B1 protein results in increased uptake of and results in increased susceptibility to cyanoginosin LR23564645
C057862cyanoginosin LRSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]20171238|2613446
C057862cyanoginosin LRTaurocholic Acid inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]26134461
D016572CyclosporineCyclosporine inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D016572CyclosporineCyclosporine inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D016572CyclosporineCyclosporine results in decreased activity of SLCO1B1 protein16316932
D016572CyclosporineCyclosporine results in decreased expression of SLCO1B1 mRNA20106945|2798913
D019314Dehydroepiandrosterone SulfateDehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]26134461
D019314Dehydroepiandrosterone SulfateDehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D003840Deoxycholic AcidSLCO1B1 protein results in increased uptake of Deoxycholic Acid16534140
D003905DeuteroporphyrinsDeuteroporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO1B1 mRNA27392435
C095803E 3040[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of E 3040 analog19628752
D004656EnalaprilSLCO1B1 gene polymorphism affects the abundance of Enalapril21665049
D015773EnalaprilatSLCO1B1 gene polymorphism affects the abundance of Enalaprilat21665049
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLCO1B1 mRNA26159488
C025483estradiol-17 beta-glucuronide"2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]"20176623
C025483estradiol-17 beta-glucuronide"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]"20176623
C025483estradiol-17 beta-glucuronide2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]19223659
C025483estradiol-17 beta-glucuronideAtorvastatin Calcium inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
C025483estradiol-17 beta-glucuronideBezafibrate inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
C025483estradiol-17 beta-glucuronidebilirubin ditaurine inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideBilirubin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideBiliverdine inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideCoproporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideDeuteroporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronidefenofibric acid inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
C025483estradiol-17 beta-glucuronideGemfibrozil inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
C025483estradiol-17 beta-glucuronideHematoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideLovastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
C025483estradiol-17 beta-glucuronideMesoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronidepentabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]20176623
C025483estradiol-17 beta-glucuronidephytochlorin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronidePKI 166 inhibits the reaction [SLCO1B1 protein affects the transport of estradiol-17 beta-glucuronide]15280219
C025483estradiol-17 beta-glucuronideProtoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C025483estradiol-17 beta-glucuronideRifampin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]16479312
C025483estradiol-17 beta-glucuroniderifamycin SV inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
C025483estradiol-17 beta-glucuronideSimvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
C025483estradiol-17 beta-glucuronideSLCO1B1 protein affects the uptake of estradiol-17 beta-glucuronide15652233
C025483estradiol-17 beta-glucuronide[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide19628752
C025483estradiol-17 beta-glucuronide[SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide18180276
C025483estradiol-17 beta-glucuronideSLCO1B1 protein mutant form results in decreased transport of estradiol-17 beta-glucuronide19238167
C025483estradiol-17 beta-glucuronideSLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide16479312|1956044
C025483estradiol-17 beta-glucuronideSLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide15616150|1923816
C025483estradiol-17 beta-glucuronideSLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide16316932|1922365
C025483estradiol-17 beta-glucuronideSLCO1B1 results in increased import of estradiol-17 beta-glucuronide20176623
C017296estrone sulfate4-biphenylamine inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C017296estrone sulfate4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C017296estrone sulfatebisphenol A inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfatebisphenol F inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfateSLCO1B1 protein affects the uptake of estrone sulfate15652233
C017296estrone sulfateSLCO1B1 protein mutant form results in decreased transport of estrone sulfate19238167
C017296estrone sulfateSLCO1B1 protein results in increased import of estrone sulfate27450509
C017296estrone sulfateSLCO1B1 protein results in increased transport of estrone sulfate19238167|2145755
C017296estrone sulfateSLCO1B1 protein results in increased uptake of estrone sulfate25106415|2798970
C017296estrone sulfateSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C017296estrone sulfateSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]25106415|2798970
C017296estrone sulfatetetrabromobisphenol A inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfateTobacco Smoke Pollution inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
C006012fenofibric acidfenofibric acid inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
C093230fexofenadine[SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine18180276
C093230fexofenadineSLCO1B1 protein results in increased uptake of fexofenadine18245269
C065180fluvastatinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to fluvastatin]23564645
C065180fluvastatinSLCO1B1 protein affects the import of fluvastatin16046661
C065180fluvastatinSLCO1B1 protein results in increased uptake of and results in increased susceptibility to fluvastatin23564645
D005672Fusidic AcidFusidic Acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Rosuvastatin Calcium]26888941
D005672Fusidic AcidFusidic Acid results in decreased activity of SLCO1B1 protein27676153
D015248GemfibrozilGemfibrozil inhibits the reaction [SLCO1B1 protein results in increased uptake of estradiol-17 beta-glucuronide]16316932
C094370gemfibrozil 1-O-acylglucuronide[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of gemfibrozil 1-O-acylglucuronide19628752
C057619glimepirideglimepiride affects the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]23121773
C057619glimepirideglimepiride inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D005978GlutathioneSLCO1B1 protein results in increased import of Glutathione analog16479312
D005905GlyburideGlyburide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D006000Glycocholic AcidSLCO1B1 SNP results in increased abundance of Glycocholic Acid22022402
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SLCO1B1 mRNA24763279
D006415HematoporphyrinsHematoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D006415HematoporphyrinsHematoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]19560444
D006888HydroxycholesterolsSLCO1B1 SNP results in increased abundance of Hydroxycholesterols analog22022402
D006918HydroxyureaSLCO1B1 protein results in increased uptake of Hydroxyurea21256917
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO1B1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SLCO1B1 mRNA27392435
C006552kaempferolkaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
C006552kaempferolkaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D007654KetoconazoleKetoconazole results in decreased expression of SLCO1B1 mRNA16608920
D008095Lithocholic AcidSLCO1B1 protein results in increased uptake of Lithocholic Acid16534140
D008095Lithocholic AcidSLCO1B1 SNP results in increased abundance of Lithocholic Acid22022402
D008095Lithocholic Acid[SLCO1B1 SNP results in increased abundance of Lithocholic Acid] which results in increased susceptibility to Simvastatin22022402
D008148LovastatinLovastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
D008148LovastatinLovastatin results in decreased activity of SLCO1B1 protein15616150
D008652MesoporphyrinsMesoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D008727MethotrexateSLCO1B1 gene SNP affects the abundance of Methotrexate24712521
D008727MethotrexateSLCO1B1 gene SNP affects the susceptibility to Methotrexate21387541
D008727MethotrexateSLCO1B1 gene SNP results in increased susceptibility to Methotrexate25124723
C078588microcystinSLCO1B1 protein results in increased susceptibility to microcystin analog20171238
C524165microcystin-LFSLCO1B1 protein results in increased susceptibility to microcystin-LF20171238
D052998MicrocystinsSLCO1B1 protein results in increased uptake of Microcystins20472527
C020300monomethylarsonic acidSLCO1B1 gene SNP results in decreased abundance of monomethylarsonic acid23970802
C005273naringeninnaringenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
C005274naringinnaringin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
C060142nateglinidenateglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
C464660obeticholic acidobeticholic acid results in decreased expression of SLCO1B1 mRNA27939613
C025589ochratoxin ASLCO1B1 protein affects the uptake of ochratoxin A28532671
D019319Okadaic AcidDehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D019319Okadaic AcidSLCO1B1 protein results in increased susceptibility to Okadaic Acid26134461
D019319Okadaic AcidSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D019319Okadaic AcidTaurocholic Acid inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D052638Particulate MatterParticulate Matter results in decreased activity of SLCO1B1 protein25803276
C086401pentabromodiphenyl etherpentabromodiphenyl ether inhibits the reaction [SLCO1B1 results in increased import of estradiol-17 beta-glucuronide]20176623
C086401pentabromodiphenyl etherSLCO1B1 results in increased import of pentabromodiphenyl ether20176623
C046012pentanalpentanal results in decreased expression of SLCO1B1 mRNA26079696
C539348perfluorobutanesulfonic acidSLCO1B1 protein results in increased transport of perfluorobutanesulfonic acid28013215
C471071perfluorohexanesulfonic acidSLCO1B1 protein results in increased transport of perfluorohexanesulfonic acid28013215
C076994perfluorooctane sulfonic acidSLCO1B1 protein results in increased transport of perfluorooctane sulfonic acid28013215
D010590PhalloidineBile Acids and Salts inhibits the reaction [SLCO1B1 protein results in increased uptake of Phalloidine]19464309
D010590PhalloidineSLCO1B1 protein results in increased uptake of Phalloidine19464309|2528077
D010590PhalloidineBile Acids and Salts analog inhibits the reaction [SLCO1B1 protein results in increased uptake of Phalloidine]19409403
D010590PhalloidineSLCO1B1 protein results in increased uptake of Phalloidine19409403
C033457phenobarbital quinidineIL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of SLCO1B1 mRNA]15382119
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of SLCO1B1 mRNA15382119
C062985phytochlorinphytochlorin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
C062985phytochlorinphytochlorin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]19560444
C060836pioglitazonepioglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
C108475pitavastatinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to pitavastatin]23564645
C108475pitavastatinSLCO1B1 protein affects the transport of pitavastatin15955871
C108475pitavastatinSLCO1B1 protein results in increased uptake of and results in increased susceptibility to pitavastatin23564645
C410026PKI 166PKI 166 inhibits the reaction [SLCO1B1 protein affects the transport of estradiol-17 beta-glucuronide]15280219
C410026PKI 166PKI 166 results in decreased activity of SLCO1B1 protein15280219
C410026PKI 166SLCO1B1 protein affects the transport of PKI 166 metabolite15280219
D017035PravastatinPravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D017035PravastatinPravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D017035PravastatinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Pravastatin]23564645
D017035PravastatinSLCO1B1 gene SNP results in decreased transport of Pravastatin15970799
D017035PravastatinSLCO1B1 gene SNP results in increased susceptibility to Pravastatin15681900
D017035PravastatinSLCO1B1 protein mutant form results in decreased transport of Pravastatin19238167
D017035PravastatinSLCO1B1 protein results in increased transport of Pravastatin19238167
D017035PravastatinSLCO1B1 protein results in increased uptake of and results in increased susceptibility to Pravastatin23564645
D017035PravastatinPravastatin affects the localization of SLCO1B1 protein22216116
D017035PravastatinSLCO1B1 results in increased uptake of Pravastatin22216116
C005556propionaldehydepropionaldehyde results in decreased expression of SLCO1B1 mRNA26079696
D011524ProtoporphyrinsProtoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]19560444
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of SLCO1B1 mRNA26100227
D011794QuercetinQuercetin inhibits the reaction [SLCO1B1 protein results in increased import of Atorvastatin Calcium]22394605
D011794QuercetinQuercetin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D011794QuercetinSLCO1B1 protein results in increased uptake of Quercetin24947867
C072379repagliniderepaglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
C072379repaglinideSLCO1B1 gene SNP affects the metabolism of repaglinide15961978
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide]16479312
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased import of Taurocholic Acid]16479312
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to cerivastatin]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to cyanoginosin LR]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to fluvastatin]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to pitavastatin]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Pravastatin]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Rosuvastatin Calcium]23564645
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine]21430235
D012293RifampinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D012293RifampinRifampin results in decreased activity of SLCO1B1 protein23564645
D012293RifampinRifampin results in increased expression of SLCO1B1 mRNA15670600|1683756
D012293RifampinSLCO1B1 protein affects the uptake of Rifampin15652233
C023808rifamycin SVrifamycin SV inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
C023808rifamycin SVrifamycin SV results in decreased activity of SLCO1B1 protein15616150
C089730rosiglitazonerosiglitazone inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]23121773
D000068718Rosuvastatin CalciumFusidic Acid inhibits the reaction [SLCO1B1 protein results in increased uptake of Rosuvastatin Calcium]26888941
D000068718Rosuvastatin CalciumRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of and results in increased susceptibility to Rosuvastatin Calcium]23564645
D000068718Rosuvastatin CalciumSLCO1B1 protein results in increased uptake of and results in increased susceptibility to Rosuvastatin Calcium23564645
D000068718Rosuvastatin CalciumSLCO1B1 protein results in increased uptake of Rosuvastatin Calcium26888941
D012431RutinRutin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLCO1B1 mRNA25895662
D019821SimvastatinSimvastatin inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]15616150
D019821SimvastatinSimvastatin results in decreased activity of SLCO1B1 protein15616150
D019821SimvastatinSLCO1B1 gene SNP results in increased susceptibility to Simvastatin18650507|1983326
D019821SimvastatinSLCO1B1 mutant form affects the susceptibility to Simvastatin21243006
D019821SimvastatinSLCO1B1 polymorphism affects the susceptibility to Simvastatin analog17108811
D019821Simvastatin[SLCO1B1 SNP results in increased abundance of Lithocholic Acid] which results in increased susceptibility to Simvastatin22022402
D019821Simvastatin[SLCO1B1 SNP results in increased abundance of Taurolithocholic Acid] which results in increased susceptibility to Simvastatin22022402
D019821SimvastatinSimvastatin affects the localization of SLCO1B1 protein22216116
C532833simvastatin hydroxyacidSLCO1B1 gene polymorphism results in increased abundance of simvastatin hydroxyacid24403518
D013265StigmasterolSLCO1B1 SNP results in increased abundance of Stigmasterol22022402
D013448SulfobromophthaleinApigenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448SulfobromophthaleinBudesonide inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D013448SulfobromophthaleinClarithromycin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D013448SulfobromophthaleinCyclosporine inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D013448Sulfobromophthaleinglimepiride affects the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]23121773
D013448SulfobromophthaleinHematoporphyrins inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]19560444
D013448Sulfobromophthaleinkaempferol inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448Sulfobromophthaleinnaringenin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448Sulfobromophthaleinnaringin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448Sulfobromophthaleinphytochlorin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]19560444
D013448SulfobromophthaleinPravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D013448SulfobromophthaleinQuercetin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448SulfobromophthaleinRifampin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein]21430235
D013448SulfobromophthaleinRutin inhibits the reaction [SLCO1B1 protein results in increased import of Sulfobromophthalein]22394605
D013448SulfobromophthaleinSLCO1B1 protein affects the import of Sulfobromophthalein16046661
D013448SulfobromophthaleinSLCO1B1 protein results in increased import of Sulfobromophthalein19560444|2239460
D013448SulfobromophthaleinSLCO1B1 protein results in increased susceptibility to Sulfobromophthalein20171238
D013448SulfobromophthaleinSLCO1B1 protein results in increased uptake of Sulfobromophthalein21430235|2312177
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]20171238|2613446
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]21661758
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin Calcium]25106415
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]25106415|2798970
C557331TAK-875TAK-875 inhibits the reaction [SLCO1B1 protein results in increased transport of Bile Acids and Salts]28108665
C557331TAK-875TAK-875 results in decreased activity of SLCO1B1 protein28108665
C011550talinololSLCO1B1 polymorphism affects the susceptibility to talinolol16542205
D013655Taurochenodeoxycholic AcidSLCO1B1 SNP results in increased abundance of Taurochenodeoxycholic Acid22022402
D013656Taurocholic AcidBile Acids and Salts inhibits the reaction [SLCO1B1 protein results in increased uptake of Taurocholic Acid]19464309
D013656Taurocholic AcidRifampin inhibits the reaction [SLCO1B1 protein results in increased import of Taurocholic Acid]16479312
D013656Taurocholic AcidSLCO1B1 protein results in increased import of Taurocholic Acid16479312
D013656Taurocholic AcidSLCO1B1 protein results in increased uptake of Taurocholic Acid19464309
D013656Taurocholic AcidSLCO1B1 SNP results in increased abundance of Taurocholic Acid22022402
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [SLCO1B1 protein results in increased susceptibility to cyanoginosin LR]26134461
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [SLCO1B1 protein results in increased susceptibility to Okadaic Acid]26134461
D013658Taurolithocholic AcidSLCO1B1 SNP results in increased abundance of Taurolithocholic Acid22022402
D013658Taurolithocholic Acid[SLCO1B1 SNP results in increased abundance of Taurolithocholic Acid] which results in increased susceptibility to Simvastatin22022402
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [SLCO1B1 protein results in increased uptake of estrone sulfate]27989701
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of SLCO1B1 protein27989701
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLCO1B1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLCO1B1 mRNA27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [SLCO1B1 protein results in increased import of estrone sulfate]27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLCO1B1 mRNA27450509
C057693troglitazone[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of troglitazone analog19628752
C003330trospium chloridetrospium chloride results in decreased activity of SLCO1B1 protein25466967
D014580Ursodeoxycholic AcidSLCO1B1 protein results in increased uptake of Ursodeoxycholic Acid16534140
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLCO1B1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SLCO1B1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of SLCO1B1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLCO1B1 mRNA26272509
D001335Vehicle EmissionsVehicle Emissions results in decreased activity of SLCO1B1 protein25803276
C059141verlukastverlukast results in decreased activity of SLCO1B1 protein16316932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015125bile acid transmembrane transporter activity-IBA21873635  
GO:0015125bile acid transmembrane transporter activity-TAS-  
GO:0015347sodium-independent organic anion transmembrane transporter activity-IBA21873635  
GO:0015347sodium-independent organic anion transmembrane transporter activity-TAS10358072  
GO:0015349thyroid hormone transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015711organic anion transport-TAS10358072  
GO:0015721bile acid and bile salt transport-IBA21873635  
GO:0015721bile acid and bile salt transport-TAS-  
GO:0043252sodium-independent organic anion transport-IBA21873635  
GO:0043252sodium-independent organic anion transport-TAS-  
GO:0055085transmembrane transport-IEA-  
GO:0070327thyroid hormone transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10358072  
GO:0016020membrane-TAS10358072  
GO:0016323basolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-1643685DiseaseTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619110Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)TAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5661182Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)TAS
R-HSA-879518Transport of organic anionsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23462698Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver. (2013 May)More VRDrug Metab Dispos
23677857Do MDR1 and SLCO1B1 polymorphisms influence the therapeutic response to atorvastatin? A study on a cohort of Egyptian patients with hypercholesterolemia. (2013 Oct)Shabana MFMol Diagn Ther
24343710Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. (2014 May)Nicol MRJ Clin Pharmacol