Gene info: ID 10628

Gene: TXNIP

GENE ID: 10628

Synonyms: ARRDC6|EST01027|HHCPA78|THIF|VDUP1

Description: thioredoxin interacting protein

Gene type: protein-coding

Location: 1q21.1

dbXrefs: Ensembl:ENSG00000265972 MIM:606599 Vega:OTTHUMG00000013755 UniprotKB:Q9H3M7

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.902e-1 (AD) 7.483e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19693031	chr1:145441552	TXNIP		1.020e-11	Alcohol consumption der day	27843151

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CALCOCO2	0.82
PTTG1IP	0.813
WASF2	0.812
STOM	0.81
BNIP2	0.809
LEPROT	0.808
CPNE3	0.798
PDK4	0.794
VIM	0.794
USP3	0.789

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.524
FBLN7	-0.515
MCHR1	-0.504
PIP5KL1	-0.502
CALHM1	-0.5
AGMAT	-0.494
RTP1	-0.493
SLC7A4	-0.483
GABRG3	-0.483
SLC32A1	-0.483

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C097949	1,25-dihydroxyvitamin D	"1,25-dihydroxyvitamin D results in increased expression of TXNIP mRNA"	16061374
C081014	1,2-bis(2,4,6-tribromophenoxy)ethane	"1,2-bis(2,4,6-tribromophenoxy)ethane results in increased expression of TXNIP mRNA"	28249227
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of TXNIP mRNA"	19162173
C558048	1,7-diphenyl-4,6-heptadien-3-ol	"1,7-diphenyl-4,6-heptadien-3-ol results in decreased expression of TXNIP mRNA"	25575267
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TXNIP mRNA	28329830
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of TXNIP mRNA"	20638727
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TXNIP mRNA"	21346803
C012796	2-butenal	2-butenal results in decreased expression of TXNIP mRNA	20471460
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of TXNIP mRNA"	20206263
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TXNIP mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TXNIP mRNA"	19692669
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of TXNIP mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C477187	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole	"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of TXNIP mRNA"	22745752
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]"	29031535
C114369	7,8-diacetoxy-4-methylcoumarin	"7,8-diacetoxy-4-methylcoumarin results in decreased expression of TXNIP mRNA"	24103856
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TXNIP mRNA"	19936915
D000082	Acetaminophen	Acetaminophen affects the expression of TXNIP mRNA	25704631
D000082	Acetaminophen	Acetaminophen results in decreased expression of TXNIP mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of TXNIP mRNA	17562736
D000255	Adenosine Triphosphate	Adenosine Triphosphate results in increased activity of TXNIP mRNA	21832250
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TXNIP protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TXNIP mRNA	21632981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TXNIP mRNA	19770486
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]	29031535
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of TXNIP mRNA	21757418
D000393	Air Pollutants	Air Pollutants results in decreased expression of TXNIP mRNA	21757418
D000447	Aldehydes	Aldehydes results in decreased expression of TXNIP mRNA	25014914
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]	24491314
D000493	Allopurinol	Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]	23647015
D000493	Allopurinol	Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]	23647015
C002055	allose	[allose co-treated with Fluorouracil] results in increased expression of TXNIP protein	18930000
C002055	allose	allose results in increased expression of TXNIP mRNA	18930000
C002055	allose	allose results in increased expression of TXNIP protein	18930000
C002055	allose	Fluorouracil promotes the reaction [allose results in increased expression of TXNIP mRNA]	18930000
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of TXNIP mRNA	28522335
C103505	AM 251	AM 251 results in increased expression of TXNIP mRNA	16500647
D000841	Anisomycin	Anisomycin results in increased expression of TXNIP mRNA	10843682
D000872	Anthocyanins	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of TXNIP protein]	24795233
D001151	Arsenic	Arsenic affects the methylation of TXNIP gene	25304211
C058317	arsenic disulfide	arsenic disulfide affects the expression of TXNIP mRNA	16562669
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TXNIP mRNA	15725085\|1823173
D017638	Asbestos, Crocidolite	"[Asbestos, Crocidolite results in increased oxidation of TXN protein] inhibits the reaction [TXN protein binds to TXNIP protein]"	24885895
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of TXNIP mRNA	15372504
D001280	Atrazine	Atrazine results in increased expression of TXNIP mRNA	22378314
D001379	Azathioprine	Azathioprine results in increased expression of TXNIP mRNA	19192274
C547126	AZM551248	AZM551248 results in decreased expression of TXNIP mRNA	22323515
C038044	baicalin	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]"	29031535
C038044	baicalin	baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]	29031535
C004456	beauvericin	beauvericin results in increased expression of TXNIP mRNA	29203277
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNA	17905399
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TXNIP mRNA	17879257\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TXNIP mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TXNIP mRNA	22228805\|2719552
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TXNIP mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of TXNIP mRNA	19619570\|2118537
D004958	Estradiol	Estradiol results in decreased expression of TXNIP mRNA	25575267
