Gene: PDLIM5

10611
ENH|ENH1|L9|LIM
PDZ and LIM domain 5
protein-coding
4q22.3
Ensembl:ENSG00000163110 MIM:605904 Vega:OTTHUMG00000130973 UniprotKB:Q96HC4
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.627e-3 (AD)  3.351e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FERMT20.917
CYBRD10.915
CPNE30.913
YAP10.911
GNG120.906
S1PR10.904
SDC20.898
HSDL20.897
PPARA0.889
RAB310.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.576
RHO-0.562
CALHM1-0.553
ABCC12-0.552
C2CD4D-0.536
KCNB2-0.529
CDCA5-0.528
ADTRP-0.526
OVOL2-0.524
NRG1-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PDLIM5 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PDLIM5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PDLIM5 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PDLIM5 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PDLIM5 mRNA25458485
D000082AcetaminophenAcetaminophen results in decreased expression of PDLIM5 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PDLIM5 mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of PDLIM5 mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDLIM5 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDLIM5 mRNA20458559
D001280AtrazineAtrazine results in increased expression of PDLIM5 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PDLIM5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDLIM5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDLIM5 mRNA21871943|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDLIM5 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDLIM5 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDLIM5 mRNA"19150397|2001819
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDLIM5 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDLIM5 mRNA]25566086
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDLIM5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PDLIM5 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of PDLIM5 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PDLIM5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDLIM5 gene28505145
D001761BleomycinBleomycin results in increased expression of PDLIM5 protein25933445
C013418bromfenacoumbromfenacoum results in decreased expression of PDLIM5 protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of PDLIM5 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDLIM5 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDLIM5 mRNA24763279
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDLIM5 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of PDLIM5 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of PDLIM5 mRNA15755911
D016572CyclosporineCyclosporine results in increased expression of PDLIM5 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDLIM5 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDLIM5 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PDLIM5 mRNA26924002
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PDLIM5 mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of PDLIM5 mRNA"27840820
D004147DioxinsDioxins affects the expression of PDLIM5 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA24690739
D004237DiuronDiuron results in decreased expression of PDLIM5 mRNA25152437
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of PDLIM5 mRNA21040762
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDLIM5 protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of PDLIM5 mRNA16084531
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDLIM5 mRNA22079256
C540355fenamidonefenamidone results in increased expression of PDLIM5 mRNA27029645
D005419FlavonoidsFlavonoids results in increased expression of PDLIM5 mRNA18035473
D005472FluorouracilPDLIM5 protein affects the susceptibility to Fluorouracil16217747
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDLIM5 mRNA24763279
D017313FenretinideFenretinide results in increased expression of PDLIM5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PDLIM5 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDLIM5 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of PDLIM5 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDLIM5 mRNA27392435
D007854LeadLead affects the expression of PDLIM5 mRNA28903495
C045463leflunomideleflunomide results in increased expression of PDLIM5 mRNA28988120
D018021Lithium ChlorideLithium Chloride results in increased expression of PDLIM5 mRNA15711924
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDLIM5 mRNA26378955
D008558MelphalanMelphalan results in decreased expression of PDLIM5 mRNA22363485
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of PDLIM5 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDLIM5 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PDLIM5 protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PDLIM5 mRNA26924002
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of PDLIM5 mRNA11494140
D009532NickelNickel results in increased expression of PDLIM5 mRNA24768652
C017557nickel subsulfidenickel subsulfide results in increased expression of PDLIM5 mRNA21086188
C006253pirinixic acidpirinixic acid results in decreased expression of PDLIM5 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of PDLIM5 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDLIM5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDLIM5 mRNA22079256|2271453
C005556propionaldehydepropionaldehyde results in increased expression of PDLIM5 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PDLIM5 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDLIM5 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of PDLIM5 gene28589171
D053260SootSoot results in increased expression of PDLIM5 mRNA26551751
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of PDLIM5 mRNA16214533
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDLIM5 mRNA26378955
D013739TestosteroneTestosterone results in decreased expression of PDLIM5 mRNA21669218
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDLIM5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDLIM5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDLIM5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDLIM5 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDLIM5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDLIM5 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDLIM5 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PDLIM5 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PDLIM5 mRNA20133372
C483909torcetrapibtorcetrapib results in increased expression of PDLIM5 mRNA23228038
D014212TretinoinTretinoin results in increased expression of PDLIM5 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PDLIM5 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of PDLIM5 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PDLIM5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PDLIM5 mRNA28973697
D014520UrethaneUrethane results in increased expression of PDLIM5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDLIM5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PDLIM5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDLIM5 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of PDLIM5 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of PDLIM5 mRNA15901671
D014638VanadatesVanadates results in increased expression of PDLIM5 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of PDLIM5 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-ISS-  
GO:0005080protein kinase C binding-ISS-  
GO:0005515protein binding-IPI16549780  25416956  
GO:0042805actinin binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0047485protein N-terminus binding-IEA-  
GO:0098641cadherin binding involved in cell-cell adhesion-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0051963regulation of synapse assembly-ISS-  
GO:0061001regulation of dendritic spine morphogenesis-ISS-  
GO:0061049cell growth involved in cardiac muscle cell development-ISS-  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-ISS-  
GO:0005913cell-cell adherens junction-HDA25468996  
GO:0014069postsynaptic density-ISS-  
GO:0015629actin cytoskeleton-IDA-  
GO:0016020membrane-ISS-  
GO:0043005neuron projection-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (2014 Jan)Gelernter JMol Psychiatry
27693979Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. (2017 Jan)Owusu DJ Psychiatr Res
27350677Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. (2016 Jun)Wang KSJ Genet
22449891Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. (2012 Jun)Wong MLMol Psychiatry