Gene: TGOLN2

10618
TGN38|TGN46|TGN48|TGN51|TTGN2
trans-golgi network protein 2
protein-coding
2p11.2
Ensembl:ENSG00000152291 MIM:603062 Vega:OTTHUMG00000153017 UniprotKB:O43493
NG_030379.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.076e-1 (AD)  1.455e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERINC30.942
SUPT16H0.931
NOLC10.93
ARMCX30.928
GOLGA20.926
FAM168B0.926
APP0.925
HECTD10.922
SRP720.922
YLPM10.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.661
OR4F5-0.639
MTRNR2L6-0.298
MTRNR2L10-0.294
PLA2G5-0.293
MTRNR2L9-0.276
PON3-0.265
EYA2-0.263
OR4F16-0.249
S100A14-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of TGOLN2 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of TGOLN2 mRNA23397585
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TGOLN2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of TGOLN2 mRNA20458559
D001554BenzeneBenzene results in decreased expression of TGOLN2 mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TGOLN2 mRNA22342234
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGOLN2 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of TGOLN2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TGOLN2 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of TGOLN2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of TGOLN2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TGOLN2 mRNA23397585
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TGOLN2 protein24527689
D002994ClofibrateClofibrate results in increased expression of TGOLN2 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of TGOLN2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TGOLN2 mRNA25562108
D004117DimethoateDimethoate results in increased expression of TGOLN2 mRNA23397585
C038939enzacameneenzacamene results in increased expression of TGOLN2 mRNA23397585
D018120FinasterideFinasteride results in increased expression of TGOLN2 mRNA24136188
D005480FlurbiprofenFlurbiprofen results in increased expression of TGOLN2 mRNA16949054
D005839GentamicinsGentamicins results in increased expression of TGOLN2 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of TGOLN2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGOLN2 mRNA25613284
C045463leflunomideleflunomide results in increased expression of TGOLN2 mRNA24136188
C521938LM11 compoundLM11 compound affects the localization of TGOLN2 protein17563369
D008713MethimazoleMethimazole results in increased expression of TGOLN2 mRNA23397585
D008731MethoxychlorMethoxychlor results in decreased expression of TGOLN2 mRNA23397585
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of TGOLN2 mRNA28349193
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TGOLN2 mRNA23397585
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TGOLN2 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of TGOLN2 mRNA15674844
C029938nickel sulfatenickel sulfate results in decreased expression of TGOLN2 mRNA18651567
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of TGOLN2 mRNA23397585
D010126OzoneOzone results in increased expression of TGOLN2 mRNA12763052
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TGOLN2 mRNA18804290
C006253pirinixic acidpirinixic acid results in increased expression of TGOLN2 mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of TGOLN2 mRNA]20059764
D011374ProgesteroneProgesterone results in increased expression of TGOLN2 mRNA23012394
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TGOLN2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of TGOLN2 mRNA22431001
D012969Sodium FluorideSodium Fluoride results in decreased expression of TGOLN2 protein28918527
D053260SootSoot results in increased expression of TGOLN2 mRNA22461453
D014284TriiodothyronineTriiodothyronine results in decreased expression of TGOLN2 mRNA23397585
D014284TriiodothyronineTriiodothyronine results in increased expression of TGOLN2 mRNA23397585
C061133tamibarotenetamibarotene affects the expression of TGOLN2 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of TGOLN2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TGOLN2 mRNA23397585
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TGOLN2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TGOLN2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TGOLN2 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of TGOLN2 mRNA23228038
D014212TretinoinTretinoin affects the expression of TGOLN2 mRNA15498508
D014501UraniumUranium affects the expression of TGOLN2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TGOLN2 mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of TGOLN2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of TGOLN2 mRNA17292431|1796380
C025643vinclozolinvinclozolin affects the expression of TGOLN2 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TGOLN2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of TGOLN2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  25416956  29568061  
GO ID GO Term Qualifier Evidence PubMed
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005768endosome-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IDA22797923  27435297  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005802trans-Golgi network-IDA18166528  22456507  23386608  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030133transport vesicle-TAS9422759  
GO:0030140trans-Golgi network transport vesicle-IBA21873635  
GO:0030665clathrin-coated vesicle membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20468057Case-control association study of TGOLN2 in attempted suicide. (2010 Jul)Mahon PBAm J Med Genet B Neuropsychiatr Genet