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of TXNIP mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of TXNIP mRNA	25912373
C006780	bisphenol A	bisphenol A results in increased expression of TXNIP mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of TXNIP mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of TXNIP mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of TXNIP mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TXNIP mRNA	14729362\|1500399
D020122	tert-Butylhydroperoxide	TXNIP protein results in decreased susceptibility to tert-Butylhydroperoxide	15003993
C018475	butyraldehyde	butyraldehyde results in increased expression of TXNIP mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in increased expression of TXNIP mRNA	12800193
C584509	C646 compound	C646 compound results in increased expression of TXNIP mRNA	26191083
D002220	Carbamazepine	Carbamazepine affects the expression of TXNIP mRNA	25979313
C100187	chloropicrin	chloropicrin affects the expression of TXNIP mRNA	26352163
C023676	chloroquine diphosphate	chloroquine diphosphate results in increased expression of TXNIP mRNA	19192274
D002922	Ciguatoxins	Ciguatoxins affects the expression of TXNIP mRNA	18353800
D002994	Clofibrate	Clofibrate results in decreased expression of TXNIP mRNA	17585979\|2527062
D002994	Clofibrate	Clofibrate results in increased expression of TXNIP mRNA	23811191
D002994	Clofibrate	Clofibrate results in increased expression of TXNIP mRNA	12851107
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TXNIP mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TXNIP mRNA	21139344
D005576	Colforsin	Colforsin results in increased activity of TXNIP mRNA	21832250
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of TXNIP mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TXNIP mRNA	19549813
D016572	Cyclosporine	Cyclosporine affects the expression of TXNIP mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of TXNIP mRNA	19159671
D016572	Cyclosporine	Cyclosporine results in increased expression of TXNIP mRNA	21632981\|2214713
D016572	Cyclosporine	Cyclosporine results in increased expression of TXNIP protein	22147139
D016572	Cyclosporine	U 0126 inhibits the reaction [Cyclosporine results in increased expression of TXNIP protein]	22147139
D016572	Cyclosporine	Cyclosporine results in increased expression of TXNIP mRNA	25270620
C017160	cypermethrin	cypermethrin results in increased expression of TXNIP mRNA	21142847
D000069439	Dasatinib	Dasatinib results in increased expression of TXNIP mRNA	20579391
C014347	decitabine	decitabine affects the expression of TXNIP mRNA	23300844
C014347	decitabine	decitabine results in increased expression of TXNIP mRNA	19194470
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of TXNIP protein	20195491
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of TXNIP protein	20195491
D003703	Demecolcine	Demecolcine results in increased expression of TXNIP mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in increased expression of TXNIP mRNA	12782123
D003907	Dexamethasone	Dexamethasone results in increased expression of TXNIP mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TXNIP mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TXNIP mRNA	28962523
D002945	Cisplatin	Cisplatin affects the expression of TXNIP mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TXNIP mRNA	27392435
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TXNIP mRNA]	21858171
D002945	Cisplatin	Cisplatin results in increased expression of TXNIP mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of TXNIP mRNA	21151649
D004008	Diclofenac	Diclofenac results in increased expression of TXNIP mRNA	19192274
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TXNIP mRNA]"	19467301
D004041	Dietary Fats	Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of TXNIP protein]	24795233
D004041	Dietary Fats	Dietary Fats results in increased expression of TXNIP mRNA	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of TXNIP protein	24795233
C014476	diethyl maleate	diethyl maleate results in increased expression of TXNIP mRNA	21161181
C115058	difenoconazole	difenoconazole results in decreased expression of TXNIP mRNA	28263823
D002117	Calcitriol	Calcitriol promotes the reaction [TXNIP protein binds to TRN protein]	10843682
D002117	Calcitriol	[Calcitriol promotes the reaction [TXNIP protein binds to TRN protein]] which results in increased activity of MAP3K5 protein	10843682
D002117	Calcitriol	Calcitriol results in decreased expression of TXNIP mRNA	16002434
D002117	Calcitriol	Calcitriol results in increased expression of TXNIP mRNA	10843682
D004317	Doxorubicin	Doxorubicin results in decreased expression of TXNIP mRNA	24885895
D004317	Doxorubicin	MAPK1 inhibits the reaction [Doxorubicin results in decreased expression of TXNIP mRNA]	24885895
D004317	Doxorubicin	Doxorubicin affects the expression of TXNIP mRNA	16243910
C118739	entinostat	entinostat results in decreased expression of TXNIP mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C551471	EPI 001	EPI 001 results in increased expression of TXNIP mRNA	25669987
D004964	Estriol	Estriol results in decreased expression of TXNIP mRNA	25575267
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TXNIP mRNA	17351261
D019830	Adenosine-5'-(N-ethylcarboxamide)	Adenosine-5'-(N-ethylcarboxamide) results in increased activity of TXNIP mRNA	21832250
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TXNIP mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of TXNIP protein	18270325
D011345	Fenofibrate	Fenofibrate results in increased expression of TXNIP mRNA	25572481
D011345	Fenofibrate	Fenofibrate results in increased expression of TXNIP mRNA	17264098
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of TXNIP mRNA	16197558
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in decreased expression of TXNIP protein	15834431
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased methylation of TXNIP promoter	15834431
D005411	Flame Retardants	Flame Retardants results in decreased expression of TXNIP mRNA	19858236
D005411	Flame Retardants	Flame Retardants results in decreased expression of TXNIP protein	19858236
C024352	fludarabine	[LAQ824 co-treated with fludarabine] results in increased expression of TXNIP protein	18852132
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of TXNIP mRNA	28329830
C007738	fluoranthene	fluoranthene results in decreased expression of TXNIP mRNA	28329830
D005472	Fluorouracil	[allose co-treated with Fluorouracil] results in increased expression of TXNIP protein	18930000
D005472	Fluorouracil	Fluorouracil promotes the reaction [allose results in increased expression of TXNIP mRNA]	18930000
D005472	Fluorouracil	Fluorouracil results in increased expression of TXNIP mRNA	18930000
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of TXNIP mRNA]	15016801
D005472	Fluorouracil	TXNIP protein affects the susceptibility to Fluorouracil	15548681
C061365	flusilazole	flusilazole results in decreased expression of TXNIP mRNA	28263823
D005485	Flutamide	Flutamide results in decreased expression of TXNIP mRNA	24136188
D005492	Folic Acid	Folic Acid results in increased expression of TXNIP mRNA	11723236
D005557	Formaldehyde	Formaldehyde results in increased expression of TXNIP mRNA	23649840
D005632	Fructose	Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]	24491314
D005632	Fructose	Fructose results in increased expression of TXNIP protein	24491314
D005632	Fructose	Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]	24491314
C069837	fullerene C60	fullerene C60 results in decreased expression of TXNIP mRNA	19167457
C039281	furan	furan results in increased methylation of TXNIP gene	22079235
C106014	gedunin	gedunin results in decreased expression of TXNIP mRNA	17010675
D005839	Gentamicins	Gentamicins results in increased expression of TXNIP mRNA	22061828
D005944	Glucosamine	Glucosamine promotes the reaction [TXNIP results in increased abundance of Reactive Oxygen Species]	17178593
D005944	Glucosamine	Glucosamine results in increased expression of TXNIP mRNA	17178593
D005944	Glucosamine	Glucosamine results in increased expression of TXNIP protein	17178593
D005944	Glucosamine	TXNIP promotes the reaction [Glucosamine results in increased expression of LAMB1 mRNA]	17178593
D005944	Glucosamine	TXNIP promotes the reaction [Glucosamine results in increased expression of LAMC1 mRNA]	17178593
D005944	Glucosamine	Glucosamine results in increased expression of TXNIP protein	17178593
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D005947	Glucose	Glucose deficiency results in decreased expression of TXNIP mRNA	20195491
D005947	Glucose	Glucose deficiency results in decreased expression of TXNIP protein	20195491
D005947	Glucose	Glucose results in increased expression of TXNIP protein	23647015
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein]	23647015
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]	23647015
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in increased expression of TXNIP protein]	23647015\|2364701
D005947	Glucose	TXNIP mRNA results in increased susceptibility to Glucose	23647015
D005947	Glucose	Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]	26660634
D005947	Glucose	[Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein	26660634
D005947	Glucose	Glucose promotes the reaction [TXNIP results in increased abundance of Reactive Oxygen Species]	17178593
D005947	Glucose	[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA	26660634
D005947	Glucose	[[[[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA] which results in increased expression of TXNIP protein] promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein	26660634\|2666063
D005947	Glucose	[Glucose results in decreased expression of MIR17 mRNA] which results in increased stability of TXNIP protein	26660634
D005947	Glucose	Glucose results in increased expression of TXNIP mRNA	17178593\|2286958
D005947	Glucose	Glucose results in increased expression of TXNIP protein	17178593
D005947	Glucose	[NFE2L2 protein binds to TXNIP promoter] inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]	22869588\|2286958
D005947	Glucose	NFE2L2 protein inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]	22869588
D005947	Glucose	TXNIP promotes the reaction [Glucose results in increased expression of FN1 mRNA]	17178593
D005947	Glucose	TXNIP promotes the reaction [Glucose results in increased expression of LAMB1 mRNA]	17178593
D005947	Glucose	TXNIP promotes the reaction [Glucose results in increased expression of LAMB2 mRNA]	17178593
D005947	Glucose	TXNIP promotes the reaction [Glucose results in increased expression of LAMB3 mRNA]	17178593
D005947	Glucose	TXNIP promotes the reaction [Glucose results in increased expression of LAMC1 mRNA]	17178593
D005947	Glucose	Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D005947	Glucose	Glucose results in increased activity of TXNIP mRNA	21832250
D005947	Glucose	Glucose results in increased expression of TXNIP protein	17178593\|2364701
D005947	Glucose	Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D005947	Glucose	rhodioloside inhibits the reaction [Glucose results in increased expression of TXNIP protein]	29031534
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein]	23647015
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in increased expression of CASP1 protein]	23647015
