Gene: MYL12A

10627
HEL-S-24|MLC-2B|MLCB|MRCL3|MRLC3|MYL2B
myosin light chain 12A
protein-coding
18p11.31
Ensembl:ENSG00000101608 Vega:OTTHUMG00000131509 UniprotKB:P19105
NC_000018.10
SNP Mapped
3   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.948e-1 (AD)  4.710e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs61751192chr18:3253944 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs13381416chr18:3251835 (GRCh38.p7)A>Gcocaine dependenceSNV(Single Nucleotide Variation)
rs79794368chr18:3249131 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAGLN20.925
CLIC10.916
PSMB80.906
ANXA50.902
B2M0.899
S100A110.893
MSN0.888
ANXA20.885
RHOC0.884
SRGN0.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.579
ABCC12-0.578
CALHM1-0.577
SLC7A4-0.568
NEUROD6-0.559
KCNB2-0.559
CHRNB2-0.545
PPEF1-0.542
ADRA1D-0.542
GRIN2B-0.542

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB083784-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MYL12A gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MYL12A mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYL12A mRNA16483693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MYL12A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYL12A mRNA17879257
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYL12A mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of MYL12A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of MYL12A protein24909818
C006780bisphenol Abisphenol A results in increased expression of MYL12A protein24909818
C006780bisphenol Abisphenol A affects the expression of MYL12A mRNA25181051
D000069286BortezomibBortezomib results in increased expression of MYL12A mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MYL12A mRNA18804290
D002104CadmiumCadmium results in increased expression of MYL12A mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MYL12A mRNA18804290
C043211carvedilolcarvedilol results in decreased expression of MYL12A protein20403466
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MYL12A mRNA18804290
C100187chloropicrinchloropicrin results in increased expression of MYL12A mRNA26352163
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of MYL12A mRNA15467011
D003474CurcuminCurcumin results in increased expression of MYL12A mRNA17999991
D016572CyclosporineCyclosporine results in increased expression of MYL12A mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MYL12A mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MYL12A mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYL12A mRNA20823114
D002945CisplatinCisplatin results in increased expression of MYL12A mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of MYL12A mRNA28302478
D004317DoxorubicinDoxorubicin affects the expression of MYL12A protein29385562
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYL12A mRNA17108234
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MYL12A mRNA23649840
C540355fenamidonefenamidone results in increased expression of MYL12A mRNA27029645
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of MYL12A protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of MYL12A protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of MYL12A protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MYL12A protein23178681
C410337K 7174K 7174 results in increased expression of MYL12A mRNA24086573
C045463leflunomideleflunomide results in increased expression of MYL12A mRNA28988120
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYL12A mRNA20823114
D008727MethotrexateMethotrexate results in increased expression of MYL12A mRNA21678067
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of MYL12A mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MYL12A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MYL12A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYL12A mRNA"25554681
D009532NickelNickel results in increased expression of MYL12A mRNA24768652
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MYL12A mRNA18804290
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MYL12A mRNA27029645
D011794QuercetinQuercetin results in increased expression of MYL12A mRNA21632981
D010042OuabainOuabain results in increased expression of MYL12A protein17268060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MYL12A promoter]19654925
C483909torcetrapibtorcetrapib results in increased expression of MYL12A mRNA23228038
D014635Valproic AcidValproic Acid results in increased expression of MYL12A mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MYL12A gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI14743216  17353931  21457715  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO:0070527platelet aggregation-HMP23382103  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016459myosin complex-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-373755Semaphorin interactionsIEA
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928664Ephrin signalingTAS
R-HSA-397014Muscle contractionTAS
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-5625740RHO GTPases activate PKNsIEA
R-HSA-5625900RHO GTPases activate CITIEA
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-5627123RHO GTPases activate PAKsIEA
R-HSA-5627123RHO GTPases activate PAKsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal