Gene: RGS14

10636
-
regulator of G protein signaling 14
protein-coding
5q35.3
Ensembl:ENSG00000169220 MIM:602513 Vega:OTTHUMG00000163324 UniprotKB:O43566
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
6.103e-1 (AD)  4.693e-1 (ND)   (Frontal_Cortex)
6.589e-1 (AD)  3.256e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASD20.845
LAMP50.843
NCDN0.839
CYP46A10.837
CAMKV0.832
ULK10.83
LRRC10B0.827
KCNIP20.827
HRH30.827
PWWP2B0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FZD10-0.46
OR4F5-0.442
TFPI2-0.436
IL18RAP-0.428
C9orf153-0.424
KCNJ15-0.423
KLRB1-0.422
IL2RG-0.416
CST7-0.415
TBX21-0.412

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RGS14 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RGS14 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of RGS14 mRNA21420995|2223033
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RGS14 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS14 mRNA16483693
D001280AtrazineAtrazine results in increased expression of RGS14 mRNA25929836
D001280AtrazineAtrazine results in increased expression of RGS14 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of RGS14 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of RGS14 mRNA18958704
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS14 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RGS14 mRNA28472532
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RGS14 mRNA27392435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS14 mRNA20938992
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RGS14 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RGS14 mRNA27392435
C544151jinfukangjinfukang results in increased expression of RGS14 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS14 mRNA23086925|2675264
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RGS14 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS14 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RGS14 mRNA23649840
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RGS14 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of RGS14 mRNA17426115
D011441PropylthiouracilPropylthiouracil results in increased expression of RGS14 mRNA24780913
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of RGS14 mRNA25172293
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RGS14 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of RGS14 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RGS14 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of RGS14 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RGS14 mRNA25979313
C088658zoledronic acidzoledronic acid results in increased expression of RGS14 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IEA-  
GO:0005092GDP-dissociation inhibitor activity-IDA15917656  
GO:0005096GTPase activator activity-IDA15917656  
GO:0005515protein binding-IPI21044950  21988832  
GO:0008017microtubule binding-IDA15917656  
GO:0019901protein kinase binding-IEA-  
GO:0030159receptor signaling complex scaffold activity-ISS-  
GO:0032794GTPase activating protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IEA-  
GO:0006913nucleocytoplasmic transport-ISS-  
GO:0006979response to oxidative stress-ISS-  
GO:0007051spindle organization-IMP15917656  
GO:0007059chromosome segregation-ISS-  
GO:0007612learning-ISS-  
GO:0007616long-term memory-ISS-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS9168931  
GO:0008542visual learning-ISS-  
GO:0010070zygote asymmetric cell division-ISS-  
GO:0031914negative regulation of synaptic plasticity-ISS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043407negative regulation of MAP kinase activity-ISS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043620regulation of DNA-templated transcription in response to stress-ISS-  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-ISS-  
GO:0048008platelet-derived growth factor receptor signaling pathway-ISS-  
GO:0050769positive regulation of neurogenesis-ISS-  
GO:0051301cell division-IMP17635935  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-ISS-  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005813centrosome-ISS-  
GO:0005819spindle-IDA15917656  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0016604nuclear body-ISS-  
GO:0016605PML body-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29577426Significant association between RGS14 rs12654812 and nephrolithiasis risk among Guangxi population in China. (2018 Mar 26)Long JJ Clin Lab Anal