D005947	Glucose	TXNIP mRNA promotes the reaction [Glucose results in increased expression of TXNIP protein]	23647015\|2364701
D005947	Glucose	TXNIP mRNA results in increased susceptibility to Glucose	23647015
D005947	Glucose	TXNIP protein affects the reaction [Glucose results in increased expression of COL4A3BP mRNA]	29031534
D005947	Glucose	TXNIP protein affects the reaction [Glucose results in increased expression of FN1 mRNA]	29031534
D005947	Glucose	TXNIP protein affects the reaction [Glucose results in increased expression of FN1 protein]	29031534
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in increased expression of TXNIP mRNA	19192274
D017313	Fenretinide	Fenretinide results in decreased expression of TXNIP mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TXNIP mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TXNIP mRNA	10843682
D006861	Hydrogen Peroxide	TXNIP promotes the reaction [Hydrogen Peroxide results in increased activity of MAPK8 protein]	10843682
D006861	Hydrogen Peroxide	TXNIP promotes the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]	10843682
D006861	Hydrogen Peroxide	TXNIP results in increased susceptibility to Hydrogen Peroxide	10843682
C492448	ICG 001	ICG 001 results in increased expression of TXNIP mRNA	26191083
D007213	Indomethacin	Indomethacin results in decreased expression of TXNIP mRNA	16984733
D015759	Ionomycin	Ionomycin results in decreased expression of TXNIP mRNA	10843682
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TXNIP mRNA	25613284
C051890	irinotecan	irinotecan results in increased expression of TXNIP mRNA	20185912
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TXNIP mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of TXNIP mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of TXNIP protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TXNIP mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TXNIP mRNA	21949397\|2530787
D007649	Ketamine	Ketamine results in increased expression of TXNIP mRNA	20080153
C477361	LAQ824	[LAQ824 co-treated with fludarabine] results in increased expression of TXNIP protein	18852132
C477361	LAQ824	LAQ824 results in increased expression of TXNIP protein	18852132
C008261	lead acetate	lead acetate results in decreased expression of TXNIP mRNA	22641619
C052901	lemongrass oil	lemongrass oil affects the expression of TXNIP mRNA	25976427
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TXNIP mRNA	26582142
D008727	Methotrexate	Methotrexate results in increased expression of TXNIP mRNA	19192274
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TXNIP mRNA	23179753\|2800136
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNA	17905399
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TXNIP mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TXNIP mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TXNIP mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TXNIP mRNA	17475336\|1806909
D008775	Methylprednisolone	Methylprednisolone results in increased expression of TXNIP mRNA	19192274
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of TXNIP mRNA	21195148
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of TXNIP mRNA	21195148
C500085	muraglitazar	muraglitazar results in increased expression of TXNIP mRNA	21515302
C064769	N-acetylsphingosine	N-acetylsphingosine results in increased expression of TXNIP protein	18270325
C064769	N-acetylsphingosine	TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]	18270325
C064769	N-acetylsphingosine	TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]	18270325
C064769	N-acetylsphingosine	TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]	18270325
C064769	N-acetylsphingosine	N-acetylsphingosine results in increased expression of TXNIP mRNA	18270325
C064769	N-acetylsphingosine	N-acetylsphingosine results in increased expression of TXNIP protein	18270325
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TXNIP mRNA"	25102311
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TXNIP mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TXNIP mRNA"	25554681
D009281	Naphthalenes	Naphthalenes results in decreased expression of TXNIP protein	17337753
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of TXNIP mRNA	20551477
C022838	nickel chloride	nickel chloride results in increased expression of TXNIP mRNA	17312168
C029938	nickel sulfate	nickel sulfate results in decreased expression of TXNIP mRNA	22714537
D009538	Nicotine	Nicotine results in increased expression of TXNIP mRNA	17456735
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of TXNIP mRNA	17616710
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TXNIP mRNA"	19013360
C008661	nobiletin	nobiletin results in decreased expression of TXNIP mRNA	23321314
C008661	nobiletin	nobiletin results in decreased expression of TXNIP protein	23321314
C008661	nobiletin	nobiletin results in decreased expression of TXNIP mRNA	23321314
C008661	nobiletin	nobiletin results in decreased expression of TXNIP protein	23321314
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of TXNIP mRNA	20971185
C558013	NSC 689534	NSC 689534 results in increased expression of TXNIP mRNA	20971185
C507134	ON 01910	ON 01910 results in increased expression of TXNIP mRNA	22351695
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of TXNIP mRNA"	19371625
D010100	Oxygen	Oxygen deficiency results in increased expression of TXNIP mRNA	20880076
D019308	Palmitic Acid	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]"	29031535
D019308	Palmitic Acid	AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]	29031535
D019308	Palmitic Acid	baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]	29031535
D019308	Palmitic Acid	Palmitic Acid results in increased expression of TXNIP protein	29031535
D010269	Paraquat	TXNIP protein results in increased susceptibility to Paraquat	12054598
D010269	Paraquat	Paraquat results in increased expression of TXNIP protein	29054699
D010269	Paraquat	Silymarin inhibits the reaction [Paraquat results in increased expression of TXNIP protein]	29054699
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in decreased expression of TXNIP mRNA	19095052
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TXNIP mRNA	19858236\|2670570
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TXNIP protein	19858236
C033094	perfluorobutyric acid	perfluorobutyric acid results in decreased expression of TXNIP mRNA	23567314
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of TXNIP mRNA	23567314
C522391	perfluorododecanoic acid	perfluorododecanoic acid affects the expression of TXNIP mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid affects the expression of TXNIP mRNA	23567314
C479228	perfluorohexanoic acid	perfluorohexanoic acid results in increased expression of TXNIP mRNA	23567314
C101815	perfluoro-n-heptanoic acid	perfluoro-n-heptanoic acid results in increased expression of TXNIP mRNA	23567314
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of TXNIP mRNA	23567314
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid affects the expression of TXNIP mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of TXNIP mRNA	23567314
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TXNIP protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TXNIP mRNA	23567314
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TXNIP mRNA	16221955\|2851185
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TXNIP mRNA	26794494
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of TXNIP mRNA	26678675
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TXNIP mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TXNIP mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of TXNIP mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TXNIP mRNA"	27188386
C006253	pirinixic acid	pirinixic acid results in increased expression of TXNIP mRNA	17426115\|1830175
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of TXNIP mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of TXNIP mRNA	21858171
D010894	Piroxicam	Piroxicam results in increased expression of TXNIP mRNA	19192274
D010936	Plant Extracts	Plant Extracts results in increased expression of TXNIP mRNA	21297082
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TXNIP protein	23718831
D011239	Prednisolone	Prednisolone results in increased expression of TXNIP mRNA	19192274
D011374	Progesterone	Progesterone results in decreased expression of TXNIP mRNA	18037150
D011374	Progesterone	Progesterone results in decreased expression of TXNIP mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of TXNIP mRNA	21278054
C045950	propiconazole	propiconazole results in decreased expression of TXNIP mRNA	28970091
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TXNIP mRNA	24780913
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of TXNIP mRNA	25626140
C010313	pseudocumene	pseudocumene results in decreased expression of TXNIP protein	17337753
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D011794	Quercetin	Quercetin results in decreased expression of TXNIP mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [Fructose results in increased expression of TXNIP protein]	24491314
D011794	Quercetin	Quercetin inhibits the reaction [Glucose results in increased expression of TXNIP protein]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]	23647015
D011794	Quercetin	Quercetin inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]	23647015
D015125	Oxyquinoline	Oxyquinoline results in increased expression of TXNIP mRNA	21632981
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA	19059307
D017382	Reactive Oxygen Species	Glucosamine promotes the reaction [TXNIP results in increased abundance of Reactive Oxygen Species]	17178593
D017382	Reactive Oxygen Species	Glucose promotes the reaction [TXNIP results in increased abundance of Reactive Oxygen Species]	17178593
D017382	Reactive Oxygen Species	TXNIP results in increased abundance of Reactive Oxygen Species	17178593
D017382	Reactive Oxygen Species	TXNIP protein promotes the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]	15123525
C059514	resveratrol	resveratrol results in decreased expression of TXNIP mRNA	19371625
C059514	resveratrol	resveratrol results in decreased expression of TXNIP protein	20195491
C059514	resveratrol	resveratrol results in increased expression of TXNIP protein	20195491
C059514	resveratrol	resveratrol results in decreased expression of TXNIP protein	20195491
C059514	resveratrol	resveratrol results in decreased expression of TXNIP protein	20195491
C059514	resveratrol	resveratrol results in increased expression of TXNIP protein	20195491
C009172	rhodioloside	rhodioloside inhibits the reaction [Glucose results in increased expression of TXNIP protein]	29031534
C089730	rosiglitazone	rosiglitazone results in increased expression of TXNIP mRNA	21515302
D012402	Rotenone	Rotenone results in decreased expression of TXNIP mRNA	24810058
D012402	Rotenone	Rotenone results in increased expression of TXNIP mRNA	19013527
C078903	seocalcitol	seocalcitol results in increased expression of TXNIP mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog affects the expression of TXNIP mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TXNIP mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of TXNIP mRNA	23623845
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TXNIP mRNA	22300531\|2535159
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of TXNIP mRNA	19073995
D012834	Silver	Silver results in decreased expression of TXNIP mRNA	26014281
D012834	Silver	Silver results in increased expression of TXNIP mRNA	19429238\|2257657
D012838	Silymarin	Silymarin inhibits the reaction [Paraquat results in increased expression of TXNIP protein]	29054699
C009277	sodium arsenate	sodium arsenate results in increased expression of TXNIP mRNA	16882884
D053260	Soot	Soot affects the expression of TXNIP mRNA	26551751
D013311	Streptozocin	Streptozocin results in increased expression of TXNIP mRNA	17582205
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]	23647015
D013311	Streptozocin	Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]	23647015
D013311	Streptozocin	Quercetin inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]	23647015
D013311	Streptozocin	Streptozocin results in increased expression of TXNIP mRNA	23647015
D013311	Streptozocin	Streptozocin results in increased expression of TXNIP protein	23647015
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA	19059307
D013629	Tamoxifen	Tamoxifen affects the expression of TXNIP mRNA	20937368
C501413	tesaglitazar	tesaglitazar results in increased expression of TXNIP mRNA	21515302
C004648	testosterone enanthate	testosterone enanthate affects the expression of TXNIP mRNA	17440010
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TXNIP mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TXNIP mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TXNIP mRNA	19619570\|1969266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TXNIP mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TXNIP mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TXNIP mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TXNIP mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TXNIP mRNA	21215274
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of TXNIP mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TXNIP mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of TXNIP mRNA	27188386
D013853	Thioacetamide	[TXNIP gene mutant form co-treated with Thioacetamide] results in increased expression of BCL2 protein	20713078
D013853	Thioacetamide	TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased activity of CASP3 protein]	20713078
D013853	Thioacetamide	TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased activity of CASP9 protein]	20713078
D013853	Thioacetamide	TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased expression of BAX protein]	20713078
D013853	Thioacetamide	TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]	20713078
D013853	Thioacetamide	TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein]	20713078
D013853	Thioacetamide	TXNIP protein results in increased susceptibility to Thioacetamide	20713078
C009495	titanium dioxide	titanium dioxide results in increased expression of TXNIP mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in decreased expression of TXNIP mRNA	20920546
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TXNIP mRNA	28065790
D019772	Topotecan	TXNIP protein affects the susceptibility to Topotecan	16217747
C011559	tributyltin	tributyltin results in increased expression of TXNIP mRNA	21683754
D014241	Trichloroethylene	Trichloroethylene results in increased expression of TXNIP mRNA	25549359\|2897337
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TXNIP mRNA	17905399
C012589	trichostatin A	trichostatin A affects the expression of TXNIP mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of TXNIP mRNA	15901671
C050414	tripterine	tripterine results in decreased expression of TXNIP mRNA	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TXNIP mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of TXNIP mRNA	25572481\|2566998
C057693	troglitazone	troglitazone results in decreased expression of TXNIP mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of TXNIP mRNA	21515302
C113580	U 0126	U 0126 inhibits the reaction [Cyclosporine results in increased expression of TXNIP protein]	22147139
C113580	U 0126	U 0126 results in decreased expression of TXNIP protein	22147139
D014520	Urethane	Urethane results in increased expression of TXNIP mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of TXNIP mRNA	25979313\|2607246
D014635	Valproic Acid	Valproic Acid results in decreased expression of TXNIP mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of TXNIP mRNA	28001369
D014635	Valproic Acid	Valproic Acid affects the expression of TXNIP mRNA	26072468
D014635	Valproic Acid	Valproic Acid results in increased expression of TXNIP mRNA	15799026\|2054688
D014635	Valproic Acid	Valproic Acid results in increased expression of TXNIP mRNA	15901671
C025643	vinclozolin	vinclozolin affects the expression of TXNIP mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of TXNIP mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of TXNIP mRNA	23649840
D002762	Cholecalciferol	Cholecalciferol results in increased expression of TXNIP mRNA	24451003
D002762	Cholecalciferol	Cholecalciferol results in increased expression of TXNIP protein	20713078\|2445100
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TXNIP mRNA	20044591
C111237	vorinostat	vorinostat results in increased expression of TXNIP mRNA	17218635
D014873	Water Pollutants	Water Pollutants results in decreased expression of TXNIP mRNA	23591932
C088658	zoledronic acid	zoledronic acid results in increased expression of TXNIP mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004857	enzyme inhibitor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	10814541 14632196 23880345 26919541
GO:0031625	ubiquitin protein ligase binding	-	IPI	20068034

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006606	protein import into nucleus	-	IEA	-
GO:0007049	cell cycle	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0009749	response to glucose	-	IEA	-
GO:0030216	keratinocyte differentiation	-	IDA	14632196
GO:0032355	response to estradiol	-	IEA	-
GO:0032570	response to progesterone	-	IEA	-
GO:0042127	regulation of cell proliferation	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043086	negative regulation of catalytic activity	-	IEA	-
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IEA	-
GO:0051592	response to calcium ion	-	IEA	-
GO:0051782	negative regulation of cell division	-	IDA	18541147
GO:0071228	cellular response to tumor cell	-	IDA	18541147

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	14632196
GO:0005758	mitochondrial intermembrane space	-	IEA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	IEA
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-622312	Inflammasomes	IEA
R-HSA-622312	Inflammasomes	TAS
R-HSA-844456	The NLRP3 inflammasome	IEA
R-HSA-844456	The NLRP3 inflammasome	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27470124	Associations of polymorphisms in TXNIP and gene-environment interactions with the risk of coronary artery disease in a Chinese Han population. (2016 Dec)	Wang XB	J Cell Mol Med
26643952	Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia. (2016 Feb 1)	Soriano-Tarraga C	Hum Mol Genet
29325019	Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation. (2018 Mar 15)	Zaghlool SB	Hum Mol Genet
23981442	Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)	McClintick JN	Alcohol